Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Caroline Brunetto de Farias"'
Autor:
Maria Eduarda Battistella, Natália Hogetop Freire, Bruno Toson, Matheus Dalmolin, Marcelo A. C. Fernandes, Isadora D. Tassinari, Mariane Jaeger, André T. Brunetto, Algemir L. Brunetto, Lauro Gregianin, Caroline Brunetto de Farias, Rafael Roesler
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 5, Pp 3990-4003 (2024)
Retinoic acid (RA) regulates stemness and differentiation in human embryonic stem cells (ESCs). Ewing sarcoma (ES) is a pediatric tumor that may arise from the abnormal development of ESCs. Here we show that RA impairs the viability of SK-ES-1 ES cel
Externí odkaz:
https://doaj.org/article/b0e933e8b0a2419ca47b31f833d979cc
Autor:
Rafael Pereira dos Santos, Bruna Almeida dos Santos, Lauro Gregianin, André Tessainer Brunetto, Algemir Lunardi Brunetto, Rafael Roesler, Caroline Brunetto de Farias
Publikováno v:
Revista Brasileira de Cancerologia, Vol 69, Iss 4 (2024)
Introduction: Ewing sarcoma (ES) is a highly aggressive type of childhood cancer characterized by a chromosomal translocation resulting in fusions between the gene encoding EWS RNA Binding Protein 1 (EWSR1) and one gene of the ETS family, most freque
Externí odkaz:
https://doaj.org/article/e6b58ab04e69436daf967e27e6e630cb
Autor:
Matheus Loureiro da Silva Cruz, Rafael Pereira dos Santos, Barbara Kunzler Souza, Mariane da Cunha Jaeger, Camila Alves da Silva, Lauro José Gregianin, Jiseh Fagundes Loss, Rebeca Ferreira Marques, Algemir Lunardi Brunetto, André Tesainer Brunetto, Rafael Roesler, Caroline Brunetto de Farias
Publikováno v:
Revista Brasileira de Cancerologia, Vol 69, Iss 3 (2023)
Introduction: Acute lymphocytic leukemia (ALL) is the most common cancer type in children and accounts for 80% of pediatric leukemias. Novel targets are necessary to improve survival rates for refractory and relapsed disease. There is accumulating ev
Externí odkaz:
https://doaj.org/article/09ba00fd63214fcdbaea678fe9b6ef79
Autor:
Barbara Kunzler Souza, Natalia Hogetop Freire, Thiago Santos Monteiro, Alice Laschuk Herlinger, Mariane Jaeger, Matheus G. S. Dalmolin, Caroline Brunetto de Farias, Lauro Gregianin, André T. Brunetto, Algemir L. Brunetto, Carol J. Thiele, Rafael Roesler
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 20, p 15242 (2023)
Changes in epigenetic programming have been proposed as being key events in the initiation and progression of childhood cancers. HMT euchromatic histone lysine methyltransferase 2 (G9a, EHMT2), which is encoded by the G9a (Ehmt2) gene, as well as its
Externí odkaz:
https://doaj.org/article/01066e73efb24012a3a2e46f5e70e212
Autor:
Rodrigo Rosa de Stefani, Elisa Cristina de Toni, Caroline Brunetto de Farias, André Tesainer Brunetto, Algemir Lunardi Brunetto, Rafael Roesler, Clarice Sampaio Alho, Deise Cristine Friedrich
Publikováno v:
Revista Brasileira de Cancerologia, Vol 68, Iss 2 (2022)
Introduction: The very aggressive soft tissue and bone pediatric tumor Ewing’s sarcoma (ES) is caused in most cases by the chromosomal translocation t(11;22)(q24;q12), which encodes an aberrant chimeric transcription factor (EWS-FLI1) that regulate
Externí odkaz:
https://doaj.org/article/f1e1be47124641eab63e9dbfdd85e364
Autor:
Clévia Rosset, Mariane da Cunha Jaeger, Eduardo Filippi-Chiela, Larissa Brussa Reis, Ivaine Taís Sauthier Sartor, Cristina Brinckmann Oliveira Netto, Caroline Brunetto de Farias, Rafael Roesler, Patricia Ashton-Prolla
Publikováno v:
Genetics and Molecular Biology, Vol 44, Iss 4 (2021)
Abstract Tuberous sclerosis complex (TSC) is an autosomal dominant cancer predisposition disorder caused by heterozygous mutations in TSC1 or TSC2 genes and characterized by mTORC1 hyperactivation. TSC-associated tumors develop after loss of heterozy
Externí odkaz:
https://doaj.org/article/fe7d672f066a416495abc777371618de
Autor:
Alexandre Perla, Lívia Fratini, Paula S. Cardoso, Carolina Nör, André T. Brunetto, Algemir L. Brunetto, Caroline Brunetto de Farias, Mariane Jaeger, Rafael Roesler
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Brain cancers are the leading cause of cancer-related deaths in children. Biological changes in these tumors likely include epigenetic deregulation during embryonal development of the nervous system. Histone acetylation is one of the most widely inve
Externí odkaz:
https://doaj.org/article/656536c4d17a43e08d31ac160e2405b5
Autor:
Barbara Kunzler Souza, Natalia Hogetop Freire, Mariane Jaeger, Caroline Brunetto de Farias, Algemir L. Brunetto, André T. Brunetto, Rafael Roesler
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 20, p 11292 (2021)
Epigenetic mechanisms, including post-translational modifications of DNA and histones that influence chromatin structure, regulate gene expression during normal development and are also involved in carcinogenesis and cancer progression. The histone m
Externí odkaz:
https://doaj.org/article/15d034e02f31461b95761f5c7abc2477
Autor:
Amanda Thomaz, Kelly de Vargas Pinheiro, Bárbara Kunzler Souza, Lauro Gregianin, Algemir L. Brunetto, André T. Brunetto, Caroline Brunetto de Farias, Mariane da Cunha Jaeger, Vijay Ramaswamy, Carolina Nör, Michael D. Taylor, Rafael Roesler
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Neurotrophins are critically involved in regulating normal neural development and plasticity. Brain-derived neurotrophic factor (BDNF), a neurotrophin that acts by binding to the tropomyosin receptor kinase B (TrkB) receptor, has also been implicated
Externí odkaz:
https://doaj.org/article/b5b0e0b16162448d9954f355f8f89f01
Autor:
Rafael Pereira, Dos Santos, Lauro, Gregianin, André, T Brunetto, Mariane, da Cunha Jaeger, Algemir, Lunardi Brunetto, Caroline, Brunetto de Farias, Rafael, Roesler
Publikováno v:
Current Stem Cell Research & Therapy. 18:926-936
Abstract: Resistance to chemotherapy poses a major challenge for cancer treatment. Reactivating a stem cell program resembling that seen in embryonic development can lead cancer cells to acquire a stem-cell phenotype characterized by expression of st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18146f761033315795837b37df1ea710
https://doi.org/10.2174/1574888x17666220627114710
https://doi.org/10.2174/1574888x17666220627114710