Zobrazeno 1 - 10
of 235
pro vyhledávání: '"Caroline A Heckman"'
Autor:
Alina Malyutina, Muntasir Mamun Majumder, Wenyu Wang, Alberto Pessia, Caroline A Heckman, Jing Tang
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 5, p e1006752 (2019)
High-throughput drug screening has facilitated the discovery of drug combinations in cancer. Many existing studies adopted a full matrix design, aiming for the characterization of drug pair effects for cancer cells. However, the full matrix design ma
Externí odkaz:
https://doaj.org/article/2b9f6fde87584ef2879092c13f3dddf6
Autor:
Matilda Roos-Mattila, Pauliina Kallio, Tamara J. Luck, Minttu Polso, Romika Kumari, Piia Mikkonen, Katja Välimäki, Minna Malmstedt, Pekka Ellonen, Teijo Pellinen, Caroline A. Heckman, Harri Mustonen, Pauli A. Puolakkainen, Kari Alitalo, Olli Kallioniemi, Tuomas Mirtti, Antti S. Rannikko, Vilja M. Pietiäinen, Hanna E. Seppänen
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-18 (2024)
Abstract Clear-cell renal cell carcinoma (ccRCC) is the most common origin of pancreatic metastases (PM). Distinct genomic aberrations, favorable prognosis, and clinical observations on high angiogenesis, and succeeding tyrosine kinase inhibitor (TKI
Externí odkaz:
https://doaj.org/article/78e3d2037cf943b789d38da6adb44f0e
Autor:
Mahesh Tambe, Sarah Unterberger, Mette C. Kriegbaum, Ida Vänttinen, Ezgi June Olgac, Markus Vähä-Koskela, Mika Kontro, Krister Wennerberg, Caroline A. Heckman
Publikováno v:
Cell Death and Disease, Vol 15, Iss 10, Pp 1-9 (2024)
Abstract Venetoclax plus azacitidine treatment is clinically beneficial for elderly and unfit acute myeloid leukemia (AML) patients. However, the treatment is rarely curative, and relapse due to resistant disease eventually emerges. Since no current
Externí odkaz:
https://doaj.org/article/763798c230da4af69fc6e0e76963425d
Autor:
Aleksandr Ianevski, Kristen Nader, Kyriaki Driva, Wojciech Senkowski, Daria Bulanova, Lidia Moyano-Galceran, Tanja Ruokoranta, Heikki Kuusanmäki, Nemo Ikonen, Philipp Sergeev, Markus Vähä-Koskela, Anil K. Giri, Anna Vähärautio, Mika Kontro, Kimmo Porkka, Esa Pitkänen, Caroline A. Heckman, Krister Wennerberg, Tero Aittokallio
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Intratumoral cellular heterogeneity necessitates multi-targeting therapies for improved clinical benefits in advanced malignancies. However, systematic identification of patient-specific treatments that selectively co-inhibit cancerous cell
Externí odkaz:
https://doaj.org/article/ec1c01797011424aba8a717abe6ee43c
Autor:
Mehdi Mirzaie, Elham Gholizadeh, Juho J. Miettinen, Filipp Ianevski, Tanja Ruokoranta, Jani Saarela, Mikko Manninen, Susanna Miettinen, Caroline A. Heckman, Mohieddin Jafari
Publikováno v:
Oncogenesis, Vol 13, Iss 1, Pp 1-12 (2024)
Abstract Acute myeloid leukemia (AML), a heterogeneous and aggressive blood cancer, does not respond well to single-drug therapy. A combination of drugs is required to effectively treat this disease. Computational models are critical for combination
Externí odkaz:
https://doaj.org/article/f5b0fe31430c416baa152c430c9d0f41
Autor:
Marja Hakkarainen, Jessica R. Koski, Caroline A. Heckman, Pekka Anttila, Raija Silvennoinen, Juha Lievonen, Outi Kilpivaara, Ulla Wartiovaara‐Kautto
Publikováno v:
eJHaem, Vol 3, Iss 4, Pp 1352-1357 (2022)
Abstract Observations of inherited susceptibility to multiple myeloma have led to active research in defining predisposing genes to the disease. Here, we analysed 128 plasma cell dyscrasia patients’ germline whole‐exome sequencing data. Rare domi
Externí odkaz:
https://doaj.org/article/2c12cac227bf47e280d6d74f3b53ad94
Autor:
Heikki Kuusanmäki, Sari Kytölä, Ida Vänttinen, Tanja Ruokoranta, Amanda Ranta, Jani Huuhtanen, Minna Suvela, Alun Parsons, Annasofia Holopainen, Anu Partanen, Milla E.L. Kuusisto, Sirpa Koskela, Riikka Räty, Maija Itälä-Remes, Imre Västrik, Olli Dufva, Sanna Siitonen, Kimmo Porkka, Krister Wennerberg, Caroline A. Heckman, Pia Ettala, Marja Pyörälä, Johanna Rimpiläinen, Timo Siitonen, Mika Kontro
Publikováno v:
Haematologica, Vol 108, Iss 7 (2022)
The BCL-2 inhibitor venetoclax has revolutionized the treatment of acute myeloid leukemia (AML) in patients not benefiting from intensive chemotherapy. Nevertheless, treatment failure remains a challenge, and predictive markers are needed, particular
Externí odkaz:
https://doaj.org/article/ed146fcdf2474b39baf1bf345a6c2b2c
Autor:
Ken Flanagan, Romika Kumari, Juho J. Miettinen, Staci L. Haney, Michelle L. Varney, Jacob T. Williams, Muntasir M. Majumder, Minna Suvela, Ana Slipicevic, Fredrik Lehmann, Nina N. Nupponen, Sarah A. Holstein, Caroline A. Heckman
Publikováno v:
HemaSphere, Vol 6, Iss 3, p e687 (2022)
Immunoglobulin light-chain (AL) amyloidosis is a rare disease caused by clonal plasma cell secretion of misfolded light chains that assemble as toxic amyloid fibrils, depositing in vital organs including the heart and kidneys, causing organ dysfuncti
Externí odkaz:
https://doaj.org/article/9b8d9fd8a74e40a7942a0ec1bf52d4d7
Publikováno v:
EBioMedicine, Vol 50, Iss , Pp 67-80 (2019)
Background: Probing genetic dependencies of cancer cells can improve our understanding of tumour development and progression, as well as identify potential drug targets. CRISPR-Cas9-based and shRNA-based genetic screening are commonly utilized to ide
Externí odkaz:
https://doaj.org/article/cda13cc53f064771be1c84b303f26f63
Autor:
Paul Kerbs, Sebastian Vosberg, Stefan Krebs, Alexander Graf, Helmut Blum, Anja Swoboda, Aarif M. N. Batcha, Ulrich Mansmann, Dirk Metzler, Caroline A. Heckman, Tobias Herold, Philipp A. Greif
Publikováno v:
Haematologica, Vol 107, Iss 1 (2021)
Identification of fusion genes in clinical routine is mostly based on cytogenetics and targeted molecular genetics, such as metaphase karyotyping, fluorescence in situ hybridization and reverse-transcriptase polymerase chain reaction. However, sequen
Externí odkaz:
https://doaj.org/article/7c980547d3e4461f832d126db8b1c6dc