Zobrazeno 1 - 10 of 31 pro vyhledávání: '"Carolina Ines Domaica"'
1
Tumor-Experienced Human NK Cells Express High Levels of PD-L1 and Inhibit CD8+ T Cell Proliferation
Autor: Aldana Trotta, Andrea Ziblat, Gonzalo Vitagliano, Mercedes Beatriz Fuertes, M. Cecilia Santilli, Adrián Friedrich, Carolina Ines Domaica, Carlos Ameri, Mariana Gantov, Hernando Rios Pita, Luis Rico, Sol Yanel Nuñez, Nicolás Richards, Agustin Rovegno, Jessica Mariel Sierra, María Victoria Regge, Florencia Secchiari, Ximena Lucía Raffo Iraolagoitia, Norberto Walter Zwirner, Nicolás Torres
Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Frontiers in Immunology, Vol 12 (2021)
Natural Killer (NK) cells play a key role in cancer immunosurveillance. However, NK cells from cancer patients display an altered phenotype and impaired effector functions. In addition, evidence of a regulatory role for NK cells is emerging in divers
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8860c35d8ade243f41c695f97f09659
https://doi.org/10.3389/fimmu.2021.745939
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2
Leveraging NKG2D Ligands in Immuno-Oncology
Autor: Norberto Walter Zwirner, Mercedes Beatriz Fuertes, Carolina Ines Domaica
Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Immune checkpoint inhibitors (ICI) revolutionized the field of immuno-oncology and opened new avenues towards the development of novel assets to achieve durable immune control of cancer. Yet, the presence of tumor immune evasion mechanisms represents
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d79da142c76e1e4721742c07a7d4d8
https://doi.org/10.3389/fimmu.2021.713158
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3
Circulating and Tumor-Infiltrating NK Cells From Clear Cell Renal Cell Carcinoma Patients Exhibit a Predominantly Inhibitory Phenotype Characterized by Overexpression of CD85j, CD45, CD48 and PD-1
Autor: Agustin Rovegno, Norberto Walter Zwirner, Nicolás Torres, Florencia Secchiari, Andrea Ziblat, Ximena Lucía Raffo Iraolagoitia, Sol Yanel Nuñez, Mercedes Beatriz Fuertes, Carolina Ines Domaica, Jessica Mariel Sierra, Fernando P. Secin, Raul German Spallanzani
Publikováno v: Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Although natural killer (NK) cells infiltrate clear cell renal cell carcinomas (ccRCC), the most frequent malignancy of the kidney, tumor progression suggests that they become dysfunctional. As ccRCC-driven subversion of NK cell effector functions is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fab2200ad01e31c8a2f90da0db1c48b
https://www.frontiersin.org/articles/10.3389/fimmu.2021.681615/full
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4
Restoration of antitumor immunity through anti-MICA antibodies elicited with a chimeric protein
Autor: Carolina Ines Domaica, Kenneth W. Hance, Constanza Lauché, Kevin P. Madauss, Florencia Secchiari, Andrea Ziblat, Ximena Lucía Raffo Iraolagoitia, Fernando Alberto Goldbaum, Maria Cecilia Santilli, Nicolas Gilio, Sol Yanel Nuñez, Norberto Walter Zwirner, Evangelina Almada, Adrián Friedrich, Vanesa Zylberman, Mercedes Beatriz Fuertes, Jessica Mariel Sierra, Israel S. Gloger, Raul German Spallanzani, María Victoria Regge, Nicolás Torres, Romina Paola Pardo
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Journal for Immunotherapy of Cancer
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Background Natural killer and cytotoxic CD8+ T cells are major players during antitumor immunity. They express NKG2D, an activating receptor that promotes tumor elimination through recognition of the MHC class I chain-related proteins A and B (MICA a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a807302989d0c0cff85e03dae050930d
https://jitc.bmj.com/content/8/1/e000233.full
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5
Regulatory functions of NK cells during infections and cancer
Autor: Norberto Walter Zwirner, Carolina Ines Domaica, Mercedes Beatriz Fuertes
Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
After recognition, NK cells can kill susceptible target cells through perforin-dependent mechanisms or by inducing death receptor-mediated apoptosis, and they can also secrete cytokines that are pivotal for immunomodulation. Despite the critical role
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be9a34a7b580e589438c7090481f9db
https://pubmed.ncbi.nlm.nih.gov/33095941
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6
Human M2 Macrophages Limit NK Cell Effector Functions through Secretion of TGF-β and Engagement of CD85j
Autor: Sol Yanel Nuñez, Ximena Lucía Raffo Iraolagoitia, Mercedes Beatriz Fuertes, Andrea Ziblat, Carolina Ines Domaica, Norberto Walter Zwirner, Romina Elizabeth Araya, Jessica Mariel Sierra, Nicolás Torres, Florencia Secchiari
Publikováno v: The Journal of Immunology. 200:1008-1015
NK cells play important roles during immunosurveillance against tumors and viruses as they trigger cytotoxicity against susceptible cells and secrete pro-inflammatory cytokines such as IFN-g. In addition, upon activation, macrophages can become pro-i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578f143d9a39514674663a7e95d58222
https://doi.org/10.4049/jimmunol.1700737
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7
Immunomodulation of NK Cell Activity
Autor: Jessica Mariel Sierra, Mercedes Beatriz Fuertes, Norberto Walter Zwirner, Carolina Ines Domaica
Publikováno v: Methods in Molecular Biology ISBN: 9781071602027
Natural killer (NK) cells can kill virus-infected cells and tumor cells without prior sensitization and secrete numerous cytokines and chemokines that modulate the activity of different cells of the immune system. The recognition of target cells is m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7469bfd811885b0d47b74c257f55c1c3
https://doi.org/10.1007/978-1-0716-0203-4_9
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8
Interleukin (IL)-23 Stimulates IFN-γ Secretion by CD56bright Natural Killer Cells and Enhances IL-18-Driven Dendritic Cells Activation
Autor: Nicolás Torres, Jessica Mariel Sierra, Florencia Secchiari, Raul German Spallanzani, Carolina Ines Domaica, Ximena Lucía Raffo Iraolagoitia, Andrea Ziblat, Sol Yanel Nuñez, Norberto Walter Zwirner, Mercedes Beatriz Fuertes
Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 8 (2018)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Interleukin (IL)-23 is a member of the IL-12 family of cytokines that, as the other members of this family, is secreted by monocytes, macrophages, and dendritic cells (DC) upon recognition of bacterial, viral, and fungal components. IL-23 is critical
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e633f9a32f0ab815ca7fd2416065e51a
https://doi.org/10.3389/fimmu.2017.01959
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9
IL-27 stimulates human NK-cell effector functions and primes NK cells for IL-18 responsiveness
Autor: Damian Ezequiel Gualberto Avila, Carolina Ines Domaica, Ximena Lucía Raffo Iraolagoitia, Raul German Spallanzani, Lucas Ezequiel Rossi, Nicolás Torres, Norberto Walter Zwirner, Mercedes Beatriz Fuertes, Andrea Ziblat
Publikováno v: European Journal of Immunology. 45:192-202
IL-27, a member of the IL-12 family of cytokines, is produced by APCs, and displays pro- and anti-inflammatory effects. How IL-27 affects human NK cells still remains unknown. In this study, we observed that mature DCs secreted IL-27 and that blockad
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3246752d1d87e733dfb7e70b7bd19d2
https://doi.org/10.1002/eji.201444699
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10
Expansion of CD11b+Ly6G+Ly6Cint cells driven by medroxyprogesterone acetate in mice bearing breast tumors restrains NK cell effector functions
Autor: Ximena Lucía Raffo Iraolagoitia, Carolina Ines Domaica, Lucas Ezequiel Rossi, María Agustina Battistone, Mariana Salatino, Gabriel A. Rabinovich, Andrea Ziblat, Norberto W. Zwirner, Tomás Dalotto-Moreno, Raul German Spallanzani, Mercedes Beatriz Fuertes, Damian Ezequiel Gualberto Avila
Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
The progesterone analog medroxyprogesterone acetate (MPA) is widely used as a hormone replacement therapy in postmenopausal women and as contraceptive. However, prolonged administration of MPA is associated with increased incidence of breast cancer t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dcb63589fd9accb219e4ff5b7442734
https://doi.org/10.1007/s00262-013-1483-x
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