Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Carolina Makowski"'
Autor:
Hao Wang, Carolina Makowski, Yanxiao Zhang, Anna Qi, Tobias Kaufmann, Olav B. Smeland, Mark Fiecas, Jian Yang, Peter M. Visscher, Chi-Hua Chen
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112896- (2023)
Summary: The impact of chromosomal inversions on human brain morphology remains underexplored. We studied 35 common inversions classified from genotypes of 33,018 adults with European ancestry. The inversions at 2p22.3, 16p11.2, and 17q21.31 reach ge
Externí odkaz:
https://doaj.org/article/49a737db4c2d4eadac090dcf494e573c
Autor:
Chun Chieh Fan, Robert Loughnan, Carolina Makowski, Diliana Pecheva, Chi-Hua Chen, Donald J. Hagler, Wesley K. Thompson, Nadine Parker, Dennis van der Meer, Oleksandr Frei, Ole A. Andreassen, Anders M. Dale
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
How the tissue composition of the human brain is determined remains unclear. Here, the authors apply advanced analyses to two large imaging genetic datasets to identify and validate genetic loci that simultaneously influence multiple brain regions.
Externí odkaz:
https://doaj.org/article/4e03d88fd08c40ea9a031f33f0f463ab
Autor:
Synthia Guimond, Suraj S. Mothi, Carolina Makowski, M. Mallar Chakravarty, Matcheri S. Keshavan
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Relatives of individuals with schizophrenia have a higher risk of developing the illness compared to the general population. Thus, youth at familial high risk (FHR) offer a unique opportunity to identify neuroimaging-based endophenotypes of
Externí odkaz:
https://doaj.org/article/7c6122f12b044a2882916921c9af4f36
Autor:
Weiqi Zhao, Carolina Makowski, Donald J. Hagler, Hugh P. Garavan, Wesley K. Thompson, Deanna J. Greene, Terry L. Jernigan, Anders M. Dale
Publikováno v:
NeuroImage, Vol 270, Iss , Pp 119946- (2023)
Characterizing the optimal fMRI paradigms for detecting behaviorally relevant functional connectivity (FC) patterns is a critical step to furthering our knowledge of the neural basis of behavior. Previous studies suggested that FC patterns derived fr
Externí odkaz:
https://doaj.org/article/e1a31013d7da4b9ba7a0d6c9e5751582
Autor:
Robert J. Loughnan, Alexey A. Shadrin, Oleksandr Frei, Dennis van der Meer, Weiqi Zhao, Clare E. Palmer, Wesley K. Thompson, Carolina Makowski, Terry L. Jernigan, Ole A. Andreassen, Chun Chieh Fan, Anders M. Dale
Publikováno v:
NeuroImage, Vol 263, Iss , Pp 119632- (2022)
Genome-Wide Association studies have typically been limited to univariate analysis in which a single outcome measure is tested against millions of variants. Recent work demonstrates that a Multivariate Omnibus Statistic Test (MOSTest) is well powered
Externí odkaz:
https://doaj.org/article/8dacec5e225a4a2cacafea5ac3c0f6d5
Autor:
Alexey A. Shadrin, Tobias Kaufmann, Dennis van der Meer, Clare E. Palmer, Carolina Makowski, Robert Loughnan, Terry L. Jernigan, Tyler M. Seibert, Donald J Hagler, Olav B. Smeland, Ehsan Motazedi, Yunhan Chu, Aihua Lin, Weiqiu Cheng, Guy Hindley, Wesley K. Thompson, Chun C. Fan, Dominic Holland, Lars T. Westlye, Oleksandr Frei, Ole A. Andreassen, Anders M. Dale
Publikováno v:
NeuroImage, Vol 244, Iss , Pp 118603- (2021)
Brain morphology has been shown to be highly heritable, yet only a small portion of the heritability is explained by the genetic variants discovered so far. Here we extended the Multivariate Omnibus Statistical Test (MOSTest) and applied it to genome
Externí odkaz:
https://doaj.org/article/00840c2b0f414737b79b926d62cb639e
Autor:
Hao Wang, Min-Tzu Lo, Sara Brin Rosenthal, Carolina Makowski, Ole A. Andreassen, Rany M. Salem, Linda K. McEvoy, Mark Fiecas, Chi-Hua Chen
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Sex differences have been observed in the clinical manifestations of Alzheimer’s disease (AD) and elucidating their genetic basis is an active research topic. Based on autosomal genotype data of 7,216 men and 10,680 women, including 8,136 AD cases
Externí odkaz:
https://doaj.org/article/0d2d36e5fa174695b7eedae01d615dd1
Autor:
Hao Wang, Brin Sara Rosenthal, Carolina Makowski, Min‐Tzu Lo, Ole A. Andreassen, Rany M. Salem, Linda K. McEvoy, Mark Fiecas, Chi‐Hua Chen
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 13, Iss 1, Pp n/a-n/a (2021)
Abstract Introduction Sex‐dependent risk factors may underlie sex differences in Alzheimer's disease (AD). Methods Using sex‐stratified genome‐wide association studies (GWAS) of AD, we evaluated associations of 12 traits with AD through polygen
Externí odkaz:
https://doaj.org/article/62aebdb3f59b44c19bb4907bd8960c2f
Autor:
Samir Das, Xavier Lecours Boucher, Christine Rogers, Carolina Makowski, François Chouinard-Decorte, Kathleen Oros Klein, Natacha Beck, Pierre Rioux, Shawn T. Brown, Zia Mohaddes, Cole Zweber, Victoria Foing, Marie Forest, Kieran J. O’Donnell, Joanne Clark, Michael J. Meaney, Celia M. T. Greenwood, Alan C. Evans
Publikováno v:
Frontiers in Neuroinformatics, Vol 12 (2018)
Analysis of “omics” data is often a long and segmented process, encompassing multiple stages from initial data collection to processing, quality control and visualization. The cross-modal nature of recent genomic analyses renders this process cha
Externí odkaz:
https://doaj.org/article/684c4f7799bf45f0aad9a3ec40cf1f76
Autor:
Michael Bodnar, Ashok K. Malla, Carolina Makowski, M. Mallar Chakravarty, Ridha Joober, Martin Lepage
Publikováno v:
BJPsych Open, Vol 2, Pp 139-146 (2016)
BackgroundCurrent neuroscience literature has related treatment with aripiprazole to improved memory performance and subcellular changes in the hippocampus.AimsTo explore the volumetric changes in hippocampal grey matter in people with a first episod
Externí odkaz:
https://doaj.org/article/b8868a795f2444f8b184b82db01a0037