Bacteroidota inhibit microglia clearance of amyloid-beta and promote plaque deposition in Alzheimer’s disease mouse models

Autor: Caroline Wasén, Leah C. Beauchamp, Julia Vincentini, Shuqi Li, Danielle S. LeServe, Christian Gauthier, Juliana R. Lopes, Thais G. Moreira, Millicent N. Ekwudo, Zhuoran Yin, Patrick da Silva, Rajesh K. Krishnan, Oleg Butovsky, Laura M. Cox, Howard L. Weiner

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Abstract The gut microbiota and microglia play critical roles in Alzheimer’s disease (AD), and elevated Bacteroides is correlated with cerebrospinal fluid amyloid-β (Aβ) and tau levels in AD. We hypothesize that Bacteroides contributes to AD by m

Externí odkaz: https://doaj.org/article/5a13ffd6448641528a8fa807f7ea2f20

Cohesin-Mediated Chromatin Interactions and Autoimmunity

Autor: Venkataragavan Chandrasekaran, Nina Oparina, Maria-Jose Garcia-Bonete, Caroline Wasén, Malin C. Erlandsson, Eric Malmhäll-Bah, Karin M. E. Andersson, Maja Jensen, Sofia T. Silfverswärd, Gergely Katona, Maria I. Bokarewa

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Proper physiological functioning of any cell type requires ordered chromatin organization. In this context, cohesin complex performs important functions preventing premature separation of sister chromatids after DNA replication. In partnership with C

Externí odkaz: https://doaj.org/article/1022e5b4095b48e990308bb6466e0acc

Nicotine Changes the microRNA Profile to Regulate the FOXO Memory Program of CD8+ T Cells in Rheumatoid Arthritis

Autor: Caroline Wasén, Caroline Ospelt, Alessandro Camponeschi, Malin C. Erlandsson, Karin M. E. Andersson, Sofia Töyrä Silfverswärd, Steffen Gay, Maria I. Bokarewa

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Objective: Smoking suppresses PD-1 expression in patients with rheumatoid arthritis (RA). In this study, we assess if smoking changed the epigenetic control over CD8+ T cell memory formation through a microRNA (miR) dependent mechanism.Methods: Pheno

Externí odkaz: https://doaj.org/article/94d6b351ce38470a962b6ef898ad58c8

Smoking Is Associated With Low Levels of Soluble PD-L1 in Rheumatoid Arthritis

Autor: Caroline Wasén, Malin C. Erlandsson, Apostolos Bossios, Linda Ekerljung, Carina Malmhäll, Sofia Töyrä Silfverswärd, Rille Pullerits, Bo Lundbäck, Maria I. Bokarewa

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

BackgroundSmoking is a risk factor for developing rheumatoid arthritis (RA), but the mechanism remains uncertain. We previously demonstrated that smoking lowers the T cell activation threshold by limiting programmed death protein 1 (PD-1) expression.

Externí odkaz: https://doaj.org/article/9774a650d97049cb92e51f920ece0dc2

Insights into the Mechanism for Vertical Graphene Growth by Plasma-Enhanced Chemical Vapor Deposition

Autor: Jie Sun, Tanupong Rattanasawatesun, Penghao Tang, Zhaoxia Bi, Santosh Pandit, Lisa Lam, Caroline Wasén, Malin Erlandsson, Maria Bokarewa, Jichen Dong, Feng Ding, Fangzhu Xiong, Ivan Mijakovic

Publikováno v: Sun, J, Rattanasawatesun, T, Tang, P, Bi, Z, Pandit, S, Lam, L, Wasen, C, Erlandsson, M, Bokarewa, M, Dong, J, Ding, F, Xiong, F & Mijakovic, I 2022, ' Insights into the Mechanism for Vertical Graphene Growth by Plasma-Enhanced Chemical Vapor Deposition ', ACS Applied Materials and Interfaces, vol. 14, no. 5, pp. 7152–7160 . https://doi.org/10.1021/acsami.1c21640

Vertically oriented graphene (VG) has attracted attention for years, but the growth mechanism is still not fully revealed. The electric field may play a role, but the direct evidence and exactly what role it plays remains unclear. Here, we conduct a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cef5e076c88a1eabf730df20c83ee57
https://pubmed.ncbi.nlm.nih.gov/35005901