Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Caroline C. Friedel"'
Autor:
Denise Ohnezeit, Jiabin Huang, Ute Westerkamp, Veronika Brinschwitz, Claudia Schmidt, Thomas Günther, Manja Czech-Sioli, Samira Weißelberg, Tabea Schlemeyer, Jacqueline Nakel, Julia Mai, Sabrina Schreiner, Carola Schneider, Caroline C Friedel, Hella Schwanke, Melanie M Brinkmann, Adam Grundhoff, Nicole Fischer
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012426 (2024)
Merkel cell polyomavirus (MCPyV) is the causative agent of the majority of Merkel cell carcinomas (MCC). The virus has limited coding capacity, with its early viral proteins, large T (LT) and small T (sT), being multifunctional and contributing to in
Externí odkaz:
https://doaj.org/article/d2f6de543c844e38b53096773b9b25a6
Autor:
Lara Djakovic, Thomas Hennig, Katharina Reinisch, Andrea Milić, Adam W. Whisnant, Katharina Wolf, Elena Weiß, Tobias Haas, Arnhild Grothey, Christopher S. Jürges, Michael Kluge, Elmar Wolf, Florian Erhard, Caroline C. Friedel, Lars Dölken
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Herpes simplex virus 1 (HSV-1) infection and stress responses disrupt transcription termination by RNA Polymerase II (Pol II). In HSV-1 infection, but not upon salt or heat stress, this is accompanied by a dramatic increase in chromatin acce
Externí odkaz:
https://doaj.org/article/88c94da7658643c8abd946d207f3dd82
Autor:
Manivel Lodha, Ihsan Muchsin, Christopher Jürges, Vanda Juranic Lisnic, Anne L'Hernault, Andrzej J Rutkowski, Bhupesh K Prusty, Arnhild Grothey, Andrea Milic, Thomas Hennig, Stipan Jonjic, Caroline C Friedel, Florian Erhard, Lars Dölken
Publikováno v:
PLoS Pathogens, Vol 19, Iss 5, p e1010992 (2023)
The genomes of both human cytomegalovirus (HCMV) and murine cytomegalovirus (MCMV) were first sequenced over 20 years ago. Similar to HCMV, the MCMV genome had initially been proposed to harbor ≈170 open reading frames (ORFs). More recently, omics
Externí odkaz:
https://doaj.org/article/ea5dbdd681fa4ad6a528c084c981f79a
Autor:
Yong Huang, Rut Tejero, Vivian K. Lee, Concetta Brusco, Theodore Hannah, Taylor B. Bertucci, Chrystian Junqueira Alves, Igor Katsyv, Michael Kluge, Ramsey Foty, Bin Zhang, Caroline C. Friedel, Guohao Dai, Hongyan Zou, Roland H. Friedel
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Huang et al demonstrate that glioblastoma cells upregulate axon guidance molecule Plexin-B2 to gain invasiveness and that Plexin-B2 promotes glioblastoma cell infiltration along axon fiber tracts in intracranial transplant models by modulating cellul
Externí odkaz:
https://doaj.org/article/a21043ef77f3429eb2a9321d811b140e
Autor:
Adam W. Whisnant, Christopher S. Jürges, Thomas Hennig, Emanuel Wyler, Bhupesh Prusty, Andrzej J. Rutkowski, Anne L’hernault, Lara Djakovic, Margarete Göbel, Kristina Döring, Jennifer Menegatti, Robin Antrobus, Nicholas J. Matheson, Florian W. H. Künzig, Guido Mastrobuoni, Chris Bielow, Stefan Kempa, Chunguang Liang, Thomas Dandekar, Ralf Zimmer, Markus Landthaler, Friedrich Grässer, Paul J. Lehner, Caroline C. Friedel, Florian Erhard, Lars Dölken
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Here, using computational integration of multi-omics data, the authors provide a detailed transcriptome and translatome of herpes simplex virus 1 (HSV-1), including previously unidentified ORFs and N-terminal extensions. The study also provides a HSV
Externí odkaz:
https://doaj.org/article/2bc69e036d254f1f89647997e0dbd0b2
Autor:
Xiuye Wang, Thomas Hennig, Adam W. Whisnant, Florian Erhard, Bhupesh K. Prusty, Caroline C. Friedel, Elmira Forouzmand, William Hu, Luke Erber, Yue Chen, Rozanne M. Sandri-Goldin, Lars Dölken, Yongsheng Shi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Herpes simplex virus-1 (HSV-1) infection disrupts transcription termination (DoTT) of host genes, but underlying mechanisms are unclear. Here, Wang et al. show that the HSV-1 immediate early protein ICP27 induces DoTT through interaction with the mRN
Externí odkaz:
https://doaj.org/article/86795a19df404ef6a9b5cb941f4f5451
Autor:
Marie-Sophie Friedl, Lara Djakovic, Michael Kluge, Thomas Hennig, Adam W. Whisnant, Simone Backes, Lars Dölken, Caroline C. Friedel
Publikováno v:
PLoS ONE, Vol 17, Iss 10 (2022)
The herpes simplex virus 1 (HSV-1) virion host shut-off (vhs) protein cleaves both cellular and viral mRNAs by a translation-initiation-dependent mechanism, which should spare circular RNAs (circRNAs). Here, we show that vhs-mediated degradation of l
Externí odkaz:
https://doaj.org/article/b3be6ae9e2074d9f965eef71a88bde10
Autor:
Philipp Metzger, Sabrina V. Kirchleitner, Michael Kluge, Lars M. Koenig, Christine Hörth, Carlotta A. Rambuscheck, Daniel Böhmer, Julia Ahlfeld, Sebastian Kobold, Caroline C. Friedel, Stefan Endres, Max Schnurr, Peter Duewell
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-16 (2019)
Abstract Background The tumor microenvironment (TME) combines features of regulatory cytokines and immune cell populations to evade the recognition by the immune system. Myeloid-derived suppressor cells (MDSC) comprise populations of immature myeloid
Externí odkaz:
https://doaj.org/article/7b1761a600b2421284a033f86cb2ba1f
Autor:
Rut Tejero, Yong Huang, Igor Katsyv, Michael Kluge, Jung-Yi Lin, Jessica Tome-Garcia, Nicolas Daviaud, Yuanshuo Wang, Bin Zhang, Nadejda M. Tsankova, Caroline C. Friedel, Hongyan Zou, Roland H. Friedel
Publikováno v:
EBioMedicine, Vol 42, Iss , Pp 252-269 (2019)
Background: Glioblastoma (GBM), a highly malignant brain tumor, invariably recurs after therapy. Quiescent GBM cells represent a potential source of tumor recurrence, but little is known about their molecular underpinnings. Methods: Patient-derived G
Externí odkaz:
https://doaj.org/article/738fbc64fbbe40599149dda3de204610
Autor:
Franziska Hufsky, Ana Abecasis, Patricia Agudelo-Romero, Magda Bletsa, Katherine Brown, Claudia Claus, Stefanie Deinhardt-Emmer, Li Deng, Caroline C. Friedel, María Inés Gismondi, Evangelia Georgia Kostaki, Denise Kühnert, Urmila Kulkarni-Kale, Karin J. Metzner, Irmtraud M. Meyer, Laura Miozzi, Luca Nishimura, Sofia Paraskevopoulou, Alba Pérez-Cataluña, Janina Rahlff, Emma Thomson, Charlotte Tumescheit, Lia van der Hoek, Lore Van Espen, Anne-Mieke Vandamme, Maryam Zaheri, Neta Zuckerman, Manja Marz
Publikováno v:
Viruses, Vol 14, Iss 7, p 1522 (2022)
Viruses are the cause of a considerable burden to human, animal and plant health, while on the other hand playing an important role in regulating entire ecosystems. The power of new sequencing technologies combined with new tools for processing “Bi
Externí odkaz:
https://doaj.org/article/0d63344a88c745c1b77f5879ac473c63