Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Carolina S. Ilkow"'
Autor:
Lilia Antonova, Piriya Paramanthan, Theresa Falls, Marie-Eve Wedge, Justin Mayer, Harman S. Sekhon, John McPherson, Robert E. Denroche, Steven Gallinger, John Cameron Bell, Carolina S. Ilkow, Avijit Chatterjee
Publikováno v:
Cancers, Vol 16, Iss 15, p 2721 (2024)
Pancreatic cancer has one of the worst prognoses among all malignancies and few available treatment options. Patient-derived xenografts can be used to develop personalized therapy for pancreatic cancer. Endoscopic ultrasound fine-needle aspiration (E
Externí odkaz:
https://doaj.org/article/24b9b6554a114c09b02c82f03e09572a
Autor:
Carolina S. Ilkow, John Cameron Bell
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/4b6ec52a52ea461ca3da36f82aaf7826
Autor:
Taha Azad, Reza Rezaei, Ragunath Singaravelu, Adrian Pelin, Stephen Boulton, Julia Petryk, Kemal Alper Onsu, Nikolas T. Martin, Victoria Hoskin, Mina Ghahremani, Marie Marotel, Ricardo Marius, Xiaohong He, Mathieu J. F. Crupi, Huy-Dung Hoang, Abolfazl Nik-Akhtar, Mahsa Ahmadi, Nika Kooshki Zamani, Ashkan Golshani, Tommy Alain, Peter Greer, Michele Ardolino, Bryan C. Dickinson, Lee-Hwa Tai, Carolina S. Ilkow, John C. Bell
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The large coding potential of vaccinia virus (VV) vectors is a defining feature. However, limited regulatory switches are available to control viral replication as well as timing and dosing of transgene expression in order to facilitate safe
Externí odkaz:
https://doaj.org/article/ac9b0514948d4425b5c222c2feb15ba2
Autor:
Stephen Boulton, Joanna Poutou, Rida Gill, Nouf Alluqmani, Xiaohong He, Ragunath Singaravelu, Mathieu J.F. Crupi, Julia Petryk, Bradley Austin, Leonard Angka, Zaid Taha, Iris Teo, Siddarth Singh, Rameen Jamil, Ricardo Marius, Nikolas Martin, Taylor Jamieson, Taha Azad, Jean-Simon Diallo, Carolina S. Ilkow, John C. Bell
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101110- (2023)
SARS-CoV-2, the etiological agent behind the coronavirus disease 2019 (COVID-19) pandemic, has continued to mutate and create new variants with increased resistance against the WHO-approved spike-based vaccines. With a significant portion of the worl
Externí odkaz:
https://doaj.org/article/3db94dba202d4816898f54399e85392a
Autor:
Zaid Taha, Mathieu J.F. Crupi, Nouf Alluqmani, Faiha Fareez, Kristy Ng, Judy Sobh, Emily Lee, Andrew Chen, Max Thomson, Marcus M. Spinelli, Carolina S. Ilkow, John C. Bell, Rozanne Arulanandam, Jean-Simon Diallo
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundEstablished mouse models of HER2+ cancer are based on the over-expression of rodent Neu/Erbb2 homologues, which are incompatible with human HER2 (huHER2) targeted therapeutics. Additionally, the use of immune-deficient xenograft or transgen
Externí odkaz:
https://doaj.org/article/1dada88ac70547d481073fd252694be0
Autor:
Abera Surendran, Monire Jamalkhah, Joanna Poutou, Rayanna Birtch, Christine Lawson, Jaahnavi Dave, Mathieu J. F. Crupi, Justin Mayer, Victoria Taylor, Julia Petryk, Christiano Tanese de Souza, Neil Moodie, Jacob Lecompte Billingsley, Bradley Austin, Nicole Cormack, Natalie Blamey, Reza Rezaei, Curtis W. McCloskey, Emily E. F. Fekete, Harsimrat K. Birdi, Serge Neault, Taylor R. Jamieson, Brenna Wylie, Sarah Tucker, Taha Azad, Barbara Vanderhyden, Lee-Hwa Tai, John C. Bell, Carolina S. Ilkow
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionAdipocytes in the tumour microenvironment are highly dynamic cells that have an established role in tumour progression, but their impact on anti-cancer therapy resistance is becoming increasingly difficult to overlook.MethodsWe investigat
Externí odkaz:
https://doaj.org/article/6f4b17f759de414f8da10ac2aa3a216f
Autor:
Marie-Eve Wedge, Victoria A. Jennings, Mathieu J. F. Crupi, Joanna Poutou, Taylor Jamieson, Adrian Pelin, Giuseppe Pugliese, Christiano Tanese de Souza, Julia Petryk, Brian J. Laight, Meaghan Boileau, Zaid Taha, Nouf Alluqmani, Hayley E. McKay, Larissa Pikor, Sarwat Tahsin Khan, Taha Azad, Reza Rezaei, Bradley Austin, Xiaohong He, David Mansfield, Elaine Rose, Emily E. F. Brown, Natalie Crawford, Almohanad Alkayyal, Abera Surendran, Ragunath Singaravelu, Dominic G. Roy, Gemma Migneco, Benjamin McSweeney, Mary Lynn Cottee, Egon J. Jacobus, Brian A. Keller, Takafumi N. Yamaguchi, Paul C. Boutros, Michele Geoffrion, Katey J. Rayner, Avijit Chatterjee, Rebecca C. Auer, Jean-Simon Diallo, Derrick Gibbings, Benjamin R. tenOever, Alan Melcher, John C. Bell, Carolina S. Ilkow
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
RNA-based viruses can be engineered to express artificial microRNAs (amiRNAs). Here, the authors identify a candidate amiRNA that confers a replicative advantage to oncolytic viruses, enhancing their anticancer potency, and show that intercellular tr
Externí odkaz:
https://doaj.org/article/4c63ee51ae0d403a99532dab542cb349
Autor:
Coby Rangsitratkul, Christine Lawson, Francis Bernier-Godon, Seyedeh-Raheleh Niavarani, Marie Boudaud, Samuel Rouleau, Antoine-Olivier Gladu-Corbin, Abera Surendran, Nadia Ekindi-Ndongo, Madhuri Koti, Carolina S. Ilkow, Patrick O. Richard, Lee-Hwa Tai
Publikováno v:
Molecular Therapy: Oncolytics, Vol 24, Iss , Pp 507-521 (2022)
A significant proportion of non-muscle invasive bladder cancer cases will progress to muscle invasive disease. Transurethral resection followed by Bacillus Calmette Guerin immunotherapy can reduce this risk, while cystectomy prior to muscle invasion
Externí odkaz:
https://doaj.org/article/e326f3e5d29e4b4e998ce5184d61aeb6
Autor:
Jack T. Whelan, Ragunath Singaravelu, Fuan Wang, Adrian Pelin, Levi A. Tamming, Giuseppe Pugliese, Nikolas T. Martin, Mathieu J. F. Crupi, Julia Petryk, Bradley Austin, Xiaohong He, Ricardo Marius, Jessie Duong, Carter Jones, Emily E. F. Fekete, Nouf Alluqmani, Andrew Chen, Stephen Boulton, Michael S. Huh, Matt Y. Tang, Zaid Taha, Elena Scut, Jean-Simon Diallo, Taha Azad, Brian D. Lichty, Carolina S. Ilkow, John C. Bell
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
Poxvirus vectors represent versatile modalities for engineering novel vaccines and cancer immunotherapies. In addition to their oncolytic capacity and immunogenic influence, they can be readily engineered to express multiple large transgenes. However
Externí odkaz:
https://doaj.org/article/f7cfd3f77d384dec8678da5baade9481
Autor:
Mathieu J. F. Crupi, Zaid Taha, Thijs J. A. Janssen, Julia Petryk, Stephen Boulton, Nouf Alluqmani, Anna Jirovec, Omar Kassas, Sarwat T. Khan, Sydney Vallati, Emily Lee, Ben Zhen Huang, Michael Huh, Larissa Pikor, Xiaohong He, Ricardo Marius, Bradley Austin, Jessie Duong, Adrian Pelin, Serge Neault, Taha Azad, Caroline J. Breitbach, David F. Stojdl, Michael F. Burgess, Scott McComb, Rebecca Auer, Jean-Simon Diallo, Carolina S. Ilkow, John Cameron Bell
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Colorectal cancer is the third most diagnosed cancer and the second leading cause of cancer mortality worldwide, highlighting an urgent need for new therapeutic options and combination strategies for patients. The orchestration of potent T cell respo
Externí odkaz:
https://doaj.org/article/29d21675c815413ebbf0f96fc31a0567