Selenium nanoparticles modulate histone methylation via lysine methyltransferase activity and S-adenosylhomocysteine depletion

Autor: Benoit Toubhans, Nour Alkafri, Marcos Quintela, David W. James, Caroline Bissardon, Salvatore Gazze, Franziska Knodel, Olivier Proux, Alexandra T. Gourlan, Philipp Rathert, Sylvain Bohic, Deyarina Gonzalez, Lewis W. Francis, Laurent Charlet, R. Steven Conlan

Publikováno v: Redox Biology, Vol 61, Iss , Pp 102641- (2023)

At physiological levels, the trace element selenium plays a key role in redox reactions through the incorporation of selenocysteine in antioxidant enzymes. Selenium has also been evaluated as a potential anti-cancer agent, where selenium nanoparticle

Externí odkaz: https://doaj.org/article/0d866209360b48c281dc8583dd5dbc1a

Biological Samples Preparation for Speciation at Cryogenic Temperature using High-Resolution X-Ray Absorption Spectroscopy

Autor: Sylvain Bohic, Olivier Proux, Eric Lahera, Mauro Rovezzi, Emmanuel Lesuisse, Marie-Pierre Isaure, Caroline Bissardon

Publikováno v: Journal of Visualized Experiments.

The study of elements with X-ray absorption spectroscopy (XAS) is of particular interest when studying the role of metals in biological systems. Sample preparation is a key and often complex procedure, particularly for biological samples. Although X-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834075bb83dcfc9392ddd58341df7d67
https://doi.org/10.3791/60849-v

An automated microfluidic platform integrating functional vascularized organoids-on-chip

Autor: Clément Quintard, Gustav Jonsson, Camille Laporte, Caroline Bissardon, Amandine Pitaval, Nicolas Werschler, Alexandra Leopoldi, Astrid Hagelkrüys, Pierre Blandin, Jean-Luc Achard, Fabrice Navarro, Yves Fouillet, Josef M. Penninger, Xavier Gidrol

The development of vascular networks on-chip is crucial for the long-term culture of three-dimensional cell aggregates such as organoids, spheroids, tumoroids, and tissue explants. Despite the rapid advancement of microvascular network systems and or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08e2a279f4b9e006eeaee93705db2b16
https://doi.org/10.1101/2021.12.29.474327

Selenium nanoparticles trigger alterations in ovarian cancer cell biomechanics

Autor: Lewis Francis, Laurent Charlet, R. Steven Conlan, Alexandra T. Gourlan, Benoit Toubhans, Deyarina Gonzalez, Sylvain Bohic, Salvatore A. Gazze, Caroline Bissardon

Publikováno v: Nanomedicine: Nanotechnology, Biology and Medicine
Nanomedicine: Nanotechnology, Biology and Medicine, 2020, 29, pp.102258. ⟨10.1016/j.nano.2020.102258⟩
Nanomedicine: Nanotechnology, Biology and Medicine, Elsevier, 2020, 29, pp.102258-. ⟨10.1016/j.nano.2020.102258⟩
'Nanomedicine: Nanotechnology, Biology and Medicine ', vol: 29, pages: 102258-1-102258-11 (2020)

International audience; High dose selenium acts as a cytotoxic agent, with potential applications in cancer treatment. However, clinical trials have failed to show any chemotherapeutic value of selenium at safe and tolerated doses (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1aee222148c5368dc55d3f0a381169a
https://hal.science/hal-03491574

Cell Culture on Silicon Nitride Membranes and Cryopreparation for Synchrotron X-ray Fluorescence Nano-analysis

Autor: Caroline, Bissardon, Solveig, Reymond, Murielle, Salomé, Lionel, André, Sam, Bayat, Peter, Cloetens, Sylvain, Bohic

Publikováno v: Journal of Visualized Experiments.

Very little is known about the distribution of metal ions at the subcellular level. However, those chemical elements have essential regulatory functions and their disturbed homeostasis is involved in various diseases. State-of-the-art synchrotron X-r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8cde0e7174588dd85e2030fbfa9e2f4
https://doi.org/10.3791/60461-v