In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design

Autor: William F. Porto, Luz Irazazabal, Eliane S. F. Alves, Suzana M. Ribeiro, Carolina O. Matos, Állan S. Pires, Isabel C. M. Fensterseifer, Vivian J. Miranda, Evan F. Haney, Vincent Humblot, Marcelo D. T. Torres, Robert E. W. Hancock, Luciano M. Liao, Ali Ladram, Timothy K. Lu, Cesar de la Fuente-Nunez, Octavio L. Franco

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

Antimicrobial peptides are considered promising alternatives to antibiotics. Here the authors developed a computational algorithm that starts with peptides naturally occurring in plants and optimizes this starting material to yield new variants which

Externí odkaz: https://doaj.org/article/9fc4525fbb254412958fded74332d577

Synthesis and in silico and in vitro evaluation of trimethoxy-benzamides designed as anti-prion derivatives

Autor: Carolina F. Goes, Maria Claudia Barbosa, Lucas M. Ascari, Anderson S. Pinheiro, Yraima Cordeiro, Raissa Alves da Conceição, Rodolfo C. Maia, Carolina O. Matos, Natália Ferreira, Marina Amaral Alves, Alessandra Mendonça Teles de Souza, Byron Caughey

Publikováno v: Medicinal Chemistry Research. 28:2128-2141

Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are neurodegenerative disorders which affect mammals, including the human species, and arise after the conversion of the monomeric cellular prion protein (PrPC) into the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15d4aa07930b7416e725b0d1115b9d56
https://doi.org/10.1007/s00044-019-02441-2

NMR structures and molecular dynamics simulation of hylin‐a1 peptide analogs interacting with micelles

Autor: Eduardo Maffud Cilli, Luciano M. Lião, Amanda Souza Câmara, Edson Crusca, Carolina O. Matos, Aline L. de Oliveira, Reinaldo Marchetto

Publikováno v: Journal of Peptide Science. 23:421-430

Antimicrobial peptides are recognized candidates with pharmaceutical potential against epidemic emerging multi-drug resistant bacteria. In this study, we use nuclear magnetic resonance spectroscopy and molecular dynamics simulations to determine the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f408459c68c9ebe4a45bd3226c474ca
https://doi.org/10.1002/psc.3002

Fast and potent bactericidal membrane lytic activity of PaDBS1R1, a novel cationic antimicrobial peptide

Autor: William F. Porto, Isabel C. M. Fensterseifer, Vincent Humblot, Luz N. Irazazabal, Octavio L. Franco, Sónia Gonçalves, Eliane S. F. Alves, Carolina O. Matos, Suzana M. Ribeiro, Antônio Carlos Severo Menezes, Luciano M. Lião, Mário R. Felício, Ali Ladram, Nuno C. Santos

Publikováno v: Biochimica et Biophysica Acta:Biomembranes
Biochimica et Biophysica Acta:Biomembranes, Elsevier, 2019, 1861 (1), pp.178-190. ⟨10.1016/j.bbamem.2018.08.001⟩
Biochimica et Biophysica Acta:Biomembranes, 2019, 1861 (1), pp.178-190. ⟨10.1016/j.bbamem.2018.08.001⟩
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
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Biochimica et Biophysica Acta (BBA)-Biomembranes

© 2018 Elsevier B.V. All rights reserved.
Antimicrobial peptides (AMPs) are promising candidates for the development of future antibiotics. In an attempt to increase the efficacy of therapeutic AMPs, computer-based design methods appear as a re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d485b7910f38d20e83372d4bcfe69dc
https://hal.sorbonne-universite.fr/hal-02053758/document

In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design

Autor: Eliane S. F. Alves, Luciano M. Lião, Cesar de la Fuente-Nunez, Vívian de Jesus Miranda, William F. Porto, Isabel C. M. Fensterseifer, Robert E. W. Hancock, Állan S. Pires, Vincent Humblot, Evan F. Haney, Timothy K. Lu, Suzana M. Ribeiro, Carolina O. Matos, Marcelo D. T. Torres, Octavio L. Franco, Luz N. Irazazabal, Ali Ladram

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), ⟨10.1038/s41467-018-03746-3⟩
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications, 2018, 9 (1), ⟨10.1038/s41467-018-03746-3⟩

Plants are extensively used in traditional medicine, and several plant antimicrobial peptides have been described as potential alternatives to conventional antibiotics. However, after more than four decades of research no plant antimicrobial peptide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792ce8a45f1fbabd2db7eeae05c1df8a
https://hal.archives-ouvertes.fr/hal-01767730