Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans

Autor: A. Augusto Peluso, Agnete T. Lundgaard, Parizad Babaei, Felippe Mousovich-Neto, Andréa L. Rocha, Mads V. Damgaard, Emilie G. Bak, Thiyagarajan Gnanasekaran, Ole L. Dollerup, Samuel A. J. Trammell, Thomas S. Nielsen, Timo Kern, Caroline B. Abild, Karolina Sulek, Tao Ma, Zach Gerhart-Hines, Matthew P. Gillum, Manimozhiyan Arumugam, Cathrine Ørskov, Douglas McCloskey, Niels Jessen, Markus J. Herrgård, Marcelo A. S. Mori, Jonas T. Treebak

Publikováno v: Peluso, A A, Lundgaard, A T, Babaei, P, Mousovich-Neto, F, Rocha, A L, Damgaard, M V, Bak, E G, Gnanasekaran, T, Dollerup, O L, Trammell, S A J, Nielsen, T S, Kern, T, Abild, C B, Sulek, K, Ma, T, Gerhart-Hines, Z, Gillum, M P, Arumugam, M, Ørskov, C, McCloskey, D, Jessen, N, Herrgård, M J, Mori, M A S & Treebak, J T 2023, ' Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans ', npj aging, vol. 9, 7 . https://doi.org/10.1038/s41514-023-00106-4
Peluso, A A, Lundgaard, A T, Babaei, P, Mousovich-Neto, F, Rocha, A L, Damgaard, M V, Bak, E G, Gnanasekaran, T, Dollerup, O L, Trammell, S A J, Nielsen, T S, Kern, T, Abild, C B, Sulek, K, Ma, T, Gerhart-Hines, Z, Gillum, M P, Arumugam, M, Ørskov, C, McCloskey, D, Jessen, N, Herrgård, M J, Mori, M A S & Treebak, J T 2023, ' Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans ', npj aging, vol. 9, no. 1, pp. 1-21 . https://doi.org/10.1038/s41514-023-00106-4

The gut microbiota impacts systemic levels of multiple metabolites including NAD+ precursors through diverse pathways. Nicotinamide riboside (NR) is an NAD+ precursor capable of regulating mammalian cellular metabolism. Some bacterial families expres

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https://doi.org/10.1038/s41514-023-00106-4