Výsledky vyhledávání - "Carolina Martinez‐Ciarpaglini"

Akademický článek

Mapping the complexity and diversity of tertiary lymphoid structures in primary and peritoneal metastatic gastric cancer

Autor: Carolina Martinez-Ciarpaglini, Daniela S Thommen, Nicole C T van Grieken, Joep Grootjans, Sarah Derks, Tessa S Groen-van Schooten, Rosalia Franco Fernandez, Emma N Bos, Jens Seidel, Job Saris, Tania C Fleitas

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)

Background Tertiary lymphoid structures (TLSs) are thought to stimulate antitumor immunity and positively impact prognosis and response to immune checkpoint blockade. In gastric cancers (GCs), however, TLSs are predominantly found in GC with poor pro

Externí odkaz: https://doaj.org/article/785d4f4c841145b58d42944ccbc30db0

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Akademický článek

Long-term platinum-based drug accumulation in cancer-associated fibroblasts promotes colorectal cancer progression and resistance to therapy

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

Standard platinum-based chemotherapy is the basis of treatment of many cancers, however a proportion of patients do not derive benefit. Here the authors show that the platinum-based drug oxaliplatin accumulates in cancer-associated fibroblasts, activ

Externí odkaz: https://doaj.org/article/6c73f8461c124a2ba8d43e933f393b91

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Akademický článek

'Proteotranscriptomic analysis of advanced colorectal cancer patient derived organoids for drug sensitivity prediction'

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-22 (2023)

Abstract Background Patient-derived organoids (PDOs) from advanced colorectal cancer (CRC) patients could be a key platform to predict drug response and discover new biomarkers. We aimed to integrate PDO drug response with multi-omics characterizatio

Externí odkaz: https://doaj.org/article/a72cfc5ee59741f4839fb4407bd9b3b0

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Akademický článek

Molecular profile in Paraguayan colorectal cancer patients, towards to a precision medicine strategy

Publikováno v: Cancer Medicine, Vol 8, Iss 6, Pp 3120-3130 (2019)

Abstract Somatic mutation analysis and evaluation of microsatellite instability (MSI) have become mandatory for selecting personalized therapy strategies for advanced colorectal cancer and are not available as routine methods in Paraguay. The aims of

Externí odkaz: https://doaj.org/article/c4ab06011a3946a985a944f3fdd2eacb

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Akademický článek

Detection of postoperative plasma circulating tumour DNA and lack of CDX2 expression as markers of recurrence in patients with localised colon cancer

Publikováno v: ESMO Open, Vol 5, Iss 5 (2020)

Background Colon cancer (CC) is a heterogeneous disease. Novel prognostic factors beyond pathological staging are required to accurately identify patients at higher risk of relapse. Integrating these new biological factors, such as plasma circulating

Externí odkaz: https://doaj.org/article/1ba9bbd5d5ea42709d18d95be914965b

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Akademický článek

Assessing molecular subtypes of gastric cancer: microsatellite unstable and Epstein-Barr virus subtypes. Methods for detection and clinical and pathological implications

Autor: Valentina Gambardella, Andrés Cervantes, Carolina Martinez-Ciarpaglini, Tania Fleitas-Kanonnikoff, Marta Llorca, Cristina Mongort, Regina Mengual, Gema Nieto, Lara Navarro, Marisol Huerta, Susana Rosello, Desamparados Roda, Samuel Navarro, Gloria Ribas

Publikováno v: ESMO Open, Vol 4, Iss 3 (2019)

Background The molecular classification of gastric cancer recognises two subtypes prone to immune checkpoint blockade: the microsatellite unstable and the Epstein-Barr virus (EBV)-related tumours. We aim to assess the concordance between immunohistoc

Externí odkaz: https://doaj.org/article/55466a2d21174801b8184ccba03bab4c

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Data from NRF2 through RPS6 Activation Is Related to Anti-HER2 Drug Resistance in HER2-Amplified Gastric Cancer

Autor: Andrés Cervantes, Josefa Castillo, Susana Roselló, Marisol Huerta, Juan Miguel Cejalvo, Pablo Tolosa, Tania Fleitas, Desamparados Roda, Carolina Martinez Ciarpaglini, Noelia Tarazona, Francisco Gimeno-Valiente, Valentina Gambardella

Purpose:Despite the clinical advantage of the combination of trastuzumab and platinum-based chemotherapy in HER2-amplified tumors, resistance will eventually develop. The identification of molecular mechanisms related to primary and acquired resistan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb24318b432c5549dbd90e52dd22da8
https://doi.org/10.1158/1078-0432.c.6527910

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NRF2 through RPS6 Activation Is Related to Anti-HER2 Drug Resistance in HER2-Amplified Gastric Cancer

Autor: Carolina Martinez Ciarpaglini, F. Gimeno-Valiente, Valentina Gambardella, Josefa Castillo, Desamparados Roda, Andrés Cervantes, Susana Roselló, P. Tolosa, Juan Miguel Cejalvo, Marisol Huerta, Noelia Tarazona, T. Fleitas

Publikováno v: Clinical Cancer Research. 25:1639-1649

Purpose: Despite the clinical advantage of the combination of trastuzumab and platinum-based chemotherapy in HER2-amplified tumors, resistance will eventually develop. The identification of molecular mechanisms related to primary and acquired resista

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c3501214b5528839924a3ead380d9aa
https://doi.org/10.1158/1078-0432.ccr-18-2421

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