Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Carolina Gomes-Alexandre"'
Autor:
Mark C. Markowski, Mary-Ellen Taplin, Rahul Aggarwal, Laura A. Sena, Hao Wang, Hanfei Qi, Aliya Lalji, Victoria Sinibaldi, Michael A. Carducci, Channing J. Paller, Catherine H. Marshall, Mario A. Eisenberger, David E. Sanin, Srinivasan Yegnasubramanian, Carolina Gomes-Alexandre, Busra Ozbek, Tracy Jones, Angelo M. De Marzo, Samuel R. Denmeade, Emmanuel S. Antonarakis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Cyclic high-dose testosterone administration, known as bipolar androgen therapy (BAT), is a treatment strategy for patients with metastatic castration-resistant prostate cancer (mCRPC). Here, we report the results of a multicenter, single ar
Externí odkaz:
https://doaj.org/article/48b46172ca5a4aa0833d3da4c8f53c4c
Autor:
Laura A. Sena, Rajendra Kumar, David E. Sanin, Elizabeth A. Thompson, D. Marc Rosen, Susan L. Dalrymple, Lizamma Antony, Yuhan Yang, Carolina Gomes-Alexandre, Jessica L. Hicks, Tracy Jones, Kiara A. Bowers, Jillian N. Eskra, Jennifer Meyers, Anuj Gupta, Alyza Skaist, Srinivasan Yegnasubramanian, Jun Luo, W. Nathaniel Brennen, Sushant K. Kachhap, Emmanuel S. Antonarakis, Angelo M. De Marzo, John T. Isaacs, Mark C. Markowski, Samuel R. Denmeade
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 23 (2022)
Testosterone is the canonical growth factor of prostate cancer but can paradoxically suppress its growth when present at supraphysiological levels. We have previously demonstrated that the cyclical administration of supraphysiological androgen (SPA),
Externí odkaz:
https://doaj.org/article/1190b8e3606d4217ab6c491c95462033
Autor:
Onur Ertunc, Erica Smearman, Qizhi Zheng, Jessica L. Hicks, Jacqueline A. Brosnan-Cashman, Tracy Jones, Carolina Gomes-Alexandre, Levent Trabzonlu, Alan K. Meeker, Angelo M. De Marzo, Christopher M. Heaphy
Telomeres are terminal chromosomal elements that are essential for the maintenance of genomic integrity. The measurement of telomere content provides useful diagnostic and prognostic information, and fluorescent methods have been developed for this p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ef1a1ba0a18aa40f37adf6313ce02f2
https://doi.org/10.1101/2023.04.04.535575
https://doi.org/10.1101/2023.04.04.535575
Autor:
Carolina Gomes Alexandre, Jessica Hicks, Tracy Jones, John T Isaacs, Kiara Bowers, Alyza Skist, Laura Sena, Jennifer Meyers, Emmanuel Antonarakis, David Sanin, Hanfei Qi, Samuel Denmeade, Mark Markowski, Srinivasan Yegnasubramanian, Angelo De Marzo
Publikováno v:
Cancer Research. 83:4345-4345
While most patients with metastatic prostatic adenocarcinoma respond initially, nearly all develop resistance to multiple lines of androgen deprivation therapies. This is related to overexpression of the androgen receptor (AR), which is frequently dr
Autor:
Laura A Sena, Rajendra Kumar, David E Sanin, Elizabeth A Thompson, D Marc Rosen, Susan L Dalrymple, Lizamma Antony, Yuhan Yang, Carolina Gomes-Alexandre, Jessica L Hicks, Tracy Jones, Kiara A. Bowers, Jillian N Eskra, Jennifer Meyers, Anuj Gupta, Alyza Skaist, Srinivasan Yegnasubramanian, Jun Luo, W Nathaniel Brennen, Sushant K Kachhap, Emmanuel S Antonarakis, Angelo M De Marzo, John T Isaacs, Mark C Markowski, Samuel R Denmeade
Testosterone is the canonical growth factor of prostate cancer but can paradoxically suppress its growth when present at supraphysiological levels. We have previously demonstrated that the cyclical administration of supraphysiological androgen (SPA),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d82b47707259bc746b90babc396b6619
https://doi.org/10.1101/2022.04.26.22274275
https://doi.org/10.1101/2022.04.26.22274275
Autor:
Busra Ozbek, Onur Ertunc, Andrew Erickson, Igor D. Vidal, Carolina Gomes‐Alexandre, Gunes Guner, Jessica L. Hicks, Tracy Jones, Janis M. Taube, Karen S. Sfanos, Srinivasan Yegnasubramanian, Angelo M. De Marzo
Publikováno v:
The Prostate. 82
Autor:
Srinivasan Yegnasubramanian, Janis M. Taube, Angelo M. De Marzo, Busra Ozbek, Carolina Gomes Alexandre, Onur Ertunc, Tracy Jones, Andrew Erickson, Jessica L. Hicks, Karen S. Sfanos, Gunes Guner, Igor Vidal
Background Most prostate cancers are "immune cold" and poorly responsive to immune checkpoint inhibitors. However, the mechanisms responsible for the lack of a robust antitumor adaptive immune response in the prostate are poorly understood, which hin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c591f71687247183a020de67df431d23
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/96552
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/96552
Autor:
Carolina Gomes Alexandre, Tracy Jones, Jessica L. Hicks, John T. Isaacs, Anuj Gupta, Alyza Skaist, Laura Sena, Jennifer Meyers, Emmanuel Antonarakis, Mark Markowski, Samuel Denmeade, Srinivasan Yegnasubramanian, Angelo Michael De Marzo
Publikováno v:
Cancer Research. 82:653-653
Molecular analysis of tissue samples from metastatic cancer lesions can improve our understanding of drug response and resistance. Since prostate cancer cells initially require androgen signaling through the androgen receptor (AR) for proliferation,
Autor:
Mark Christopher Markowski, Mary-Ellen Taplin, Rahul Raj Aggarwal, Laura Sena, Hao Wang, Aliya Lalji, Jennifer Meyers, Alyza Skaist, Anuj Gupta, Carolina Gomes-Alexandre, Tracy Jones, Jessica Hicks, Sushant Kachhap, Srinivasan Yegnasubramanian, Angelo M De Marzo, Samuel R. Denmeade, Emmanuel S. Antonarakis
Publikováno v:
Journal of Clinical Oncology. 40:5064-5064
5064 Background: During BAT, intramuscular (IM) administration of testosterone (T) results in rapid cycling of serum T from supraphysiologic to near-castrate levels in men with mCRPC. In a retrospective study, clinical responses to immune checkpoint