Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Caroline, Desponts"'
Publikováno v:
PLoS ONE, Vol 3, Iss 10, p e3565 (2008)
The SH2-containing-5'inositol phosphatase-1 (SHIP) influences signals downstream of cytokine/chemokine receptors that play a role in megakaryocytopoiesis, including thrombopoietin, stromal-cell-derived-Factor-1/CXCL-12 and interleukin-3. We hypothesi
Externí odkaz:
https://doaj.org/article/c11661b05fa3438588b2a69428d0c924
Autor:
Daniel S. Lorrain, Jonah R. Chan, Kelsey Rankin, Sonia R. Mayoral, Ari J. Green, Sergio E. Baranzini, Riley Bove, Kicheol Kim, Yun-An A Shen, Caroline Desponts, Feng Mei
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 39, iss 12
A significant unmet need for patients with multiple sclerosis (MS) is the lack of U.S. Food and Drug Administration (FDA)-approved remyelinating therapies. We have identified a compelling remyelinating agent, bazedoxifene (BZA), a European Medicines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e38e0b220e3bf6b8bb019244ca101d2
https://escholarship.org/uc/item/969099jq
https://escholarship.org/uc/item/969099jq
Autor:
Feng Mei, Jonah R. Chan, Daniel S. Lorrain, Jennifer L. Whistler, Caroline Desponts, David H. Rowitch, Ari J. Green, Sonia R. Mayoral, Hiroko Nobuta, Lan Xiao, Fei Wang
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 36, iss 30
UnlabelledRemyelinating therapies seek to promote restoration of function and normal cellular architecture following demyelination in diseases, such as multiple sclerosis (MS). Functional screening for small molecules or novel targets for remyelinati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b4e5cc648c5596c59850f2a7e277782
https://pubmed.ncbi.nlm.nih.gov/27881770
https://pubmed.ncbi.nlm.nih.gov/27881770
Autor:
Gary J. Patti, Caroline Desponts, Sunia A. Trauger, Gary Siuzdak, Sheng Ding, Antonio Sánchez-Ruiz, Julie Clark, Diana M. Wong, Oscar Yanes, H. Paul Benton
Publikováno v:
Nature chemical biology
Metabolites offer an important unexplored complement to understanding the pluripotency of stem cells. Using mass spectrometry-based metabolomics, we show that embryonic stem cells are characterized by abundant metabolites with highly unsaturated stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ef29ed15995d1bfcaa2bb738e221d2
http://europepmc.org/articles/PMC2873061
http://europepmc.org/articles/PMC2873061
Autor:
Amy L. Hazen, Oliver Winter, Caroline Desponts, Michelle J. Smith, Katrin Moser, William G. Kerr
Publikováno v:
Blood. 113:2924-2933
SH2-domain-containing inositol 5′-phosphatase-1 (SHIP) deficiency significantly increases the number of hematopoietic stem cells (HSCs) present in the bone marrow (BM). However, the reconstitution capacity of these HSCs is severely impaired, sugges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7890782c36a63b92afab15e73f969509
https://doi.org/10.1182/blood-2008-02-138008
https://doi.org/10.1182/blood-2008-02-138008
Publikováno v:
Cell Stem Cell. 3:568-574
SummarySomatic cells can be induced into pluripotent stem cells (iPSCs) with a combination of four transcription factors, Oct4/Sox2/Klf4/c-Myc or Oct4/Sox2/Nanog/LIN28. This provides an enabling platform to obtain patient-specific cells for various t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc4e2ac4885d5e2bff7bb31ec2eb72e2
https://doi.org/10.1016/j.stem.2008.10.004
https://doi.org/10.1016/j.stem.2008.10.004
Publikováno v:
Blood. 107:4338-4345
The SH2 domain–containing inositol 5′-phosphatase-1 (SHIP) has the potential to modulate multiple signaling pathways downstream of receptors that impact hematopoietic stem cell (HSC) biology. Therefore, we postulated that SHIP might play an impor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b256916f87b99c20d1997944b35f20fc
https://doi.org/10.1182/blood-2005-12-5021
https://doi.org/10.1182/blood-2005-12-5021
Autor:
Caroline Desponts, Ernest Asante-Appiah, Yves Leblanc, Brian P. Kennedy, Sangita B. Patel, Claude Dufresne, Cheuk K. Lau, R. W. Friesen, Giovanna Scapin, Joseph W. Becker, Jillian M. Taylor, Michel Therien
Publikováno v:
Journal of Biological Chemistry. 281:8010-8015
PTP-1B represents an attractive target for the treatment of type 2 diabetes and obesity. Given the role that protein phosphatases play in the regulation of many biologically relevant processes, inhibitors against PTP-1B must be not only potent, but a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c540ae1c13d462238e7eaec6e783eea
https://doi.org/10.1074/jbc.m511827200
https://doi.org/10.1074/jbc.m511827200
Autor:
John M. Ninos, Tomar Ghansah, Jason Brayer, Caroline Desponts, Eduardo M. Sotomayor, Sarah May, Fengdong Cheng, William G. Kerr, Steven L. Highfill, Jia-Wang Wang, Kim H. T. Paraiso, Joseph K. McIntosh
Publikováno v:
Scopus-Elsevier
Previously we demonstrated that SHIP−/− mice accept allogeneic bone marrow transplants (BMT) without significant acute graft-vs-host disease (GvHD). In this study we show that SHIP−/− splenocytes and lymph node cells are poor stimulators of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc6b981d0ce21b03df29bf56f6f9ee5d
https://doi.org/10.4049/jimmunol.173.12.7324
https://doi.org/10.4049/jimmunol.173.12.7324
Autor:
Stefano, Volinia, Gerard, Nuovo, Alessandra, Drusco, Stefan, Costinean, Ramzey, Abujarour, Caroline, Desponts, Michela, Garofalo, Raffaele, Baffa, Rami, Aeqilan, Kati, Maharry, Maria Elena, Sana, Maria Elena Sana Ramiro, Garzon, Gianpiero, Di Leva, Pierluigi, Gasparini, Paola, Dama, Jlenia, Marchesini, Marco, Galasso, Marco, Manfrini, Carlotta, Zerbinati, Fabio, Corrà, Timothy, Wise, Sylwia E, Wojcik, Maurizio, Previati, Flavia, Pichiorri, Nicola, Zanesi, Hansjuerg, Alder, Jeff, Palatini, Kay F, Huebner, Charles L, Shapiro, Massimo, Negrini, Andrea, Vecchione, Anne L, Rosenberg, Carlo M, Croce, Ramiro, Garzon
Publikováno v:
Journal of the National Cancer Institute. 106(12)
Background The purpose of this study is to determine whether microRNA for pluripotent stem cells are also expressed in breast cancer and are associated with metastasis and outcome. Methods We studied global microRNA profiles during differentiation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e512fb5e0fabf6a401bf7915d47001e1
https://pubmed.ncbi.nlm.nih.gov/25306216
https://pubmed.ncbi.nlm.nih.gov/25306216