Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Caroline C, Escoubas"'
Autor:
Yue Zhang, Anne Lanjuin, Suvagata Roy Chowdhury, Meeta Mistry, Carlos G Silva-García, Heather J Weir, Chia-Lin Lee, Caroline C Escoubas, Emina Tabakovic, William B Mair
Publikováno v:
eLife, Vol 8 (2019)
Target of rapamycin complex 1 (TORC1) and AMP-activated protein kinase (AMPK) antagonistically modulate metabolism and aging. However, how they coordinate to determine longevity and if they act via separable mechanisms is unclear. Here, we show that
Externí odkaz:
https://doaj.org/article/75f6972b9e4a42e6978e901cc13f3d20
Autor:
Jerika J. Barron, Nicholas M. Mroz, Sunrae E. Taloma, Madelene W. Dahlgren, Jorge Ortiz-Carpena, Leah C. Dorman, Ilia D. Vainchtein, Caroline C. Escoubas, Ari B. Molofsky, Anna V. Molofsky
Publikováno v:
bioRxiv
The innate immune system plays essential roles in brain synaptic development, and immune dysregulation is implicated in neurodevelopmental diseases. Here we show that a subset of innate lymphocytes (group 2 innate lymphoid cells, ILC2s) is required f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::466609c5840600ffa1fa935483ea97bc
https://doi.org/10.1101/2023.03.16.532850
https://doi.org/10.1101/2023.03.16.532850
Autor:
Leah C, Dorman, Phi T, Nguyen, Caroline C, Escoubas, Ilia D, Vainchtein, Yinghong, Xiao, Peter V, Lidsky, Haruna, Nakajo, Nicholas J, Silva, Christian, Lagares-Linares, Ellen Y, Wang, Sunrae E, Taloma, Beatriz, Cuevas, Hiromi, Nakao-Inoue, Brianna M, Rivera, Bjoern, Schwer, Carlo, Condello, Raul, Andino, Tomasz J, Nowakowski, Anna V, Molofsky
Publikováno v:
bioRxiv : the preprint server for biology.
Microglia, the innate immune cells of the brain, are exquisitely sensitive to dynamic changes in the neural environment. Using single cell RNA sequencing of the postnatal somatosensory cortex during topographic remapping, we identified a type I inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::77fff49b25e7b36499cbc1dc125ab87a
https://pubmed.ncbi.nlm.nih.gov/35233577
https://pubmed.ncbi.nlm.nih.gov/35233577
Autor:
Caroline C. Escoubas, Leah C. Dorman, Phi T. Nguyen, Christian Lagares-Linares, Haruna Nakajo, Sarah R. Anderson, Beatriz Cuevas, Ilia D. Vainchtein, Nicholas J. Silva, Yinghong Xiao, Peter V. Lidsky, Ellen Y. Wang, Sunrae E. Taloma, Hiromi Nakao-Inoue, Bjoern Schwer, Raul Andino, Tomasz J. Nowakowski, Anna V. Molofsky
SummaryMicroglia are brain resident phagocytes that can engulf synaptic components and extracellular matrix as well as whole neurons. However, whether there are unique molecular mechanisms that regulate these distinct phagocytic states is unknown. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32d4dfab35cc3d1bbd40ad782fcefd82
https://doi.org/10.1101/2021.04.29.441889
https://doi.org/10.1101/2021.04.29.441889
Autor:
Heather J. Weir, Caroline C. Escoubas, William B. Mair, Emina Tabakovic, Nicole M Clark, Laversenne
Loss of metabolic homeostasis is one of the hallmarks of the aging process that might contribute to pathogenesis by creating a permissive landscape over which neurodegenerative diseases can take hold. AMPK, a conserved energy sensor, extends lifespan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48534a60db11a9cbb5905861f506b13e
https://doi.org/10.1101/2020.11.05.370031
https://doi.org/10.1101/2020.11.05.370031
Autor:
William B. Mair, Thomas Koed Doktor, Brendan D. Manning, Carlos G. Silva-García, Anne Lanjuin, Sneha Dutta, Yue Zhang, Gitte Hoffmann Bruun, Brage S. Andresen, Heather J. Weir, Caroline Heintz, Ianessa Morantte, Gerta Hoxhaj, Caroline C. Escoubas
Publikováno v:
Nature
Heintz, C, Doktor, T K, Lanjuin, A, Escoubas, C C, Zhang, Y, Weir, H J, Dutta, S, Silva-García, C G, Bruun, G H, Morantte, I, Hoxhaj, G, Manning, B D, Andresen, B S & Mair, W B 2017, ' Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans ', Nature, vol. 541, no. 7635, pp. 102-106 . https://doi.org/10.1038/nature20789
Heintz, C, Doktor, T K, Lanjuin, A, Escoubas, C C, Zhang, Y, Weir, H J, Dutta, S, Silva-García, C G, Bruun, G H, Morantte, I, Hoxhaj, G, Manning, B D, Andresen, B S & Mair, W B 2017, ' Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans ', Nature, vol. 541, no. 7635, pp. 102-106 . https://doi.org/10.1038/nature20789
Ageing is driven by a loss of transcriptional and protein homeostasis and is the key risk factor for multiple chronic diseases. Interventions that attenuate or reverse systemic dysfunction associated with age therefore have the potential to reduce ov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f5ce8d0c08a62143cbe9656c588616
http://europepmc.org/articles/PMC5361225
http://europepmc.org/articles/PMC5361225
Autor:
Suvagata Roy Chowdhury, Heather J. Weir, Anne Lanjuin, Yue Zhang, William B. Mair, Carlos G. Silva-García, Meeta Mistry, Emina Tabakovic, Caroline C. Escoubas, Chia-Lin Lee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f237a539261003e967926ea9cf83d47b
https://doi.org/10.7554/elife.49158.046
https://doi.org/10.7554/elife.49158.046
Deregulation of CRTCs in Aging and Age-Related Disease Risk: (Trends in Genetics, 33, 303-321, 2017)
Publikováno v:
Trends in genetics : TIG. 34(4)
Advances in public health in the last century have seen a sharp increase in human life expectancy. With these changes have come increased incidence of age-related pathologies and health burdens in the elderly. Patient age is the biggest risk factor f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7198942f19f91e594f97a5d458372b10
https://pubmed.ncbi.nlm.nih.gov/28365140
https://pubmed.ncbi.nlm.nih.gov/28365140
Autor:
William B. Mair, Kristopher Burkewitz, Heather J. Weir, Renata L.S. Goncalves, Raymond Laboy, Caroline C. Escoubas, Pallas Yao, Matthew D. Hirschey, Frank K. Huynh
Mitochondrial network remodeling between fused and fragmented states facilitates mitophagy, interaction with other organelles, and metabolic flexibility. Aging is associated with a loss of mitochondrial network homeostasis, but cellular processes cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cfdf905d233e40200b2b9b93d943420
https://europepmc.org/articles/PMC5718936/
https://europepmc.org/articles/PMC5718936/
Autor:
Anne Lanjuin, William B. Mair, Brendan D. Manning, Caroline Heintz, Caroline C. Escoubas, Gitte Hoffmann Bruun, Gerta Hoxhaj, Carlos G. Silva-García, Thomas Koed Doktor, Yue Zhang, Ianessa Morantte, Sneha Dutta, Heather J. Weir, Brage S. Andresen
Publikováno v:
Heintz, C, Doktor, T K, Lanjuin, A, Escoubas, C C, Zhang, Y, Weir, H J, Dutta, S, Silva-García, C G, Bruun, G H, Morantte, I, Hoxhaj, G, Manning, B D, Andresen, B S & Mair, W B 2017, ' Correction: Corrigendum: Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans ', Nature, vol. 547, no. 7664, pp. 476 . https://doi.org/10.1038/nature23313
Nature 541, 102–106 (2017); doi:10.1038/nature20789 After publication, we noticed errors in the Source Data files for Fig. 2, Extended Data Figs 5, 6 and 9 and Supplementary Fig. 1 of this Letter. These result from data mislabelling, and have no ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83555e39adf9e3fe159274aae908d480
https://portal.findresearcher.sdu.dk/da/publications/8a46cdde-5f19-4538-b380-d05e637ea688
https://portal.findresearcher.sdu.dk/da/publications/8a46cdde-5f19-4538-b380-d05e637ea688