Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Caroline Baufeld"'
Autor:
Katharina Schregel, Caroline Baufeld, Miklos Palotai, Roberta Meroni, Paolo Fiorina, Jens Wuerfel, Ralph Sinkus, Yong-Zhi Zhang, Nathan McDannold, P. Jason White, Charles R. G. Guttmann
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Experimental autoimmune encephalomyelitis (EAE) is a model of multiple sclerosis (MS). EAE reflects important histopathological hallmarks, dissemination, and diversity of the disease, but has only moderate reproducibility of clinical and histopatholo
Externí odkaz:
https://doaj.org/article/e52b6047c031410ba4d4d21f01fbad7c
Treatment of Alzheimer’s disease by modulation of microglial neuroinflammation by nasal anti‐CD3 mAb
Autor:
Howard L Weiner, Juliana Lopes, Xiaoming Zhang, Caroline Baufeld, Rafael Rezende, Dennis J Selkoe, Oleg Butovsky
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f9f5cd63dae3482542c93bd9c93b01b
https://doi.org/10.1002/alz.068761
https://doi.org/10.1002/alz.068761
Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes
Autor:
Shabana M. Shaik, Hemraj B. Dodiya, Xiaoqiong Zhang, Jack A. Gilbert, Oleg Butovsky, Xulun Zhang, Neil Gottel, Thomas Kuntz, Jeffrey A. Leibowitz, Sangram S. Sisodia, Caroline Baufeld
Publikováno v:
The Journal of experimental medicine, vol 216, iss 7
The Journal of Experimental Medicine
The Journal of Experimental Medicine
An antibiotic cocktail leads to reductions in brain amyloidosis, altered morphology, and gene expression in microglia of male but not female transgenic mice that exhibit Aβ deposits. The microbiome plays a causal role in modulating Aβ burden and mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5734c69f7db2e95e3ce546f5a92cfd
https://doi.org/10.1084/jem.20182386
https://doi.org/10.1084/jem.20182386
Autor:
Luke M. Healy, Oleg Butovsky, John H. White, Sara Sedaghat, Jelani Clarke, Jack P. Antel, Naomi C. Futhey, Sergio E. Baranzini, Manon Blain, Moein Yaqubi, Caroline Baufeld
Vitamin D deficiency is a major environmental risk factor for the development of multiple sclerosis. The major circulating metabolite of vitamin D (25-hydroxyvitamin D) is converted to the active form (calcitriol) by the hydroxylase enzyme CYP27B1. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058832c4ea3ffa3a7edd2a9c0549c02e
https://doi.org/10.1101/2020.02.06.937482
https://doi.org/10.1101/2020.02.06.937482
Publikováno v:
J Neural Transm (Vienna)
Neuroinflammation is a hallmark of neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS). Microglia, the innate immune cells of the CNS, are the first to react to patholog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a44abb52d84c8df0f69ea9b2e648e1b
https://doi.org/10.1007/s00702-017-1795-7
https://doi.org/10.1007/s00702-017-1795-7
Autor:
Caroline Baufeld
Publikováno v:
Alzheimer's & Dementia. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ead808194e68a2743df1879d25fd2bb
https://doi.org/10.1016/j.jalz.2018.06.2966
https://doi.org/10.1016/j.jalz.2018.06.2966
Autor:
Ben A. Barres, Grace O. Robinson, Oleg Butovsky, David M. Holtzman, Kaoru Yamada, Courtney L. Sutphen, Kairuo Wang, Anne M. Fagan, John C. Morris, Adam L. Boxer, Gilbert Gallardo, Michael W. Wood, Lena McCue, Alzheimer's Disease Neuroimaging Initiative, Richard M. Tsai, Caroline Baufeld, Jorge L. Del-Aguila, William W. Seeley, Yang Shi, Hong Jiang, Scott T. Smith, Chengjie Xiong, Lea T. Grinberg, Wenjie Luo, Steven M. Paul, Carlos Cruchaga, Joseph Roh, Patrick Sullivan, Salvatore Spina, Bruce L. Miller, Lingzhi Zhao, Julio C. Rojas, Shane A. Liddelow, Mary Beth Finn
APOE4 is the strongest genetic risk factor for late-onset Alzheimer disease. ApoE4 increases brain amyloid-β pathology relative to other ApoE isoforms. However, whether APOE independently influences tau pathology, the other major proteinopathy of Al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::538a215200d08fd916888e38821a5bb7
https://europepmc.org/articles/PMC5641217/
https://europepmc.org/articles/PMC5641217/
Autor:
Asaf Madi, Elaine O’Loughlin, Anna Worthmann, Oleg Butovsky, Lien Beckers, Tsuneya Ikezu, Frank L. Heppner, Kristin Hartmann, Vladimir Litvak, Mar Gacias, Markus Glatzel, Zain Fanek, Zachary Humulock, Howard L. Weiner, Susanne Krasemann, Joerg Heeren, Jordi Ochando, Zhiping Weng, Ron Cialic, Christian Haass, Yang Xu, Narghes Calcagno, David M. Holtzman, Tobias Zrzavy, Bogdan Budnik, Cynthia A. Lemere, George Tweet, Hans Lassmann, Scott T. Smith, Hao Chen, Caroline Baufeld, Rachid El Fatimy, David J. Greco, Charlotte Madore, Fargol Mazaheri, Emily C. Tjon, Patricia Conde-Sanroman, Jason D. Ulrich
Publikováno v:
Immunity 47(3), 566-581.e9 (2017). doi:10.1016/j.immuni.2017.08.008
Microglia play a pivotal role in the maintenance of brain homeostasis but lose homeostatic function during neurodegenerative disorders. We identified a specific apolipoprotein E (APOE)-dependent molecular signature in microglia from models of amyotro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1c04d37b48c4a61a63dc78d139d1b0
https://pub.dzne.de/record/139513
https://pub.dzne.de/record/139513
Publikováno v:
Immunity. 48:842-843
TREM2 is known for its role in microglial phagocytosis and in neurodegenerative diseases. In this issue of Immunity, Filipello et al. (2018) show that microglial TREM2 is required for synaptic pruning in early development. TREM2-deficient mice show a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff2b9be742ab372699fe2f753fff5132
https://doi.org/10.1016/j.immuni.2018.04.034
https://doi.org/10.1016/j.immuni.2018.04.034
Autor:
Jack A. Gilbert, Xulun Zhang, Oleg Butovsky, Shabana M. Shaik, Hemraj B. Dodiya, Xiaoqiong Zhang, Thomas Kuntz, Neil Gottel, Caroline Baufeld, Jeffrey A. Leibowitz, Sangram S. Sisodia
Publikováno v:
Alzheimer's & Dementia. 15:P319-P319
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8644b552e47eeede6d35b4df00f295ea
https://doi.org/10.1016/j.jalz.2019.06.771
https://doi.org/10.1016/j.jalz.2019.06.771