Implementation of preemptive DNA sequence-based pharmacogenomics testing across a large academic medical center: The Mayo-Baylor RIGHT 10K Study

Autor: Liewei Wang, Steven E. Scherer, Suzette J. Bielinski, Donna M. Muzny, Leila A. Jones, John Logan Black, Ann M. Moyer, Jyothsna Giri, Richard R. Sharp, Eric T. Matey, Jessica A. Wright, Lance J. Oyen, Wayne T. Nicholson, Mathieu Wiepert, Terri Sullard, Timothy B. Curry, Carolyn R. Rohrer Vitek, Tammy M. McAllister, Jennifer L. St. Sauver, Pedro J. Caraballo, Konstantinos N. Lazaridis, Eric Venner, Xiang Qin, Jianhong Hu, Christie L. Kovar, Viktoriya Korchina, Kimberly Walker, HarshaVardhan Doddapaneni, Tsung-Jung Wu, Ritika Raj, Shawn Denson, Wen Liu, Gauthami Chandanavelli, Lan Zhang, Qiaoyan Wang, Divya Kalra, Mary Beth Karow, Kimberley J. Harris, Hugues Sicotte, Sandra E. Peterson, Amy E. Barthel, Brenda E. Moore, Jennifer M. Skierka, Michelle L. Kluge, Katrina E. Kotzer, Karen Kloke, Jessica M. Vander Pol, Heather Marker, Joseph A. Sutton, Adrijana Kekic, Ashley Ebenhoh, Dennis M. Bierle, Michael J. Schuh, Christopher Grilli, Sara Erickson, Audrey Umbreit, Leah Ward, Sheena Crosby, Eric A. Nelson, Sharon Levey, Michelle Elliott, Steve G. Peters, Naveen Pereira, Mark Frye, Fadi Shamoun, Matthew P. Goetz, Iftikhar J. Kullo, Robert Wermers, Jan A. Anderson, Christine M. Formea, Razan M. El Melik, John D. Zeuli, Joseph R. Herges, Carrie A. Krieger, Robert W. Hoel, Jodi L. Taraba, Scott R. St. Thomas, Imad Absah, Matthew E. Bernard, Stephanie R. Fink, Andrea Gossard, Pamela L. Grubbs, Therese M. Jacobson, Paul Takahashi, Sharon C. Zehe, Susan Buckles, Michelle Bumgardner, Colette Gallagher, Kelliann Fee-Schroeder, Nichole R. Nicholas, Melody L. Powers, Ahmed K. Ragab, Darcy M. Richardson, Anthony Stai, Jaymi Wilson, Joel E. Pacyna, Janet E. Olson, Erica J. Sutton, Annika T. Beck, Caroline Horrow, Krishna R. Kalari, Nicholas B. Larson, Hongfang Liu, Liwei Wang, Guilherme S. Lopes, Bijan J. Borah, Robert R. Freimuth, Ye Zhu, Debra J. Jacobson, Matthew A. Hathcock, Sebastian M. Armasu, Michaela E. McGree, Ruoxiang Jiang, Tyler H. Koep, Jason L. Ross, Matthew G. Hilden, Kathleen Bosse, Bronwyn Ramey, Isabelle Searcy, Eric Boerwinkle, Richard A. Gibbs, Richard M. Weinshilboum

Publikováno v: Genet Med

PURPOSE: The Mayo-Baylor RIGHT 10K Study enabled preemptive, sequence-based pharmacogenomics (PGx)-driven drug prescribing practices in routine clinical care within a large cohort. We also generated the tools and resources necessary for clinical PGx

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d355d871839420df942f373e190f5c
https://pubmed.ncbi.nlm.nih.gov/35331649

Should pretest genetic counselling be required for patients pursuing genomic sequencing? Results from a survey of participants in a large genomic implementation study

Autor: Carmen Radecki Breitkopf, Joel E. Pacyna, Richard R. Sharp, Iftikhar J. Kullo, Erica J. Sutton, Sarah M. Jenkins, Caroline Horrow

Publikováno v: J Med Genet

PurposeWe assessed the decision-making of individuals pursuing genomic sequencing without a requirement for pretest genetic counselling. We sought to describe the extent to which individuals who decline genetic counselling reported decisional conflic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a65db63b590c87f2979fe25e01c79ad
https://doi.org/10.1136/jmedgenet-2018-105577

Design and Pilot Testing of an English and Spanish Behavioral Health Patient Survey on Data Privacy

Autor: Marcela P, Aliste, Adela, Grando, Anita, Murcko, Hiral, Soni, Michael, Todd, Madhumita, Mukundan, Michael, Saks, Caroline, Horrow, Richard, Sharp, Christy, Dye, Darwyn, Chern, Mary Jo, Whitfield, Mark, Callesen

Publikováno v: Studies in health technology and informatics. 264

We piloted a Spanish and English survey on data privacy. Thirty-one Latino behavioral health patients completed the survey in person with a preference for paper (78%) over electronic questionnaire. Dialect variations across Latino countries and the l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c3f83d4798a13f59b6b03a819d905f9c
https://pubmed.ncbi.nlm.nih.gov/31438393

Author response for 'Assessing optimism and pessimism about genomic medicine: Development of a Genomic Orientation (GO) scale'

Autor: null Caroline Horrow, null Joel Pacyna, null Erica Sutton, null Beau P. Sperry, null Carmen Radecki Breitkopf, null Richard R. Sharp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2aa9b12a802de288a302cf9a8132ea33
https://doi.org/10.1111/cge.13535/v3/response1

Confronting High Costs And Clinical Uncertainty: Innovative Payment Models For Gene Therapies.

Autor: Horrow C; Caroline Horrow, Brigham and Women's Hospital, Boston, Massachusetts., Kesselheim AS; Aaron S. Kesselheim (akesselheim@bwh.harvard.edu), Brigham and Women's Hospital.

Publikováno v: Health affairs (Project Hope) [Health Aff (Millwood)] 2023 Nov; Vol. 42 (11), pp. 1532-1540.