Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Carolina Rosselot"'
Autor:
Randy B. Kang, Yansui Li, Carolina Rosselot, Tuo Zhang, Mustafa Siddiq, Prashant Rajbhandari, Andrew F. Stewart, Donald K. Scott, Adolfo Garcia-Ocana, Geming Lu
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-24 (2023)
Abstract Background Single-cell RNA sequencing (scRNA-seq) provides valuable insights into human islet cell types and their corresponding stable gene expression profiles. However, this approach requires cell dissociation that complicates its utility
Externí odkaz:
https://doaj.org/article/16b1eb06924e409ea8786e29877b0d8e
Autor:
Lucie Yammine, Belén Picatoste, Nazish Abdullah, Rosemary A. Leahey, Emma F. Johnson, Nicolás Gómez-Banoy, Carolina Rosselot, Jennifer Wen, Tahmina Hossain, Marcus D. Goncalves, James C. Lo, Adolfo Garcia-Ocaña, Timothy E. McGraw
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101831- (2023)
Objective: Glucose-dependent insulinotropic polypeptide (GIP) has a role in controlling postprandial metabolic tone. In humans, a GIP receptor (GIPR) variant (Q354, rs1800437) is associated with a lower body mass index (BMI) and increased risk for Ty
Externí odkaz:
https://doaj.org/article/08e30cb16fb344d1bf22ff6b6349e352
Autor:
Alexandra Alvarsson, Maria Jimenez-Gonzalez, Rosemary Li, Carolina Rosselot, Nikolaos Tzavaras, Zhuhao Wu, Sarah Stanley
Publikováno v:
Bio-Protocol, Vol 11, Iss 15 (2021)
The pancreas is a heavily innervated organ, but pancreatic innervation can be challenging to comprehensively assess using conventional histological methods. However, recent advances in whole-mount tissue clearing and 3D rendering techniques have allo
Externí odkaz:
https://doaj.org/article/6859ab640ac44afda26fcce548d61852
Publikováno v:
Diabetes. 71
Single-cell RNA sequencing (scRNA-seq) of human islets requires cell dissociation and does not provide information on the transcriptional status of islet cells. On the other hand, single-nucleus RNA sequencing (snRNA-seq) does not require cell dissoc
Autor:
KARA A. BELIARD, CAROLINA ROSSELOT, YANSUI LI, ALEXANDRA ALVARSSON, PENG WANG, KEYA THAKKAR, DANIELA GUEVARA, ROBERT J. DEVITA, ANDREW F. STEWART, SARAH STANLEY, ADOLFO GARCIA-OCANA
Publikováno v:
Diabetes. 71
Diabetes results from diminished functional β-cell mass. Small molecule inhibitors of Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A) markedly increase human β-cell replication in vitro and in vivo. Furthermore, combination o
Autor:
CAROLINA ROSSELOT, YANSUI LI, DANIELA GUEVARA, KARA A. BELIARD, RANDY KANG, PENG WANG, KEYA THAKKAR, GEMING LU, ROBERT J. DEVITA, ANDREW F. STEWART, ADOLFO GARCIA-OCANA
Publikováno v:
Diabetes. 71
GLP1R agonists such as Exendin-4 (E) together with DYRK1A inhibitors such as Harmine (H) significantly increase human β-cell replication in vitro and in vivo. Importantly, 3-month treatment with H+E combination markedly increases human beta cell mas
Autor:
GEMING LU, RANDY KANG, YANSUI LI, PENG WANG, CAROLINA ROSSELOT, ROBERT J. DEVITA, ANDREW F. STEWART, ADOLFO GARCIA-OCANA
Publikováno v:
Diabetes. 71
Type 1 diabetes (T1D) results from loss of both immune tolerance and functional β-cells. Administration of harmine (H) plus exendin-4 (E) markedly induces human β-cell expansion. Anti-CD3 antibody treatment reduces C-peptide loss in T1D patients. H
Autor:
Randy B. Kang, Yansui Li, Carolina Rosselot, Tuo Zhang, Mustafa Siddiq, Prashant Rajbhandari, Andrew F. Stewart, Donald K. Scott, Adolfo Garcia-Ocana, Geming Lu
Single-cell RNA sequencing (scRNA-seq) has provided valuable insights into human islet cell types and their corresponding stable gene expression profiles. However, this approach requires cell dissociation that complicates its utility in vivo and prov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f987db34a5ec4d398a3bbd9d0048a5c
https://doi.org/10.1101/2022.05.22.492974
https://doi.org/10.1101/2022.05.22.492974
Autor:
Gregory H. Bird, Accalia Fu, Jarrod A. Marto, A. M. James Shapiro, Loren D. Walensky, Mehmet G. Badur, Scott B. Ficarro, Lindsay Evans, Andrew F. Stewart, Dong Wook Choi, Russell G. Jones, Gaëlle Bridon, Nika N. Danial, Adolfo Garcia-Ocaña, Carolina Rosselot, Daina Avizonis, Hyuk-Soo Seo, Tatsuya Kin, Juan Carlos Alvarez-Perez, Sirano Dhe-Paganon, Esra Karakose, Jurre J. Kamphorst
Publikováno v:
Nature metabolism
Chronic inflammation is linked to diverse disease processes, but the intrinsic mechanisms that determine cellular sensitivity to inflammation are incompletely understood. Here, we show the contribution of glucose metabolism to inflammation-induced ch
Autor:
Zhuhao Wu, Rosemary Li, Maria Jimenez-Gonzalez, Nikolaos Tzavaras, Carolina Rosselot, Alexandra Alvarsson, Sarah A. Stanley
Publikováno v:
Bio Protoc
The pancreas is a heavily innervated organ, but pancreatic innervation can be challenging to comprehensively assess using conventional histological methods. However, recent advances in whole-mount tissue clearing and 3D rendering techniques have allo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcedb6389306855b09d28c3dc9f2752f
https://europepmc.org/articles/PMC8376577/
https://europepmc.org/articles/PMC8376577/