Výsledky vyhledávání - "Carolina Rubel"

Protective role of nitric oxide in mice with Shiga toxin-induced hemolytic uremic syndrome

Autor: Gabriela C. Fernández, Sonia A. Gómez, Marina S. Palermo, Graciela Dran, Carolina Rubel, Emilse Bermejo, Martín A. Isturiz, Roberto Meiss

Publikováno v: Kidney International. 62(4):1338-1348

Background : Nitric oxide (NO) is an endogenous vasodilator and platelet inhibitor. An enhanced NO production has been detected in patients with hemolytic uremic syndrome (HUS), although its implication in HUS pathogenesis has not been clarified. Met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42dac712c1249a607177fe2d68a82ce

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Rapid recovery of platelet count following administration of liposome-encapsulated clodronate in a mouse model of immune thrombocytopenia

Autor: Nico van Rooijen, Carolina Rubel, Marina S. Palermo, Carmen Stanganelli, Juana Cabrera, Fernanda Alves-Rosa, Martín A. Isturiz, Dora Cymberknop, Silvia Vanzulli

Publikováno v: British Journal of Haematology. 116:357-366

Summary. Immune thrombocytopenic purpura (ITP) is a haematological disorder characterized by increased platelet consumption. The destruction of platelets is mediated by the reticulo-endothelial system (RES), particularly by splenic and hepatic macrop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ac1c7acb6788d8a6488f27da0e6d6aa
https://doi.org/10.1046/j.1365-2141.2002.03281.x

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Fibrinogen Promotes Neutrophil Activation and Delays Apoptosis

Autor: Gabriela C. Fernández, Graciela Dran, Marina S. Palermo, Carolina Rubel, Martín A. Isturiz, Macarena Beigier Bompadre

Publikováno v: The Journal of Immunology. 166:2002-2010

The acute phase of the inflammatory response involves an increase in the concentrations of different plasma proteins that include fibrinogen (Fbg) and multiple proinflammatory mediators. In parallel, neutrophil activation is thought to play a crucial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5bce10e00849085daa86516319be34
https://doi.org/10.4049/jimmunol.166.3.2002

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Pretreatment of mice with lipopolysaccharide (LPS) or IL-1β exerts dose-dependent opposite effects on Shiga toxin-2 lethality

Autor: Gabriela C. Fernández, Carolina Rubel, Martín A. Isturiz, F. Alberto, M. Rivas, F. Alves-Rosa, G. Fernández-Alonso, Marina S. Palermo

Publikováno v: Clinical and Experimental Immunology. 119:77-83

SUMMARY Haemolytic uraemic syndrome (HUS) has been closely associated with infection with a group of Shiga toxin-producing enterohaemorrhagic Eschericchia coli in young children. Shiga toxins (Stx) have been implicated as pathogenic agents of HUS by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c28921d49e1332f2a7f4b607034bb9a
https://doi.org/10.1046/j.1365-2249.2000.01103.x

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Development of DNA vaccines against hemolytic-uremic syndrome in a murine model

Autor: Alejandra Victoria Capozzo, Martín A. Isturiz, Virginia Pistone Creydt, Cristina Ibarra, Gabriela C. Fernández, Leticia V. Bentancor, Carolina Rubel, Graciela Dran, Marina S. Palermo, Sonia A. Gómez

Shiga toxin type 2 (Stx2) produced by Escherichia coli O:157H7 can cause hemolytic-uremic syndrome in children, a disease for which there is neither a vaccine nor an effective treatment. This toxin consists of an enzymatically active A subunit and a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ef8f686cb62519f7b1a77c465f1aa6
https://iai.asm.org/content/71/7/3971

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Fibrinogen-CD11b/CD18 interaction activates the NF-kappa B pathway and delays apoptosis in human neutrophils

Autor: Marina S. Palermo, Gabriela C. Fernández, Sonia A. Gómez, Carolina Rubel, Jorge Caamano, Martín A. Isturiz

Publikováno v: European journal of immunology. 33(5)

The regulation of neutrophil half-life by members of the coagulation cascade is critical for the resolution of the inflammatory response. We have demonstrated that soluble fibrinogen (sFbg) delays human neutrophil (PMN) apoptosis through a mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a895442e90165e7d393c8bb966b94ede
https://pubmed.ncbi.nlm.nih.gov/12731070

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The formyl peptide N-formyl-methionyl-leucyl-phenylalanine downregulates the expression of FcgammaRs in interferon-gamma-activated monocytes/macrophages in vitro and in vivo

Autor: Marina S. Palermo, Macarena Beigier-Bompadre, F. Alves-Rosa, Paula Barrionuevo, Martín A. Isturiz, Carolina Rubel

Publikováno v: Scandinavian journal of immunology. 57(3)

N-Formyl peptides are cleavage products of bacterial and mitochondrial proteins that have pro-inflammatory activities and play an important role in antibacterial host defence. FcgammaRI is a receptor for the Fc portion of immunoglobulin G expressed i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188c74e060dd250bb7b1de3cf3757d25
https://pubmed.ncbi.nlm.nih.gov/12641650

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Endogenous glucocorticoids attenuate Shiga toxin-2-induced toxicity in a mouse model of haemolytic uraemic syndrome

Autor: Gabriela C. Fernández, Marina S. Palermo, T. Berki, Graciela Dran, Silvia Vanzulli, Martín A. Isturiz, Carolina Rubel, Sonia A. Gómez

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

The concept that during an immune challenge the release of glucocorticoids (GC) provides feedback inhibition on evolving immune responses has been drawn primarily from studies of autoimmune and/or inflammatory processes in animal models. The epidemic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1847a84ab8bdf8bf908b91e6054c5fe
Wiley Online Library

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