Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Carolina M C Catta-Preta"'
Autor:
John W Davey, Carolina M C Catta-Preta, Sally James, Sarah Forrester, Maria Cristina M Motta, Peter D Ashton, Jeremy C Mottram
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 1 (2021)
Abstract Angomonas deaneiA. deanei
Externí odkaz:
https://doaj.org/article/d26c17a59ea443559c26db3fd0fb617f
Autor:
Andreas Damianou, Rebecca J Burge, Carolina M C Catta-Preta, Vincent Geoghegan, Y Romina Nievas, Katherine Newling, Elaine Brown, Richard Burchmore, Boris Rodenko, Jeremy C Mottram
Publikováno v:
PLoS Pathogens, Vol 16, Iss 6, p e1008455 (2020)
The parasitic protozoan Leishmania requires proteasomal, autophagic and lysosomal proteolytic pathways to enact the extensive cellular remodelling that occurs during its life cycle. The proteasome is essential for parasite proliferation, yet little i
Externí odkaz:
https://doaj.org/article/8acf2f02f6934275a61fe7224766006e
A Target Engagement Assay to Assess Uptake, Potency, and Retention of Antibiotics in Living Bacteria
Autor:
Rebeka C. Fanti, Stanley N. S. Vasconcelos, Carolina M. C. Catta-Preta, Jaryd R. Sullivan, Gustavo P. Riboldi, Caio V. dos Reis, Priscila Z. Ramos, Aled M. Edwards, Marcel A. Behr, Rafael M. Couñago
Publikováno v:
ACS infectious diseases. 8(8)
New antibiotics are urgently needed to counter the emergence of antimicrobial-resistant pathogenic bacteria. A major challenge in antibiotic drug discovery is to turn potent biochemical inhibitors of essential bacterial components into effective anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1abbcf03e5ead58f2c872b3ad5a761
https://pubmed.ncbi.nlm.nih.gov/35815896
https://pubmed.ncbi.nlm.nih.gov/35815896
Autor:
Carolina M. C. Catta-Preta, Rishi Rajesh, Fernando Altamura, Igor Cestari, Nilmar Silvio Moretti
Publikováno v:
Drug Development Research. 83:225-252
Human trypanosomiasis and leishmaniasis are vector-borne neglected tropical diseases caused by infection with the protozoan parasites Trypanosoma spp. and Leishmania spp., respectively. Once restricted to endemic areas, these diseases are now distrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1012691a95cd732ca141dc3da509f7b0
https://doi.org/10.1002/ddr.21664
https://doi.org/10.1002/ddr.21664
Autor:
Rachel Neish, Juliana B.T. Carnielli, Pegine B. Walrad, Eliza V. C. Alves-Ferreira, Katherine Newling, Charlotte S. Hughes, Barbora Vojtkova, Vincent Geohegan, Petr Volf, Carolina M. C. Catta-Preta, Jeremy C. Mottram, Andrei Mihut, Ben Powell, Laurence G. Wilson, Nicola Baker, Jovana Sadlova, Jon W. Pitchford, Jayanthi Anand
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Differentiation between distinct stages is fundamental for the life cycle of intracellular protozoan parasites and for transmission between hosts, requiring stringent spatial and temporal regulation. Here, we apply kinome-wide gene deletion and gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af62b9a87e93b08006a97fc90ba95dd6
https://doi.org/10.1038/s41467-021-21360-8
https://doi.org/10.1038/s41467-021-21360-8
Autor:
William J. Zuercher, Christopher G. Langendorf, Rafael M. Couñago, Chenchu Lin, Alfredo Picado, Mohammad Anwar Hossain, Jonathan S. Oakhill, Dominik Awad, Joseph R. Pilotte, David H. Drewry, Carolina M. C. Catta-Preta, Daniel E. Frigo, Carrow I. Wells, P.Z. Ramos, Christopher R. M. Asquith, Sean N. O’Byrne, Timothy M. Willson, Louisa Temme, A.S. Santiago, Kevin Nay, Thomas L. Pulliam, John W. Scott, Yi Liang, Benjamin J. Eduful
Publikováno v:
Journal of Medicinal Chemistry
CAMKK2 is a serine/threonine kinase and an activator of AMPK whose dysregulation is linked with multiple diseases. Unfortunately, STO-609, the tool inhibitor commonly used to probe CAMKK2 signaling, has limitations. To identify promising scaffolds as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dbcff8ed683ad253b52fbd8a7704dcb
https://acuresearchbank.acu.edu.au/item/8x148/hinge-binder-scaffold-hopping-identifies-potent-calcium-calmodulin-dependent-protein-kinase-kinase-2-camkk2-inhibitor-chemotypes
https://acuresearchbank.acu.edu.au/item/8x148/hinge-binder-scaffold-hopping-identifies-potent-calcium-calmodulin-dependent-protein-kinase-kinase-2-camkk2-inhibitor-chemotypes
Autor:
Chenchu Lin, David H. Drewry, Carrow I. Wells, Joseph R. Pilotte, John W. Scott, Benjamin J. Eduful, Yi Liang, Rafael M. Couñago, Carolina M. C. Catta-Preta, Alfredo Picado, Sean N. O’Byrne, Jonathan S. Oakhill, Dominik Awad, Christopher G. Langendorf, Christopher R. M. Asquith, Timothy M. Willson, Thomas L. Pulliam, Louisa Temme, Daniel E. Frigo, William J. Zuercher, P.Z. Ramos, A.S. Santiago, Kevin Nay
CAMKK2 is a serine/threonine kinase and an activator of AMPK whose dysregulation is linked with multiple diseases. Unfortunately, STO-609, the tool inhibitor commonly used to probe CAMKK2 signaling, has limitations. To identify promising scaffolds as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103f4b3c66ec89afbef05608bfa9d132
https://doi.org/10.26434/chemrxiv.13484763
https://doi.org/10.26434/chemrxiv.13484763
Autor:
Jeremy C. Mottram, John W. Davey, Maria Cristina M. Motta, Sally James, Carolina M. C. Catta-Preta, Sarah Forrester, Peter D. Ashton
Publikováno v:
G3: Genes|Genomes|Genetics
G3: Genes, Genomes, Genetics, Vol 11, Iss 1 (2021)
G3: Genes, Genomes, Genetics, Vol 11, Iss 1 (2021)
Angomonas deanei is an endosymbiont-bearing trypanosomatid with several highly fragmented genome assemblies and unknown chromosome number. We present an assembly of the A. deanei nuclear genome based on Oxford Nanopore sequence that resolves into 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f6eaf759b18d20933789bfe918acffd
https://pubmed.ncbi.nlm.nih.gov/33561222
https://pubmed.ncbi.nlm.nih.gov/33561222
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2116
In this chapter we describe different electron microscopy techniques such as freeze fracture, deep etching, and three-dimensional reconstruction, obtained by electron tomography or focused ion beam scanning electron microscopy (FIB-SEM), combined wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::05690a87b7c91ebd402013a845d7fa2e
https://pubmed.ncbi.nlm.nih.gov/32221935
https://pubmed.ncbi.nlm.nih.gov/32221935
Autor:
Katerina Pruzinova, Flavia Moreira-Leite, Jack D. Sunter, Jitka Myskova, Clare Halliday, Ryuji Yanase, Jeremy C. Mottram, Carolina M. C. Catta-Preta, Petr Volf
The shape and form of the flagellated eukaryotic parasiteLeishmaniais sculpted to its ecological niches and needs to be transmitted to each generation with great fidelity. The shape of theLeishmaniacell is defined by the sub-pellicular microtubule ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f9a182006f4ec7ece7f2c1c5d9c9ef9
https://doi.org/10.1101/2020.03.26.009928
https://doi.org/10.1101/2020.03.26.009928