Zobrazeno 1 - 10 of 60 pro vyhledávání: '"Carolina J. Jorgez"'
1
Loss of WNT4 in the gubernaculum causes unilateral cryptorchidism and fertility defects
Autor: Abhishek Seth, Juan C. Bournat, Olga Medina-Martinez, Armando Rivera, Joshua Moore, Hunter Flores, Jill A. Rosenfeld, Liya Hu, Carolina J. Jorgez
Publikováno v: Development (Cambridge, England). 149(23)
Undescended testis (UDT) affects 6% of male births. Despite surgical correction, some men with unilateral UDT may experience infertility with the contralateral descended testis (CDT) showing no A-dark spermatogonia. To improve our understanding of th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d62cf4f93bf5fb399571495ef537eea3
https://pubmed.ncbi.nlm.nih.gov/36448532
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2
Variants inALX4and their association with genitourinary defects
Autor: Juan C. Bournat, Jill A. Rosenfeld, Nathan Wilken, Carolina J. Jorgez, Ching H. Chen, Jason Zhang, Abhishek Seth
Publikováno v: Andrology
Background Genitourinary anomalies occur in approximately 1% of humans, but in most cases, the cause is unknown. Aristaless-like homeobox 4 (ALX4) is an important homeodomain transcription factor. ALX4 mutations in humans and mouse have been associat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ddace2e0d80b915748a9ca8dc0af797
https://doi.org/10.1111/andr.12815
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4
Hypospadias risk is increased with maternal residential exposure to hormonally active hazardous air pollutants
Autor: Kunj R. Sheth, Michael E. Scheurer, Carolina J. Jorgez, Erin C. Peckham-Gregory, Abhishek Seth, Tiffany M. Chambers, Marisol O'Neill, Erin Kovar, Jeffrey T. White, Philip J. Lupo, Peter H. Langlois
Publikováno v: Birth Defects Research. 111:345-352
BACKGROUND: With the increasing birth prevalence of hypospadias, there is growing concern for pollutant exposure interfering with normal penile development. We assess the association between hypospadias and hormonally active hazardous air pollutants
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffdc9e8b56715d462bb922971437b255
https://doi.org/10.1002/bdr2.1461
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5
Evaluating Outcomes of Differential Surgical Management of Nonfunctioning Upper Pole Renal Moieties in Duplex Collecting Systems
Autor: Chester J. Koh, Paul F. Austin, Kunj R. Sheth, Abhishek Seth, Ming Hsien Wang, Duong D. Tu, Carolina J. Jorgez, Nicolette K. Janzen, Angela G. Mittal, Jeffrey T. White, Edmond T. Gonzales, David R. Roth
Publikováno v: Urology. 123:198-203
Objective To evaluate the management and clinical outcomes of nonfunctioning upper pole moieties treated with either upper pole heminephrectomy or upper pole preservation with lower ureteral reconstruction at a single tertiary institution. Methods Af
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac847f4ecc205b3cbbd8b7429c026df
https://doi.org/10.1016/j.urology.2018.06.028
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6
Akademický článek
Genitourinary defects associated with genomic deletions in 2p15 encompassing OTX1.
Autor: Carolina J Jorgez, Jill A Rosenfeld, Nathan R Wilken, Hima V Vangapandu, Aysegul Sahin, Dung Pham, Claudia M B Carvalho, Anne Bandholz, Amanda Miller, David D Weaver, Barbara Burton, Deepti Babu, John S Bamforth, Timothy Wilks, Daniel P Flynn, Elizabeth Roeder, Ankita Patel, Sau W Cheung, James R Lupski, Dolores J Lamb
Publikováno v: PLoS ONE, Vol 9, Iss 9, p e107028 (2014)
Normal development of the genitourinary (GU) tract is a complex process that frequently goes awry. In male children the most frequent congenital GU anomalies are cryptorchidism (1-4%), hypospadias (1%) and micropenis (0.35%). Bladder exstrophy and ep
Externí odkaz: https://doaj.org/article/a6dba8ad6ada4ea8815da5d64033dc6b
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7
PRSS50 is a testis protease responsible for proper sperm tail formation and function
Autor: Nathan Wilken, Armando Rivera, Adam T. Szafran, Joshua Moore, Abhishek Seth, Ching H. Chen, Jason M. Scovell, Minerva Solis, Jason Zhang, Juan C. Bournat, Carolina J. Jorgez
Publikováno v: Development
Multiple morphological abnormalities of the sperm flagella (MMAF) are a major cause of asthenoteratozoospermia. We have identified protease serine 50 (PRSS50) as having a crucial role in sperm development, because Prss50-null mice presented with impa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e14571745f8fd6b1d601a3e66f6af0
https://pubmed.ncbi.nlm.nih.gov/33913480
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8
E2F1 regulates testicular descent and controls spermatogenesis by influencing WNT4 signaling
Autor: Ching H. Chen, Carolina J. Jorgez, Abhishek Seth, Dolores J. Lamb, Juan C. Bournat, Nathan Wilken
Publikováno v: Development
Cryptorchidism is the most common urologic birth defect in men and is a predisposing factor of male infertility and testicular cancer, yet the etiology remains largely unknown. E2F1 microdeletions and microduplications contribute to cryptorchidism, i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::851927ece422f494777b32fb539f63c9
https://pubmed.ncbi.nlm.nih.gov/33441379
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9
Maternal hypertension and hypospadias in offspring: A systematic review and meta-analysis
Autor: Fatima R. Sheriff, A. J. Agopian, Carolina J. Jorgez, Abhishek Seth, Philip J. Lupo, Adriana Lopez
Publikováno v: Birth Defects Research. 111:9-15
Background Several studies have reported an association between maternal hypertensive disorders and hypospadias in offspring; however there is still debate on the role of maternal hypertension and preeclampsia on this relatively common congenital mal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db4fb6979f8d92c9585b55e442925adf
https://doi.org/10.1002/bdr2.1415
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