Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Caroline, Stetler"'
Autor:
Ya-Fei Xu, Mercedes Prudencio, Jaime M Hubbard, Jimei Tong, Ena C Whitelaw, Karen Jansen-West, Caroline Stetler, Xiangkun Cao, John Song, Yong-Jie Zhang
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69864 (2013)
Tar DNA binding protein 43 (TDP-43) is the major component of pathological deposits in frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) and in amyotrophic lateral sclerosis (ALS). It has been reported that TDP-43 transgenic mouse m
Externí odkaz:
https://doaj.org/article/9614c87237f4476facd0a0dec7799db4
Autor:
Mercedes Prudencio, Aishe Kurti, Jeannette N. Stankowski, Dennis W. Dickson, Linda Rousseau, Emilie A. Perkerson, Yong Jie Zhang, Tania F. Gendron, Ena C. Whitelaw, Dieter Edbauer, Peter O. Bauer, Karen Overstreet, Lillian M. Daughrity, Leonard Petrucelli, Pamela Desaro, Karen Jansen-West, Kevin F. Bieniek, John D. Fryer, Melissa E. Murray, Amelia Johnston, Rosa Rademakers, Monica Castanedes-Casey, Chris W. Lee, Hiroki Sasaguri, Caroline Stetler, Jeannie Chew, Kevin B. Boylan
Publikováno v:
Science
The major genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis is a G(4)C(2) repeat expansion in C9ORF72. Efforts to combat neurodegeneration associated with "c9FTD/ALS" are hindered by a lack of animal models recapitulating dis
Autor:
Michael DeTure, Mary D. Davis, Caroline Stetler, Leonard Petrucelli, Casey Cook, Dennis W. Dickson, Kristyn Scheffel, Matthew Jarpe, Judy Dunmore, Tania F. Gendron, Yari Carlomagno
Publikováno v:
Human Molecular Genetics
The accumulation of hyperphosphorylated tau in neurofibrillary tangles (NFTs) is a neuropathological hallmark of tauopathies, including Alzheimer's disease (AD) and chronic traumatic encephalopathy, but effective therapies directly targeting the tau
Publikováno v:
Brain Research. 1462:118-128
Frontotemporal lobar degeneration (FTLD), a neurodegenerative disease primarily affecting the frontal and temporal lobes, is one of the most common types of dementia. While the majority of FTLD cases are sporadic, approximately 10-40% of patients hav
Autor:
Christian A. Ross, Mary D. Davis, Sherri M. Biendarra, Marka van Blitterswijk, Mercedes Prudencio, Ralph B. Perkerson, Amelia E Piazza-Johnston, Caroline Stetler, Ranjan Batra, Kevin F. Bieniek, Karen Overstreet, Rosa Rademakers, Kevin B. Boylan, Leonard Petrucelli, Hu Li, Matt Baker, Christopher D. Link, Luc Pregent, Michael DeTure, Melissa E. Murray, Tania F. Gendron, Pamela Desaro, Veronique V. Belzil, Wing C. Lee, Dennis W. Dickson
Publikováno v:
Nature neuroscience
Increasing evidence suggests that defective RNA processing contributes to the development of amyotrophic lateral sclerosis (ALS). This may be especially true for ALS caused by a repeat expansion in C9orf72 (c9ALS), in which the accumulation of RNA fo
Autor:
Jeannie, Chew, Tania F, Gendron, Mercedes, Prudencio, Hiroki, Sasaguri, Yong-Jie, Zhang, Monica, Castanedes-Casey, Chris W, Lee, Karen, Jansen-West, Aishe, Kurti, Melissa E, Murray, Kevin F, Bieniek, Peter O, Bauer, Ena C, Whitelaw, Linda, Rousseau, Jeannette N, Stankowski, Caroline, Stetler, Lillian M, Daughrity, Emilie A, Perkerson, Pamela, Desaro, Amelia, Johnston, Karen, Overstreet, Dieter, Edbauer, Rosa, Rademakers, Kevin B, Boylan, Dennis W, Dickson, John D, Fryer, Leonard, Petrucelli
Publikováno v:
Science / Science now 348(6239), 1151-1154 (2015). doi:10.1126/science.aaa9344
The major genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis is a G4C2 repeat expansion in C9ORF72. Efforts to combat neurodegeneration associated with "c9FTD/ALS" are hindered by a lack of animal models recapitulating disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6b5a07fe5be13274ebfc8ab2239f3e33
Autor:
Peter O. Bauer, Yong Jie Zhang, Hiroki Sasaguri, Jeannie Chew, Karen Jansen-West, Mercedes Prudencio, Sandra Almeida, Tania F. Gendron, Thomas R. Caulfield, Leonard Petrucelli, William M. Tay, Ian R. A. Mackenzie, Fen-Biao Gao, Wing C. Lee, Caroline Stetler, Ni Cole A. Finch, Rosa Rademakers
Publikováno v:
Human molecular genetics
Human Molecular Genetics
Human Molecular Genetics
Progranulin (GRN) mutations causing haploinsufficiency are a major cause of frontotemporal lobar degeneration (FTLD-TDP). Recent discoveries demonstrating sortilin (SORT1) is a neuronal receptor for PGRN endocytosis and a determinant of plasma PGRN l
Autor:
Xiangkun Cao, Ena C. Whitelaw, Jimei Tong, Caroline Stetler, Yong Jie Zhang, Ya Fei Xu, Mercedes Prudencio, Karen Jansen-West, Jaime Hubbard, John Song
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 7, p e69864 (2013)
PLoS ONE, Vol 8, Iss 7, p e69864 (2013)
Tar DNA binding protein 43 (TDP-43) is the major component of pathological deposits in frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) and in amyotrophic lateral sclerosis (ALS). It has been reported that TDP-43 transgenic mouse m
Autor:
Tania F. Gendron, Hiroki Sasaguri, Wing C. Lee, Shuyi Cai, Thomas R. Caulfield, Caroline Stetler, Ena C. Whitelaw, Ya Fei Xu, Yong Jie Zhang, Jaime Hubbard, Leonard Petrucelli
Publikováno v:
Human Molecular Genetics
TAR DNA-binding protein-43 (TDP-43) is the principal component of ubiquitinated inclusions in amyotrophic lateral sclerosis (ALS) and the most common pathological subtype of frontotemporal dementia—frontotemporal lobar degeneration with TDP-43-posi
Autor:
Dennis W. Dickson, Luc Pregent, Tania F. Gendron, Leonard Petrucelli, Mercedes Prudencio, Lillian M. Daughrity, Kevin B. Boylan, Rosa Rademakers, Peter O. Bauer, Caroline Stetler, Tushar Patel, Matt Baker, Veronique V. Belzil, Irene K. Yan
Publikováno v:
Acta neuropathologica
Acta Neuropathologica
Acta Neuropathologica
Individuals carrying (GGGGCC) expanded repeats in the C9orf72 gene represent a significant portion of patients suffering from amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Elucidating how these expanded repeats cause “c9FTD