Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Caroline C Friedel"'
Autor:
Denise Ohnezeit, Jiabin Huang, Ute Westerkamp, Veronika Brinschwitz, Claudia Schmidt, Thomas Günther, Manja Czech-Sioli, Samira Weißelberg, Tabea Schlemeyer, Jacqueline Nakel, Julia Mai, Sabrina Schreiner, Carola Schneider, Caroline C Friedel, Hella Schwanke, Melanie M Brinkmann, Adam Grundhoff, Nicole Fischer
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012426 (2024)
Merkel cell polyomavirus (MCPyV) is the causative agent of the majority of Merkel cell carcinomas (MCC). The virus has limited coding capacity, with its early viral proteins, large T (LT) and small T (sT), being multifunctional and contributing to in
Externí odkaz:
https://doaj.org/article/d2f6de543c844e38b53096773b9b25a6
Autor:
Manivel Lodha, Ihsan Muchsin, Christopher Jürges, Vanda Juranic Lisnic, Anne L'Hernault, Andrzej J Rutkowski, Bhupesh K Prusty, Arnhild Grothey, Andrea Milic, Thomas Hennig, Stipan Jonjic, Caroline C Friedel, Florian Erhard, Lars Dölken
Publikováno v:
PLoS Pathogens, Vol 19, Iss 5, p e1010992 (2023)
The genomes of both human cytomegalovirus (HCMV) and murine cytomegalovirus (MCMV) were first sequenced over 20 years ago. Similar to HCMV, the MCMV genome had initially been proposed to harbor ≈170 open reading frames (ORFs). More recently, omics
Externí odkaz:
https://doaj.org/article/ea5dbdd681fa4ad6a528c084c981f79a
Autor:
Xiuye Wang, Liang Liu, Adam W Whisnant, Thomas Hennig, Lara Djakovic, Nabila Haque, Cindy Bach, Rozanne M Sandri-Goldin, Florian Erhard, Caroline C Friedel, Lars Dölken, Yongsheng Shi
Publikováno v:
PLoS Genetics, Vol 17, Iss 3, p e1009263 (2021)
Eukaryotic gene expression is extensively regulated by cellular stress and pathogen infections. We have previously shown that herpes simplex virus 1 (HSV-1) and several cellular stresses cause widespread disruption of transcription termination (DoTT)
Externí odkaz:
https://doaj.org/article/2e679acc20f04b73be31b6e85ae139cc
Autor:
Thomas Hennig, Marco Michalski, Andrzej J Rutkowski, Lara Djakovic, Adam W Whisnant, Marie-Sophie Friedl, Bhaskar Anand Jha, Marisa A P Baptista, Anne L'Hernault, Florian Erhard, Lars Dölken, Caroline C Friedel
Publikováno v:
PLoS Pathogens, Vol 14, Iss 3, p e1006954 (2018)
Lytic herpes simplex virus 1 (HSV-1) infection triggers disruption of transcription termination (DoTT) of most cellular genes, resulting in extensive intergenic transcription. Similarly, cellular stress responses lead to gene-specific transcription d
Externí odkaz:
https://doaj.org/article/0b734ce74d4b448b8f8c6a89158cb1cf
Autor:
Thomas Bonfert, Caroline C Friedel
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170914 (2017)
RNA-seq reads containing part of the poly(A) tail of transcripts (denoted as poly(A) reads) provide the most direct evidence for the position of poly(A) sites in the genome. However, due to reduced coverage of poly(A) tails by reads, poly(A) reads ar
Externí odkaz:
https://doaj.org/article/1e3e77e6e2f447bf839b5fe0cd789c9d
Autor:
Samantha J Griffiths, Manfred Koegl, Chris Boutell, Helen L Zenner, Colin M Crump, Francesca Pica, Orland Gonzalez, Caroline C Friedel, Gerald Barry, Kim Martin, Marie H Craigon, Rui Chen, Lakshmi N Kaza, Even Fossum, John K Fazakerley, Stacey Efstathiou, Antonio Volpi, Ralf Zimmer, Peter Ghazal, Jürgen Haas
Publikováno v:
PLoS Pathogens, Vol 9, Iss 8, p e1003514 (2013)
Herpes simplex virus type 1 (HSV-1) is a neurotropic virus causing vesicular oral or genital skin lesions, meningitis and other diseases particularly harmful in immunocompromised individuals. To comprehensively investigate the complex interaction bet
Externí odkaz:
https://doaj.org/article/c1319d0c08484c8a870675e878702559
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73071 (2013)
RNA sequencing (RNA-seq) provides novel opportunities for transcriptomic studies at nucleotide resolution, including transcriptomics of viruses or microbes infecting a cell. However, standard approaches for mapping the resulting sequencing reads gene
Externí odkaz:
https://doaj.org/article/0299a3e75fa44b7ba956df60d5c3f329
Autor:
Roland H Friedel, Caroline C Friedel, Thomas Bonfert, Ruijin Shi, Roland Rad, Philippe Soriano
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72338 (2013)
Somatic transposon mutagenesis in mice is an efficient strategy to investigate the genetic mechanisms of tumorigenesis. The identification of tumor driving transposon insertions traditionally requires the generation of large tumor cohorts to obtain i
Externí odkaz:
https://doaj.org/article/6881593e03b541daa34c1be6ebc960f5
Autor:
Lisa Marcinowski, Michael Lidschreiber, Lukas Windhager, Martina Rieder, Jens B Bosse, Bernd Rädle, Thomas Bonfert, Ildiko Györy, Miranda de Graaf, Olivia Prazeres da Costa, Philip Rosenstiel, Caroline C Friedel, Ralf Zimmer, Zsolt Ruzsics, Lars Dölken
Publikováno v:
PLoS Pathogens, Vol 8, Iss 9, p e1002908 (2012)
During viral infections cellular gene expression is subject to rapid alterations induced by both viral and antiviral mechanisms. In this study, we applied metabolic labeling of newly transcribed RNA with 4-thiouridine (4sU-tagging) to dissect the rea
Externí odkaz:
https://doaj.org/article/26bea85d59a24b618eaf3a8c6d163a79
Autor:
Milan Spasic, Caroline C Friedel, Johanna Schott, Jochen Kreth, Kathrin Leppek, Sarah Hofmann, Sevim Ozgur, Georg Stoecklin
Publikováno v:
PLoS Genetics, Vol 8, Iss 1, p e1002433 (2012)
In mammalian cells, AU-rich elements (AREs) are well known regulatory sequences located in the 3' untranslated region (UTR) of many short-lived mRNAs. AREs cause mRNAs to be degraded rapidly and thereby suppress gene expression at the posttranscripti
Externí odkaz:
https://doaj.org/article/f3a0f3b6987f401597aaa5b34e11b16e