Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Caroline B. Ho"'
Autor:
Denis Drygin, William G. Rice, David M. Ryckman, Daniel D. Von Hoff, John K. C. Lim, Sean E. O'Brien, Chris Proffitt, Kenna Anderes, Caroline B. Ho, Nicole Streiner, Nanni Huser, Mayuko Omori, Diwata Macalino, Joshua Bliesath, Adam Siddiqui-Jain
Drug combination therapies are commonly used for the treatment of cancers to increase therapeutic efficacy, reduce toxicity, and decrease the incidence of drug resistance. Although drug combination therapies were originally devised primarily by empir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::009230c7b846415ab8368b86d944ad43
https://doi.org/10.1158/1535-7163.c.6536134.v1
https://doi.org/10.1158/1535-7163.c.6536134.v1
Autor:
Denis Drygin, William G. Rice, David M. Ryckman, Daniel D. Von Hoff, John K. C. Lim, Sean E. O'Brien, Chris Proffitt, Kenna Anderes, Caroline B. Ho, Nicole Streiner, Nanni Huser, Mayuko Omori, Diwata Macalino, Joshua Bliesath, Adam Siddiqui-Jain
PDF file - 148K, The effects of CK2, MDC1 or XRCC1 depletion by siRNA on Gamma-H2AX levels induced by cisplatin or gemcitabine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fb6cb4e739d4f966916283f31a97e5
https://doi.org/10.1158/1535-7163.22499401.v1
https://doi.org/10.1158/1535-7163.22499401.v1
Autor:
Denis Drygin, William G. Rice, David M. Ryckman, Daniel D. Von Hoff, John K. C. Lim, Sean E. O'Brien, Chris Proffitt, Kenna Anderes, Caroline B. Ho, Nicole Streiner, Nanni Huser, Mayuko Omori, Diwata Macalino, Joshua Bliesath, Adam Siddiqui-Jain
PDF file - 63K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1724ae25a140fdf37ff1525f0a31ef0d
https://doi.org/10.1158/1535-7163.22499395
https://doi.org/10.1158/1535-7163.22499395
Autor:
Denis Drygin, William G. Rice, David M. Ryckman, Daniel D. Von Hoff, John K. C. Lim, Sean E. O'Brien, Chris Proffitt, Kenna Anderes, Caroline B. Ho, Nicole Streiner, Nanni Huser, Mayuko Omori, Diwata Macalino, Joshua Bliesath, Adam Siddiqui-Jain
PDF file - 97K, Quantified western blots for Gamma-H2AX and cleaved PARP levels normalized to �eta-actin levels from cisplatin or gemcitabine combinations with CX-4945.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e37083b780678c4a83fbc6e1748ed1
https://doi.org/10.1158/1535-7163.22499404.v1
https://doi.org/10.1158/1535-7163.22499404.v1
Autor:
Denis Drygin, William G. Rice, David M. Ryckman, Daniel D. Von Hoff, John K. C. Lim, Sean E. O'Brien, Chris Proffitt, Kenna Anderes, Caroline B. Ho, Nicole Streiner, Nanni Huser, Mayuko Omori, Diwata Macalino, Joshua Bliesath, Adam Siddiqui-Jain
PDF file - 1.0MB, The global role of CK2 in DNA repair and cancer therapies that potentially rely on CK2 mediated repair mechanisms.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d9190126d915dc4ca655ca09925838
https://doi.org/10.1158/1535-7163.22499398
https://doi.org/10.1158/1535-7163.22499398
Autor:
William G. Rice, Kenna Anderes, Daniel Von Hoff, John K. C. Lim, Jeffrey P. Whitten, Katy Trent, Chris Proffitt, Caroline B. Ho, Josh Bliesath, Amy Lin, Michael Schwaebe, Sean O'Brien, Adam Siddiqui-Jain, Denis Drygin
Supplementary Methods and Materials from Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7507050d577b19fc474daaa9d68bdaef
https://doi.org/10.1158/0008-5472.22378134
https://doi.org/10.1158/0008-5472.22378134
Autor:
William G. Rice, Kenna Anderes, David Ryckman, Ross D. Hannan, Megan J. Bywater, Elaine Sanij, Jaclyn E. Quin, Nicole Streiner, Adam Siddiqui-Jain, Michael K. Schwaebe, Mustapha Haddach, Mayuko Omori, Chris Proffitt, Sean E. O'Brien, Caroline B. Ho, Josh Bliesath, Amy Lin, Denis Drygin
Supplementary Materials from Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0b64b9899bae18205e730a978712b0
https://doi.org/10.1158/0008-5472.22387916.v1
https://doi.org/10.1158/0008-5472.22387916.v1
Autor:
Chris Proffitt, Johnny Y. Nagasawa, Levan Darjania, Eric Stefan, Ryan Stansfield, Sean O'Brien, Nicole Streiner, Jeffrey P. Whitten, Joshua R. Bliesath, Peter C. Chua, Caroline B. Ho, Pauline Bourbon, William G. Rice, Fabrice Pierre, Adam Siddiqui-Jain, Ta Kung Chen, Kenna Anderes, Anne Vialettes, Mustapha Haddach, David M. Ryckman, Michael K. Schwaebe, Denis Drygin, Jerome Michaux, May Omori
Publikováno v:
Molecular and Cellular Biochemistry. 356:37-43
In this article we describe the preclinical characterization of 5-(3-chlorophenylamino) benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first orally available small molecule inhibitor of protein CK2 in clinical trials for cancer. CX-4945
Autor:
Caroline B. Ho, Daniel D. Von Hoff, Denis Drygin, Chris Proffitt, Jeffrey P. Whitten, Kenna Anderes, William G. Rice, Josh Bliesath, Amy M. Lin, John K.C. Lim, Katy Trent, Sean O'Brien, Michael K. Schwaebe, Adam Siddiqui-Jain
Publikováno v:
Cancer Research. 69:7653-7661
Hallmark deregulated signaling in cancer cells drives excessive ribosome biogenesis within the nucleolus, which elicits unbridled cell growth and proliferation. The rate-limiting step of ribosome biogenesis is synthesis of rRNA (building blocks of ri
Autor:
William G. Rice, Joshua R. Bliesath, Adam Siddiqui-Jain, Kenna Anderes, Diwata Macalino, Chris Proffitt, Denis Drygin, John K.C. Lim, David M. Ryckman, Nicole Streiner, Caroline B. Ho, Daniel D. Von Hoff, Sean O'Brien, Mayuko Omori, Nanni Huser
Publikováno v:
Molecular cancer therapeutics. 11(4)
Drug combination therapies are commonly used for the treatment of cancers to increase therapeutic efficacy, reduce toxicity, and decrease the incidence of drug resistance. Although drug combination therapies were originally devised primarily by empir