Radiological, pathological and surgical outcomes after neoadjuvant endocrine treatment in patients with ER-positive/HER2-negative breast cancer with a clinical high risk and a low-risk 70-gene signature

Autor: Josefien P. van Olmen, Chaja F. Jacobs, Sanne A.L. Bartels, Claudette E. Loo, Joyce Sanders, Marie-Jeanne T.F.D. Vrancken Peeters, Caroline A. Drukker, Frederieke H. van Duijnhoven, Marleen Kok

Publikováno v: Breast, Vol 75, Iss , Pp 103726- (2024)

Objective: This study aims to evaluate the response to and surgical benefits of neoadjuvant endocrine therapy (NET) in ER+/HER2-breast cancer patients who are clinically high risk, but genomic low risk according to the 70-gene signature (MammaPrint).

Externí odkaz: https://doaj.org/article/704ad2649c1245a2bc5b540ca828061f

Obesity-associated changes in molecular biology of primary breast cancer

Autor: Ha-Linh Nguyen, Tatjana Geukens, Marion Maetens, Samuel Aparicio, Ayse Bassez, Ake Borg, Jane Brock, Annegien Broeks, Carlos Caldas, Fatima Cardoso, Maxim De Schepper, Mauro Delorenzi, Caroline A. Drukker, Annuska M. Glas, Andrew R. Green, Edoardo Isnaldi, Jórunn Eyfjörð, Hazem Khout, Stian Knappskog, Savitri Krishnamurthy, Sunil R. Lakhani, Anita Langerod, John W. M. Martens, Amy E. McCart Reed, Leigh Murphy, Stefan Naulaerts, Serena Nik-Zainal, Ines Nevelsteen, Patrick Neven, Martine Piccart, Coralie Poncet, Kevin Punie, Colin Purdie, Emad A. Rakha, Andrea Richardson, Emiel Rutgers, Anne Vincent-Salomon, Peter T. Simpson, Marjanka K. Schmidt, Christos Sotiriou, Paul N. Span, Kiat Tee Benita Tan, Alastair Thompson, Stefania Tommasi, Karen Van Baelen, Marc Van de Vijver, Steven Van Laere, Laura van’t Veer, Giuseppe Viale, Alain Viari, Hanne Vos, Anke T. Witteveen, Hans Wildiers, Giuseppe Floris, Abhishek D. Garg, Ann Smeets, Diether Lambrechts, Elia Biganzoli, François Richard, Christine Desmedt

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Abstract Obesity is associated with an increased risk of developing breast cancer (BC) and worse prognosis in BC patients, yet its impact on BC biology remains understudied in humans. This study investigates how the biology of untreated primary BC di

Externí odkaz: https://doaj.org/article/449fce543ad84736bc9d60953aa2df60

Ten-year follow-up of the observational RASTER study, prospective evaluation of the 70-gene signature in ER-positive, HER2-negative, node-negative, early breast cancer

Autor: Sonja B. Vliek, Florentine S. Hilbers, Agnes Jager, Valesca P. Retèl, Jolien M. Bueno de Mesquita, Caroline A. Drukker, Sanne C. Veltkamp, Anneke M. Zeillemaker, Emiel J. Rutgers, Harm van Tinteren, Wim H. van Harten, Laura J. van 't Veer, Marc J. van de Vijver, Sabine C. Linn

Publikováno v: European Journal of Cancer, 175, 169-179. Elsevier Limited
European Journal of Cancer, 175, 169-179. Elsevier Ltd.
European journal of cancer, 175, 169-179. Elsevier

Introduction: Prognostic gene expression signatures can be used in combination with classical clinicopathological factors to guide adjuvant chemotherapy decisions in ER-positive, HER2-negative breast cancer. However, long-term outcome data after intr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7edd507887970d9814de1ccbf3990d
http://www.scopus.com/inward/record.url?scp=85138040656&partnerID=8YFLogxK

Agreement on risk assessment and chemotherapy recommendations among breast cancer specialists: a survey within the MINDACT cohort

Autor: Josephine M.N. Lopes Cardozo, Sherylene E. Veira, Laila Ait Hassou, Aimé Lambert Uwimana, Ivana Božović-Spasojević, Jan Bogaerts, Fatima Cardoso, Marjanka K. Schmidt, Emiel J.T. Rutgers, Coralie Poncet, Caroline A. Drukker

Publikováno v: European Journal of Cancer. 175:S64

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d7d7f449d680917145b1b1280253597
https://doi.org/10.1016/s0959-8049(22)01521-0