Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Caroline Bennejean"'
Autor:
Pierre Renard, Philippe Chavatte, Christophe Mesangeau, Valérie Audinot, Basile Pérès, Philippe Delagrange, Saïd Yous, Daniel H. Caignard, Jean A. Boutin, Pascal Berthelot, Sophie Coumailleau, Caroline Bennejean, Descamps-Francois Carole
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:3426-3436
Novel heterodimer analogues of melatonin were synthesized, when agomelatine (1) and various aryl units are linked via a linear alkyl chain through the methoxy group. The compounds were tested for their actions at melatonin receptors. Several of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b748bf30437900a1a7b6edb83b2e9fe8
https://doi.org/10.1016/j.bmc.2010.04.008
https://doi.org/10.1016/j.bmc.2010.04.008
Autor:
Daniel Lesieur, Pierre Renard, Philippe Delagrange, Angéline Chanu, Sophie Coumailleau, Caroline Bennejean, Pascal Berthelot, Jean A. Boutin, Christophe Bochu, Saïd Yous, Sophie Durieux, Daniel H. Caignard, Valérie Audinot
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:2963-2974
Following our studies of the melatoninergic receptors, we have developed new tetrahydronaphthalenic derivatives of melatonin that have been tested as selective melatonin receptors ligands. Regarding the role of the phenyl substituent to obtain select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f1a362deb96013ac9c228b3ce80fd6b
https://doi.org/10.1016/j.bmc.2009.03.023
https://doi.org/10.1016/j.bmc.2009.03.023
Autor:
Daniel Lesieur, Basile Peres, Daniel Henri Caignard, Valérie Audinot, Caroline Bennejean, Jean A. Boutin, Philippe Delagrange, Pierre Renard, Saïd Yous, Mohamed Ettaoussi, Pascal Berthelot, Sophie Poissonnier-Durieux
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:8339-8348
A series of naphthalenic analogues of melatonin were prepared and evaluated as melatonin receptor MT(2) selective ligands. Activity and MT(2) selectivity can be modulated with suitable variations of the C-3 phenyl and the acyl group on the C-1 side c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::530373a7fb1652ecc2962878e1de4771
https://doi.org/10.1016/j.bmc.2008.08.052
https://doi.org/10.1016/j.bmc.2008.08.052
Autor:
Marie-Claude Viaud-Massuard, Valérie Audinot, Philippe Delagrange, Jean A. Boutin, Pierre Renard, Carlos Larraya, Caroline Bennejean, Jérôme Guillard
Publikováno v:
European Journal of Medicinal Chemistry. 39:515-526
Several 4-azaindole and 7-azaindole dimer analogues of melatonin with a bisalkoxyalkyl spacer between the position 5 of each heterocycle were synthetized. Our aim was to investigate the influence of the spacers length on the selectivity of such compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c89dba85246d27c68fa17d85ed5f35d
https://doi.org/10.1016/j.ejmech.2004.03.005
https://doi.org/10.1016/j.ejmech.2004.03.005
Autor:
Jean A. Boutin, Monique Mathe-Allainmat, Jean Andrieux, Jean Paul Nicolas, Caroline Bennejean, Cécile Pégurier, Philippe Delagrange, Laurence Morellato, Eminn Chahed, Michel Langlois
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:789-800
Amido derivatives 10-18 of the corresponding oxyamines were synthesised as melatoninergic ligands by the reaction of hydroxyphtalimide with the halogeno derivatives or the corresponding alcohols using Mitsunobu reaction conditions. The affinity of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b03f2152da03f16b5bcf49fd063136d3
https://doi.org/10.1016/s0968-0896(02)00328-0
https://doi.org/10.1016/s0968-0896(02)00328-0
Autor:
Caroline Bennejean, Hervé Poras, Alain Tomas, Marie-Claude Fournie-Zaluski, Pierre Renard, Françoise Beslot, Nicolas Inguimbert, Mohamed Selkti, Elizabeth Scalbert, Bernard-Pierre Roques, Franck Teffo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2001-2005
We have previously reported the design of a lead compound 1a for the joint inhibition of neprilysin (NEP, EC 3.4.24.11), angiotensin converting enzyme (ACE, EC 3.4.15.1) and endothelin converting enzyme (ECE-1, EC 3.4.24.71), three metallopeptidases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e60491eecf36cfd9a91a38e35f25edd
https://doi.org/10.1016/s0960-894x(02)00248-2
https://doi.org/10.1016/s0960-894x(02)00248-2
Autor:
Michele Boulanger, Jean A. Boutin, Patricia Pinson, Caroline Bennejean, Muriel Duflos, Pierre Renard, Guillaume Le Baut, Gaëtane Wielgosz-Collin
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry. 17:449-453
The synthesis and pharmacological evaluation of analogues of PD 160170, a neuropeptide Y1 (NPY) receptor antagonist are reported. Phamacomodulation of this 8-amino-5-nitro-6-phenylsulfonylquinoline was carried out by replacing the sulfone moiety by o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0099059f96f7d896152b2e17fb5784
https://doi.org/10.1080/1475636021000005758
https://doi.org/10.1080/1475636021000005758
Autor:
Philippe Chavatte, Valérie Audinot, Philippe Delagrange, N. Beaurain, G. Ferry, Jean A. Boutin, Caroline Bennejean, Saïd Yous, C. Mésangeau
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry. 17:409-414
Serotonin N-acetyltransferase (arylalkylamine N-acetyl-transferase, AANAT) is an enzyme that catalyses the first rate limiting step in the biosynthesis of melatonin (5-methoxy-N-acetyltryptamine). Different physiopathological disorders in human may b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2a4f313bc9f8559006dbaea30c6f585
https://doi.org/10.1080/1475636021000005721
https://doi.org/10.1080/1475636021000005721
5-Halobenzothiophene Analogues of Melatonin: Synthesis and Affinity for mt1 and MT2 Receptors in Man
Autor:
Caroline Bennejean, P. Depreux, Philippe Delagrange, V. Leclerc, D. Lesieur, J. Boutin, N. Beaurain
Publikováno v:
Pharmacy and Pharmacology Communications. 6:61-65
A novel series of melatonin analogues based on the benzothiophene nucleus is described. In these compounds the methoxy group was replaced by electron-attracting groups such halogens (Br and Cl) with the aim of supplementing structure-affinity relatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6132ffd3f1b846ebd4adf3ec25a557d
https://doi.org/10.1211/146080800128735647
https://doi.org/10.1211/146080800128735647
Autor:
G. Guillaumet, Ahmed Mamai, Beatrice Guardiola-Lemaitre, Caroline Bennejean, Pierre Renard, Philippe Delagrange, H. E. Howell, M.‐C. Viaud
Publikováno v:
Pharmacy and Pharmacology Communications. 5:199-206
A novel series of melatonin analogues based on the benzodioxin nucleus is described. The compounds were prepared in several steps from 2-carbethoxy-1,4-benzodioxin. Some of these derivatives competitively inhibited 2-[125I]-iodomelatonin binding to c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd2ee5514093c6d8533b4b4209272722
https://doi.org/10.1211/146080899128734604
https://doi.org/10.1211/146080899128734604