Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Carolina Perez-Pastene"'
Autor:
Christian Arriagada, Irmgard Paris, Maria Jose Sanchez de las Matas, Pedro Martinez-Alvarado, Sergio Cardenas, Patricia Castañeda, Rebecca Graumann, Carolina Perez-Pastene, Claudio Olea-Azar, Eduardo Couve, Maria T Herrero, Pablo Caviedes, Juan Segura-Aguilar
Publikováno v:
Neurobiology of Disease, Vol 16, Iss 2, Pp 468-477 (2004)
Leukoaminochrome o-semiquinone radical is generated during one-electron reduction of dopamine oxidation product aminochrome when DT-diaphorase is inhibited. Incubation of 100 μM aminochrome with 100 μM dicoumarol, an inhibitor of DT-diaphorase duri
Externí odkaz:
https://doaj.org/article/51ddb98566134ccbaf0fd4b4fab79f61
Publikováno v:
NEUROTOXICITY RESEARCH
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Oxidation of dopamine to aminochrome seems to be a normal process leading to aminochrome polymerization to form neuromelanin, since normal individuals have this pigment in their dopaminergic neurons in the substantia nigra. The neurons lost in indivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d95a7eeb0cab128ca956889640dbe0
https://doi.org/10.1007/s12640-009-9059-4
https://doi.org/10.1007/s12640-009-9059-4
Autor:
Fernando Díaz-Grez, Luis Lay-Son, Juan Segura-Aguilar, Jennifer M. Kachergus, Pablo Venegas, Carolina Perez-Pastene, Matthew J. Farrer, Owen A. Ross, Stephanie A. Cobb, Osvaldo Trujillo Godoy, Mary M. Hulihan, Marcelo Miranda
Publikováno v:
Neuroscience Letters. 422:193-197
Pathogenic substitutions in the leucine-rich repeat kinase 2 protein (Lrrk2), R1441G and G2019S, are a prevalent cause of autosomal dominant and sporadic Parkinson's disease in the Northern Spanish population. In this study we examined the frequency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae7b64425fafa3c75214b3d77f6038d8
https://doi.org/10.1016/j.neulet.2007.06.021
https://doi.org/10.1016/j.neulet.2007.06.021
Autor:
Jorge Lozano, Juan Segura-Aguilar, Alejandra Riveros, Irmgard Paris, Pablo Caviedes, Sergio Cardenas, Rebecca Graumann, Carolina Perez-Pastene
Publikováno v:
Neurotoxicity Research. 12:125-134
Four decades after L-dopa introduction to PD therapy, the cause of Parkinson’s disease (PD) remains unknown despite the intensive research and the discovery of a number of gene mutations and delections in the pathogenesis of familial PD. Different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbe33046caf24885f52fba0c7eddbce
https://doi.org/10.1007/bf03033921
https://doi.org/10.1007/bf03033921
Autor:
Juan Segura-Aguilar, Fernando Díaz-Grez, Luis Lay-Son, Marcelo Miranda, Carolina Perez-Pastene, Pablo Venegas, Rebecca Graumann, Luisa Herrera, Osvaldo Trujillo Godoy, Roque Villagra, José Manuel Matamala
Publikováno v:
Neuroscience Letters. 418:181-185
We have studied the association of a null mutation of Glutathione Transferase M1 (GST M1*0/0) with Parkinson's disease (MIM 168600) in a Chilean population with a strong Amerindian genetic component. We determined the genotype in 349 patients with id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4edc6aae32ebd10d1366a71000409e62
https://doi.org/10.1016/j.neulet.2007.03.024
https://doi.org/10.1016/j.neulet.2007.03.024
Autor:
Carolina Perez-Pastene, Pedro Martinez-Alvarado, Irmgard Paris, Claudio Olea-Azar, Patricia Castañeda, Maria Jose Sanchez de las Matas, Juan Segura-Aguilar, Pablo Caviedes, Sergio Cardenas, Eduardo Couve, Christian Arriagada, Rebecca Graumann, Maria T Herrero
Publikováno v:
NEUROBIOLOGY OF DISEASE
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Neurobiology of Disease, Vol 16, Iss 2, Pp 468-477 (2004)
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Neurobiology of Disease, Vol 16, Iss 2, Pp 468-477 (2004)
Leukoaminochrome o-semiquinone radical is generated during one-electron reduction of dopamine oxidation product aminochrome when DT-diaphorase is inhibited. Incubation of 100 microM aminochrome with 100 microM dicoumarol, an inhibitor of DT-diaphoras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d563a15df5b0a357a5a02eb949bb5482
https://doi.org/10.1016/j.nbd.2004.03.014
https://doi.org/10.1016/j.nbd.2004.03.014
Autor:
Rodrigo Avello, Greggory J. Wilhoite, Luis Torres, Oscar Acosta, Federico Micheli, Juan Segura-Aguilar, Fernando Díaz-Grez, Olimpio Ortega, Owen A. Ross, Dora Yearout, Carlos Cosentino, Claudia Perandones, Mario Cornejo-Olivas, Victoria Alvarez, Matthew J. Farrer, Marcelo Miranda, Pilar Mazzetti, Luis Lay-Son, Ignacio F. Mata, Carles Vilariño-Güell, Osvaldo Trujillo-Godoy, Victoria Marca, Angel C. Medina, Elena Dieguez, Pablo Venegas, Víctor Raggio, Cyrus P. Zabetian, Carolina Perez-Pastene, Justin A. Bacon
Publikováno v:
PARKINSONISM & RELATED DISORDERS
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Mutations in the LRRK2 gene are the most common genetic cause of Parkinson’s disease, with frequencies displaying a high degree of population-specificity. Although more than 100 coding substitutions have been identified, only seven have been proven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7dea87fa5b6ea62b6b5e84465cc332
https://pubmed.ncbi.nlm.nih.gov/21632271
https://pubmed.ncbi.nlm.nih.gov/21632271
Autor:
Susan P. LeDoux, Juan Segura-Aguilar, Pablo Caviedes, Irmgard Paris, Carolina Perez-Pastene, Eduardo Couve
Publikováno v:
The Journal of biological chemistry. 284(20)
Parkinsonism is one of the major neurological symptoms in Wilson disease, and young workers who worked in the copper smelting industry also developed Parkinsonism. We have reported the specific neurotoxic action of copper·dopamine complex in neurons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31e251da280bf3f5b4b3ee934e666d3
https://pubmed.ncbi.nlm.nih.gov/19265190
https://pubmed.ncbi.nlm.nih.gov/19265190
Autor:
Irmgard, Paris, Pedro, Martinez-Alvarado, Carolina, Perez-Pastene, Marcelo N N, Vieira, Claudio, Olea-Azar, Rita, Raisman-Vozari, Sergio, Cardenas, Rebeca, Graumann, Pablo, Caviedes, Juan, Segura-Aguilar
Publikováno v:
Journal of neurochemistry. 92(5)
The role of dopamine in iron uptake into catecholaminergic neurons, and dopamine oxidation to aminochrome and its one-electron reduction in iron-mediated neurotoxicity, was studied in RCSN-3 cells, which express both tyrosine hydroxylase and monoamin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8fb48928e4fcd64fa3d37b89d15ddf20
https://pubmed.ncbi.nlm.nih.gov/15715653
https://pubmed.ncbi.nlm.nih.gov/15715653
Autor:
Patricio Fuentes, Juan Segura-Aguilar, Claudio Olea-Azar, Sergio Cardenas, Pedro Martinez-Alvarado, Rebecca Graumann, Pablo Caviedes, Carolina Perez-Pastene, Irmgard Paris
Publikováno v:
CHEMICAL RESEARCH IN TOXICOLOGY
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
We report a new and specific mechanism for iron-mediated neurotoxicity using RCHT cells, which were derived from rat hypothalamus. RCHT cells exhibit immunofluorescent-positive markers for dopamine beta-hydroxylase and the norepinephrine transporter,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703f75f48c1459208d29f6d19f2a629b
