Subcellular Localization of Matrin 3 Containing Mutations Associated with ALS and Distal Myopathy.

Autor: M Carolina Gallego-Iradi, Alexis M Clare, Hilda H Brown, Christopher Janus, Jada Lewis, David R Borchelt

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0142144 (2015)

Mutations in Matrin 3 [MATR3], an RNA- and DNA-binding protein normally localized to the nucleus, have been linked to amyotrophic lateral sclerosis (ALS) and distal myopathies. In the present study, we have used transient transfection of cultured cel

Externí odkaz: https://doaj.org/article/ee9ff757edba4919afbe11983b73032d

Heterogeneity of Matrin 3 in the developing and aging murine central nervous system

Autor: Colin Duffy, Simon D'Alton, Mariela Cabrera, John Howard, Carolina Gallego-Iradi, Abigail R. Hernandez, David R. Borchelt, Keith Crosby, Sruti Rayaprolu, Christina Moloney, Zoe Siemienski, Jada Lewis

Publikováno v: Journal of Comparative Neurology. 524:2740-2752

Mutations in the MATR3 gene encoding the nucleotide binding protein Matrin 3 have recently been identified as causing a subset of familial amyotrophic lateral sclerosis (fALS) and more rarely causing distal myopathy. Translating the identification of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e4dce83b4fe786b38162e6c32a91f2a
https://doi.org/10.1002/cne.23986

Alzheimer’s disease in humans and other animals; a consequence of post-reproductive lifespan and longevity rather than ageing

Autor: María Carolina Gallego Iradi, Frank J. Gunn-Moore, Simon Lovestone, Oksana Kaidanovich-Beilin, Danielle Gunn-Moore

Publikováno v: Gunn-Moore, D, Kaidanovich-Beilin, O, Iradi, M C G, Gunn-Moore, F & Lovestone, S 2018, ' Alzheimer's disease in humans and other animals; a consequence of post-reproductive lifespan and longevity rather than ageing ', Alzheimer's & Dementia, vol. 14, no. 2, pp. 195-204 . https://doi.org/10.1016/j.jalz.2017.08.014

Research in the author’s laboratories is supported by the NIHR, MRC, ARUK, Alzheimer’s Society, Wellcome Trust and the EU Introduction Alzheimer's disease and diabetes mellitus are linked by epidemiology, genetics, and molecular pathogenesis. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f02211191a3f71580c2db5125a489c5f
https://doi.org/10.1016/j.jalz.2017.08.014

Subcellular Localization of Matrin 3 Containing Mutations Associated with ALS and Distal Myopathy

Autor: Christopher Janus, Hilda Brown, David R. Borchelt, Jada Lewis, M. Carolina Gallego-Iradi, Alexis M. Clare

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0142144 (2015)
PLoS ONE

Background Mutations in Matrin 3 [MATR3], an RNA- and DNA-binding protein normally localized to the nucleus, have been linked to amyotrophic lateral sclerosis (ALS) and distal myopathies. In the present study, we have used transient transfection of c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816a17c4eae7e2332bd838add424de2e
http://europepmc.org/articles/PMC4631352?pdf=render

N-terminal sequences in matrin 3 mediate phase separation into droplet-like structures that recruit TDP43 variants lacking RNA binding elements.

Autor: Gallego-Iradi, M. Carolina, Strunk, Haley, Crown, Anthony M., Davila, Rachel, Brown, Hilda, Rodriguez-Lebron, Edgardo, Borchelt, David R.

Publikováno v: Laboratory Investigation (00236837); Jul2019, Vol. 99 Issue 7, p1030-1040, 11p