Liver-specific overexpression of HKDC1 increases hepatocyte size and proliferative capacity

Autor: Carolina M. Pusec, Vladimir Ilievski, Adam De Jesus, Zeenat Farooq, Joseph L. Zapater, Nadia Sweis, Hagar Ismail, Md Wasim Khan, Hossein Ardehali, Jose Cordoba-Chacon, Brian T. Layden

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)

Abstract A primary role of the liver is to regulate whole body glucose homeostasis. Glucokinase (GCK) is the main hexokinase (HK) expressed in hepatocytes and functions to phosphorylate the glucose that enters via GLUT transporters to become glucose-

Externí odkaz: https://doaj.org/article/071b50d72cdc40519a71ce57d0f855c6

Hepatocyte-Specific Loss of PPARγ Protects Mice From NASH and Increases the Therapeutic Effects of Rosiglitazone in the LiverSummary

Autor: Samuel M. Lee, Carolina M. Pusec, Gregory H. Norris, Adam De Jesus, Alberto Diaz-Ruiz, Jose Muratalla, Andre Sarmento-Cabral, Grace Guzman, Brian T. Layden, Jose Cordoba-Chacon

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1291-1311 (2021)

Background & Aims: Nonalcoholic steatohepatitis (NASH) is commonly observed in patients with type 2 diabetes, and thiazolidinediones (TZD) are considered a potential therapy for NASH. Although TZD increase insulin sensitivity and partially reduce ste

Externí odkaz: https://doaj.org/article/f5c89553ae6f4961a45e0c8514ac9991

Hepatocyte-Specific Loss of PPARγ Protects Mice From NASH and Increases the Therapeutic Effects of Rosiglitazone in the Liver

Autor: Brian T. Layden, Samuel M Lee, Carolina M. Pusec, Andre Sarmento-Cabral, Grace Guzman, Jose Muratalla, Jose Cordoba-Chacon, Alberto Diaz-Ruiz, Gregory H Norris, Adam De Jesus

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1291-1311 (2021)

Background & Aims Nonalcoholic steatohepatitis (NASH) is commonly observed in patients with type 2 diabetes, and thiazolidinediones (TZD) are considered a potential therapy for NASH. Although TZD increase insulin sensitivity and partially reduce stea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d64e6962687742a800c78603d9395653
https://doi.org/10.1016/j.jcmgh.2021.01.003

Hexokinase 1 cellular localization regulates the metabolic fate of glucose

Autor: Hossein Ardehali, Justin Geier, Trenton Nicioli, Joshua S. Stoolman, Krishna V. Suresh, Samuel E. Weinberg, Lauren Goodman, Adam De Jesus, Kai Xu, Hsiang-Chun Chang, Paulina J Stanczyk, Chunlei Chen, Navdeep S. Chandel, Carolina M. Pusec, Arianne E. Rodriguez, Brian T. Layden, Issam Ben-Sahra, Jason S. Shapiro, Yihan Chen, Kriti P. Shah, Farnaz Keyhani-Nejad

Publikováno v: Molecular Cell. 82:1261-1277.e9

The product of hexokinase (HK) enzymes, glucose-6-phosphate, can be metabolized through glycolysis or directed to alternative pathways, such as the pentose phosphate pathway (PPP) to generate anabolic intermediates. However, it is not known what dete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167b7e76ba820281c52391093f914069
https://doi.org/10.1016/j.molcel.2022.02.028

HKDC1 Is a Novel Hexokinase Involved in Whole-Body Glucose Use

Autor: William L. Lowe, Brian T. Layden, Anthony R. Angueira, Medha Priyadarshini, Timothy E. Reddy, Xianzhong Ding, Guang Yu Yang, Amy C. Y. Lo, Cong Guo, Korri S. Hershenhouse, Anton E. Ludvik, Carolina M. Pusec

Publikováno v: Endocrinology. 157:3452-3461

In a recent genome-wide association study, hexokinase domain-containing protein 1, or HKDC1, was found to be associated with gestational glucose levels during 2-hour glucose tolerance tests at 28 weeks of pregnancy. Because our understanding of the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb120f7d5fc787cdb172973b3c62f93
https://doi.org/10.1210/en.2016-1288