Looking back to look forward: Surviving COVID-19 and the future of the NHS

Autor: Adam Vacek, Siddharthan Chandran, Linda Bauld, Carey Lunan, Andrew Horne, Steve Kerr, Caroline Whitworth, Wojcik Wojtek

Publikováno v: Vacek, A, Chandran, S, Bauld, L, Lunan, C, Horne, A W, Kerr, S, Whitworth, C & Wojcik, W 2023, ' Looking back to look forward : Surviving COVID-19 and the future of the NHS ', Journal of the Royal College of Physicians of Edinburgh . https://doi.org/10.1177/14782715231173667

The COVID-19 pandemic affected healthcare systems worldwide, including the National Health Service (NHS). It drastically changed the practice and delivery of healthcare and laid bare longstanding structural flaws. It also brought a time of innovation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a9c6b9b6fb58d7eb938ca6cce9c9576
https://doi.org/10.1177/14782715231173667

Malignant hypertension

Autor: Caroline Whitworth, Stewart Fleming

Malignant hypertension (MH) is recognized clinically by elevated blood pressure together with retinal haemorrhages or exudates with or without papilloedema (grades III or IV hypertensive retinopathy); and may constitute a hypertensive emergency or cr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8f614cfce7a074f8fbc4e106cbb960f
https://doi.org/10.1093/med/9780199592548.003.0216

4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors

Autor: Jeremy John Payne, Geoff W. Mellor, Smith Kathryn Jane, Richard A. Williamson, Sebastien Andre Campos, Geoffrey J. Cutler, Caroline Whitworth, Mary A. Morse, Michael David Barker, Heather Hobbs, Rick P. C. Cousins, Duncan S. Holmes, Daniel Terence Tape, Paul Bamborough, John Martin Pritchard, John Liddle, Chris Ioannou

Publikováno v: Bioorganicmedicinal chemistry letters. 19(9)

The synthesis and SAR of a novel series of IKK2 inhibitors are described. Modification around the hinge binding region of the 7-azaindole led to a series of potent and selective inhibitors with good cellular activity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac9d3089c47e68ac4f0cac67941fe59
https://pubmed.ncbi.nlm.nih.gov/19349179

Design and synthesis of orally active pyrrolidin-2-one-based factor Xa inhibitors

Autor: Vipulkumar Kantibhai Patel, Máire A. Convery, J. Nicole Hamblin, Andrew M. Mason, Andrew R. Leach, N. Paul King, Shah Gita Punjabhai, Stefan Senger, Laiq Chaudry, Caroline Whitworth, Rebecca Fenwick, Robert J. Young, Matthew Campbell, Cynthia L. Kurtis, Claudine Haslam, Henry Anderson Kelly, Champa Patel, Weston Helen Elisabeth, Charlotte Jane Mitchell, David W. Brown, Gary R. Manchee, Nigel S. Watson, Chuen Chan

Publikováno v: Bioorganicmedicinal chemistry letters. 16(14)

A series of novel, non-basic 3-(6-chloronaphth-2-ylsulfonyl)aminopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating an alanylamide P4 group, was designed and synthesised. Within this series, the N-2-(morpholin-4-yl)-2-oxoethyl derivativ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e4aa8609923e3b93ebe2c35a44f9bf
https://pubmed.ncbi.nlm.nih.gov/16697194

Health and Social Conditions of Street Children in Honduras

Autor: Martha Caroline Whitworth Wittig, James D. Wright, Donald C. Kaminsky

Publikováno v: Archives of Pediatrics & Adolescent Medicine. 147:279

The United Nations' Year of the Child and its Declaration on the Rights of Children have focused the attention of the pediatric community on the situation of homeless street children in less developed countries throughout the world. Recent investigat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a802154268caa533fe024bd370c850
https://doi.org/10.1001/archpedi.1993.02160270041015