Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Caroline, Solas"'
Autor:
Paul-Rémi Petit, Franck Touret, Jean-Sélim Driouich, Maxime Cochin, Léa Luciani, Ornéllie Bernadin, Caroline Laprie, Géraldine Piorkowski, Laurent Fraisse, Peter Sjö, Charles E. Mowbray, Fanny Escudié, Ivan Scandale, Eric Chatelain, Xavier de Lamballerie, Caroline Solas, Antoine Nougairède
Publikováno v:
Heliyon, Vol 10, Iss 10, Pp e30862- (2024)
The SARS-CoV-2 pandemic has highlighted the need for broad-spectrum antiviral drugs to respond promptly to viral emergence. We conducted a preclinical study of molnupiravir (MOV) against SARS-CoV-2 to fully characterise its antiviral properties and m
Externí odkaz:
https://doaj.org/article/1a39566e56e64bfcb9d0d5134525713d
Autor:
Romain Marlin, Delphine Desjardins, Vanessa Contreras, Guillaume Lingas, Caroline Solas, Pierre Roques, Thibaut Naninck, Quentin Pascal, Sylvie Behillil, Pauline Maisonnasse, Julien Lemaitre, Nidhal Kahlaoui, Benoit Delache, Andrés Pizzorno, Antoine Nougairede, Camille Ludot, Olivier Terrier, Nathalie Dereuddre-Bosquet, Francis Relouzat, Catherine Chapon, Raphael Ho Tsong Fang, Sylvie van der Werf, Manuel Rosa Calatrava, Denis Malvy, Xavier de Lamballerie, Jeremie Guedj, Roger Le Grand
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Repurposed antiviral drugs present as a valuable resource in the defence during outbreaks, with rigorous evaluation in large animal models keys for translation to clinical implementation. Here, the authors explore the antiviral activity of favipiravi
Externí odkaz:
https://doaj.org/article/cee3e8b3e2194e7993477900e8552973
Autor:
Jean-Sélim Driouich, Maxime Cochin, Franck Touret, Paul-Rémi Petit, Magali Gilles, Grégory Moureau, Karine Barthélémy, Caroline Laprie, Thanaporn Wattanakul, Palang Chotsiri, Richard M. Hoglund, Joel Tarning, Laurent Fraisse, Peter Sjö, Charles E. Mowbray, Fanny Escudié, Ivan Scandale, Eric Chatelain, Xavier de Lamballerie, Caroline Solas, Antoine Nougairède
Publikováno v:
EBioMedicine, Vol 82, Iss , Pp 104148- (2022)
Summary: Background: To address the emergence of SARS-CoV-2, multiple clinical trials in humans were rapidly started, including those involving an oral treatment by nitazoxanide, despite no or limited pre-clinical evidence of antiviral efficacy. Meth
Externí odkaz:
https://doaj.org/article/2c868ce6fdee4c09b5bfe87564b64a94
Autor:
Jenny Becam, Edouard Martin, Gildas Pouradier, Natalia Doudka, Caroline Solas, Romain Guilhaumou, Nicolas Fabresse
Publikováno v:
Toxics, Vol 11, Iss 5, p 464 (2023)
We report a case of accidental nicotine intoxication following transdermal exposure in a 22-year-old man with no medical history, who worked in a company manufacturing e-liquids for electronic cigarettes. He accidentally spilled 300 mL of pure nicoti
Externí odkaz:
https://doaj.org/article/8ddf01db86114fa598f0314b48f3a722
Autor:
Jean-Sélim Driouich, Maxime Cochin, Guillaume Lingas, Grégory Moureau, Franck Touret, Paul-Rémi Petit, Géraldine Piorkowski, Karine Barthélémy, Caroline Laprie, Bruno Coutard, Jérémie Guedj, Xavier de Lamballerie, Caroline Solas, Antoine Nougairède
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Favipiravir has broad-spectrum antiviral activity against a variety of RNA viruses. Here the authors investigate the safety, pharmacokinetics and anti-SARS-CoV-2 efficacy of different drug dosage in the a Syrian hamster model of infection and, combin
Externí odkaz:
https://doaj.org/article/28b65fe72e8643d09a5316e736cd7471
Autor:
Clémence Marin, Anis Krache, Chloé Palmaro, Mathilde Lucas, Valentin Hilaire, Renée Ugdonne, Bénédicte De Victor, Sylvie Quaranta, Caroline Solas, Bruno Lacarelle, Joseph Ciccolini
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 4, Pp 761-768 (2020)
Detecting patients with dihydropyrimidine dehydrogenase (DPD) deficiency is becoming a major concern in clinical oncology. Monitoring physiologic plasma uracil and/or plasma uracil‐to‐dihydrouracil metabolic ratio is a common surrogate frequently
Externí odkaz:
https://doaj.org/article/863273e40aab44e7a9196b17925d03a8
Autor:
Antonio Gonçalves, Pauline Maisonnasse, Flora Donati, Mélanie Albert, Sylvie Behillil, Vanessa Contreras, Thibaut Naninck, Romain Marlin, Caroline Solas, Andres Pizzorno, Julien Lemaitre, Nidhal Kahlaoui, Olivier Terrier, Raphael Ho Tsong Fang, Vincent Enouf, Nathalie Dereuddre-Bosquet, Angela Brisebarre, Franck Touret, Catherine Chapon, Bruno Hoen, Bruno Lina, Manuel Rosa Calatrava, Xavier de Lamballerie, France Mentré, Roger Le Grand, Sylvie van der Werf, Jérémie Guedj
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 3, p e1008785 (2021)
Non-human primates infected with SARS-CoV-2 exhibit mild clinical signs. Here we used a mathematical model to characterize in detail the viral dynamics in 31 cynomolgus macaques for which nasopharyngeal and tracheal viral load were frequently assesse
Externí odkaz:
https://doaj.org/article/0fa0b9d2f5e5421e8a4721a215607b84
Autor:
Atakan Hernandez, Valerie Lacroze, Natalia Doudka, Jenny Becam, Carole Pourriere-Fabiani, Bruno Lacarelle, Caroline Solas, Nicolas Fabresse
Publikováno v:
Toxics, Vol 10, Iss 2, p 55 (2022)
The aim of this study was to develop and to validate a toxicological untargeted screening relying on LC-HRMS in meconium including the detection of the four main classes of drugs of abuse (DoA; amphetamines, cannabinoids, opioids and cocaine). The me
Externí odkaz:
https://doaj.org/article/e37cc435d4d84710be39033483cc6e82
Autor:
Vincent Madelain, Sylvain Baize, Frédéric Jacquot, Stéphanie Reynard, Alexandra Fizet, Stephane Barron, Caroline Solas, Bruno Lacarelle, Caroline Carbonnelle, France Mentré, Hervé Raoul, Xavier de Lamballerie, Jérémie Guedj
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Optimization of antiviral therapy can be crucial in the management of Ebola virus outbreaks. Here, Madelain et al. use an integrative mathematical model to correlate the dose and the time of treatment initiation with survival rate, enhanced immune re
Externí odkaz:
https://doaj.org/article/8007c9d9b043441c879ab95a1e9f13f9
Autor:
Christina Psomas, Sabine Kinloch, Caroline Sabin, Vicente Soriano, Caroline Solas, Chloe Orkin, José Bernardino, Adrian Curran, Jean-Pierre Routy, Patricia Enel, Patrick Philibert, Alain Lafeuillade
Publikováno v:
Journal of Virus Eradication, Vol 4, Iss 3, Pp 196-207 (2018)
The 20th International Symposium on HIV and Emerging Infectious Diseases took place in Marseille, France. It had a refreshing European look with reinforced partnerships with the European AIDS Clinical Society and the British HIV Association and with
Externí odkaz:
https://doaj.org/article/96c49ad6a316422dba1cf2d31cf8376a