Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Caroline C Duwaerts"'
Autor:
Andrew A Pierce, Caroline C Duwaerts, Kevin Siao, Aras N Mattis, Amanda Goodsell, Jody L Baron, Jacquelyn J Maher
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0183912 (2017)
Neutrophils and macrophages are important constituents of the hepatic inflammatory infiltrate in non-alcoholic steatohepatitis. These innate immune cells express CD18, an adhesion molecule that facilitates leukocyte activation. In the context of fatt
Externí odkaz:
https://doaj.org/article/946adfd66efe43ad835ac811cc2c088c
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79702 (2013)
Both Kupffer cells and invariant natural killer T (iNKT) cells suppress neutrophil-dependent liver injury in a mouse model of biliary obstruction. We hypothesize that these roles are interdependent and require iNKT cell-Kupffer cell cross-activation.
Externí odkaz:
https://doaj.org/article/4de84431c41c485eb6436acf4d1b5de1
Publikováno v:
Nutrients, Vol 14, Iss 19, p 4029 (2022)
STING, Tmem173, is involved in liver injury caused by both infectious and sterile inflammatory models. Its role in toxic liver injury and non-alcoholic fatty liver disease (NAFLD), however, is less clear. While a few groups have investigated its role
Externí odkaz:
https://doaj.org/article/ff478c1b319f4986a799cc6b5553f655
Autor:
Anas Alkhani, Cathrine Korsholm, Claire S. Levy, Sarah Mohamedaly, Caroline C. Duwaerts, Eric M. Pietras, Amar Nijagal
Publikováno v:
Journal of clinical medicine, vol 12, iss 1
Journal of Clinical Medicine; Volume 12; Issue 1; Pages: 337
Journal of Clinical Medicine; Volume 12; Issue 1; Pages: 337
Background: Biliary atresia (BA) is a progressive pediatric inflammatory disease of the liver that leads to cirrhosis and necessitates liver transplantation. The rapid progression from liver injury to liver failure in children with BA suggests that f
Autor:
Jacquelyn J. Maher, Aras N. Mattis, Ke Liu, Tao Su, Caitlin Peaslee, Sneha Rao, Cristina Esteva-Font, Julie B. Sneddon, Antonio Munoz-Howell, Zhe Liu, Caroline C. Duwaerts, Marisa W. Medina
Publikováno v:
Hepatology (Baltimore, Md.), vol 74, iss 4
Hepatology
Hepatology
BACKGROUND AND AIMS: Induced pluripotent stem cells (iPSCs) provide an important tool for the generation of patient-derived cells, including hepatocyte-like cells, by developmental cues through an endoderm intermediate. However, most iPSC lines fail
Autor:
Amy Yu, Carson Cable, Mahbubul H. Shihan, Sachin Sharma, Aras N. Mattis, Izolda Mileva, Yusuf A. Hannun, Caroline C. Duwaerts, Jennifer Y. Chen
1)ABSTRACTNonalcoholic fatty liver disease (NAFLD) is a common cause of liver disease worldwide, and is characterized by the accumulation of fat in the liver. Nonalcoholic steatohepatitis (NASH), an advanced form of NAFLD, is a leading cause of liver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdbfd5d708aacd6cfd766da13ee04d1f
https://doi.org/10.1101/2022.07.10.499388
https://doi.org/10.1101/2022.07.10.499388
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2022)
The endoplasmic reticulum is a central player in liver pathophysiology. Chronic injury to the ER through increased lipid content, alcohol metabolism, or accumulation of misfolded proteins causes ER stress, dysregulated hepatocyte function, inflammati
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 4, Pp 749-761 (2019)
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 4, Pp 749-761 (2019)
Macronutrient metabolism is a highly orchestrated process, with adipose tissue and liver each playing central roles in nutrient uptake, processing, transport, and storage. These 2 tissues form an important metabolic circuit, particularly as it relate
Autor:
Aras N. Mattis, Valerie M. Weaver, Lan Wei, Steve S. Ho, Yusuf A. Hannun, Lorena Pantano, Meghan S. Mooring, Bryan C. Fuchs, Jennifer Y. Chen, Alan C. Mullen, Regina Español-Suñer, Diego dos Santos Ferreira, Dean Yimlamai, Andrew M. Tager, Daniel Canals, Raymond T. Chung, Joe M. Segal, Vikram R. Rao, Amy Yu, Johanna R. Schaub, Mai Sedki, Caroline C. Duwaerts, Sarani Ghoshal, Hsiao-Yen Ma, Nadia M. E. Ayad, Scott M. Turner, Jimmy Kuang-Hsien Hu, Benjamin Newcomb, Megan M. Marlow, Stephanie A. Christenson, Izolda Mileva, Dean Sheppard, Sarah Alsamman
Publikováno v:
Sci Transl Med
Science translational medicine, vol 12, iss 557
Science translational medicine, vol 12, iss 557
Hepatic stellate cells (HSCs) drive hepatic fibrosis. Therapies that inactivate HSCs have clinical potential as antifibrotic agents. We previously identified acid ceramidase (aCDase) as an antifibrotic target. We showed that tricyclic antidepressants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a4b8c3ed8a9921917b7e90c8313188
https://europepmc.org/articles/PMC7976849/
https://europepmc.org/articles/PMC7976849/
Autor:
Russell K. Soon, Takao Iwawaki, Aras N. Mattis, Chris Her, Jacquelyn J. Maher, Kenji Kohno, Caroline C. Duwaerts, Kecvin Siao
Publikováno v:
Cell death and differentiation, vol 28, iss 5
X-box binding protein-1 (XBP1) is a transcription factor that plays a central role in controlling cellular responses to endoplasmic reticulum (ER) stress. Under stress conditions, the transcriptionally active form of XBP1 is generated by unique splic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f57a9dedc44fe26d0e3e6c50e6731616
https://doi.org/10.1101/2020.04.23.058446
https://doi.org/10.1101/2020.04.23.058446