Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Caroline Broderick"'
Autor:
Scott W. Lowe, Direna Alonso-Curbelo, Zhenghao Chen, Mikala Egeblad, Ronald C. Hendrickson, Caroline Broderick, Xiang Li, Sha Tian, Alexandra Wuest, Wei Luan, Linda Fong, Georgia Schmitt, Nicholas Bernstein, Katharina Woess, Changyu Zhu, Ryan Smolkin, Jose M. Adrover, Riccardo Mezzadra, Yu-Jui Ho, Hsuan-An Chen
Supplementary Video S1 from Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::003e6f53d46ee1d4deb63fd0f6dd64d2
https://doi.org/10.1158/2159-8290.22542624.v1
https://doi.org/10.1158/2159-8290.22542624.v1
Autor:
Scott W. Lowe, Direna Alonso-Curbelo, Zhenghao Chen, Mikala Egeblad, Ronald C. Hendrickson, Caroline Broderick, Xiang Li, Sha Tian, Alexandra Wuest, Wei Luan, Linda Fong, Georgia Schmitt, Nicholas Bernstein, Katharina Woess, Changyu Zhu, Ryan Smolkin, Jose M. Adrover, Riccardo Mezzadra, Yu-Jui Ho, Hsuan-An Chen
Cellular senescence involves a stable cell-cycle arrest coupled to a secretory program that, in some instances, stimulates the immune clearance of senescent cells. Using an immune-competent liver cancer model in which senescence triggers CD8 T cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460aeb93387f41a0abbf2c6e4b2074ee
https://doi.org/10.1158/2159-8290.c.6549996
https://doi.org/10.1158/2159-8290.c.6549996
Autor:
Scott W. Lowe, Direna Alonso-Curbelo, Zhenghao Chen, Mikala Egeblad, Ronald C. Hendrickson, Caroline Broderick, Xiang Li, Sha Tian, Alexandra Wuest, Wei Luan, Linda Fong, Georgia Schmitt, Nicholas Bernstein, Katharina Woess, Changyu Zhu, Ryan Smolkin, Jose M. Adrover, Riccardo Mezzadra, Yu-Jui Ho, Hsuan-An Chen
Supplementary Video S2 from Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a7bf3e79e6fe6eeaf47cc654514deba
https://doi.org/10.1158/2159-8290.22542615.v1
https://doi.org/10.1158/2159-8290.22542615.v1
Autor:
Scott W. Lowe, Direna Alonso-Curbelo, Zhenghao Chen, Mikala Egeblad, Ronald C. Hendrickson, Caroline Broderick, Xiang Li, Sha Tian, Alexandra Wuest, Wei Luan, Linda Fong, Georgia Schmitt, Nicholas Bernstein, Katharina Woess, Changyu Zhu, Ryan Smolkin, Jose M. Adrover, Riccardo Mezzadra, Yu-Jui Ho, Hsuan-An Chen
Supplementary figures complement main figures to show that senescent cells have a rewired environmental signal sensing phenotype, exemplified by an enhanced IFN-g signaling, to facilitate anti-tumor immunity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435f5e0d82dac1219d8499eb8cf43722
https://doi.org/10.1158/2159-8290.22542636
https://doi.org/10.1158/2159-8290.22542636
Autor:
Scott W. Lowe, Direna Alonso-Curbelo, Zhenghao Chen, Mikala Egeblad, Ronald C. Hendrickson, Caroline Broderick, Xiang Li, Sha Tian, Alexandra Wuest, Wei Luan, Linda Fong, Georgia Schmitt, Nicholas Bernstein, Katharina Woess, Changyu Zhu, Ryan Smolkin, Jose M. Adrover, Riccardo Mezzadra, Yu-Jui Ho, Hsuan-An Chen
Low (50 pg/ml) and high (1 ng/ml) dose of IFN-γ treatment in proliferating and senescent NSP cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e234cdc12b05ad25cca33d3d8566c28
https://doi.org/10.1158/2159-8290.22542627.v1
https://doi.org/10.1158/2159-8290.22542627.v1
Autor:
Hsuan-An Chen, Yu-Jui Ho, Riccardo Mezzadra, Jose M. Adrover, Ryan Smolkin, Changyu Zhu, Katharina Woess, Nicholas Bernstein, Georgia Schmitt, Linda Fong, Wei Luan, Alexandra Wuest, Sha Tian, Xiang Li, Caroline Broderick, Ronald C. Hendrickson, Mikala Egeblad, Zhenghao Chen, Direna Alonso-Curbelo, Scott W. Lowe
Publikováno v:
Cancer discovery.
Cellular senescence involves a stable cell-cycle arrest coupled to a secretory program that, in some instances, stimulates the immune clearance of senescent cells. Using an immune-competent liver cancer model in which senescence triggers CD8 T cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081824cfe60ef0ad1b26ccf919b750ba
https://pubmed.ncbi.nlm.nih.gov/36302222
https://pubmed.ncbi.nlm.nih.gov/36302222
Autor:
Sung-Jin Lee, Teppei Yamaguchi, Haili Zhang, Hui Chen, Helene Baribault, Mehaben Patel, Jennifer Jean Brady, Jay Ye, Yang Li, Wen-Chen Yeh, Caroline Broderick, Zhengjian Zhang, Marni Nishimoto, Alberto Ponce
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
R-spondin (RSPO) proteins amplify Wnt signaling and stimulate regeneration in a variety of tissues. To repair tissue in a tissue-specific manner, tissue-targeted RSPO mimetic molecules are desired. Here, we mutated RSPO (RSPO2 F105R/F109A) to elimina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f13ebad43dc65494d6bfb8a45302809
https://doi.org/10.1038/s41598-020-70912-3
https://doi.org/10.1038/s41598-020-70912-3
Autor:
Leslie A. Lyons, Jacob A. Torres, Samantha L Kruger, Tselmeg Amarlkhagva, Caroline Broderick, Shagun Agrawal, Michal Mrug, Thomas Weimbs, John R. Dodam
Publikováno v:
Cell metabolism, vol 30, iss 6
Cell Metab
Cell Metab
Mild reduction in food intake was recently shown to slow polycystic kidney disease (PKD) progression in mouse models, but whether the effect was due to solely reduced calories or some other aspect of the diet has been unclear. We now show that the be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a878f785e5f9f68ad5dfb6e0f3b406
https://escholarship.org/uc/item/2nz6q4d9
https://escholarship.org/uc/item/2nz6q4d9
Autor:
Bernd Hoppe, Benjamin D. Cowley, Xiaofang Wang, Ross P. Holmes, Thomas Weimbs, Caroline Broderick, Saeed R. Khan, Vincenzo Savica, Vicente E. Torres, Michal Mrug, Mina Rezaei, Louis Lin, Jacob A. Torres
Publikováno v:
The Journal of clinical investigation. 129(10)
The rate of disease progression in autosomal-dominant polycystic kidney disease (ADPKD) has high intrafamilial variability, suggesting that environmental factors may play a role. We hypothesized that a prevalent form of renal insult may accelerate cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d8563a28f7f29cfe8fc908ffe8d6a8
https://pubmed.ncbi.nlm.nih.gov/31551591
https://pubmed.ncbi.nlm.nih.gov/31551591
Autor:
Zhengjianzhang Zhang, Caroline Broderick, Marni Shimoto, Teppei Yamaguchi, Sung-Jin Lee, Zhong Wang, Haili Zhang, Hui Chen, Jay Ye, Helene Baribault, Wen-Chen Yeh, Yang Li
Publikováno v:
Journal of Hepatology. 73:S243
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b93fe5f751c6a9a00fd83fbaeac63fa2
https://doi.org/10.1016/s0168-8278(20)30990-9
https://doi.org/10.1016/s0168-8278(20)30990-9