Výsledky vyhledávání - "Carolina B Moraes"

Akademický článek

Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity

Autor: Bianca Zingales, Michael A Miles, Carolina B Moraes, Alejandro Luquetti, Felipe Guhl, Alejandro G Schijman, Isabela Ribeiro

Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 109, Iss 6, Pp 828-833 (2014)

This opinion piece presents an approach to standardisation of an important aspect of Chagas disease drug discovery and development: selecting Trypanosoma cruzi strains for in vitro screening. We discuss the rationale for strain selection representing

Externí odkaz: https://doaj.org/article/0a9861aadc0b4e698760d43224f291f9

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Akademický článek

Transcription sites are developmentally regulated during the asexual cycle of Plasmodium falciparum.

Autor: Carolina B Moraes, Thierry Dorval, Mónica Contreras-Dominguez, Fernando de M Dossin, Michael A E Hansen, Auguste Genovesio, Lucio H Freitas-Junior

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e55539 (2013)

Increasing evidence shows that the spatial organization of transcription is an important epigenetic factor in eukaryotic gene regulation. The malaria parasite Plasmodium falciparum shows a remarkably complex pattern of gene expression during the eryt

Externí odkaz: https://doaj.org/article/1fe60d5a4bb1433f93b7d17dacd381e0

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Akademický článek

Automated nuclear analysis of Leishmania major telomeric clusters reveals changes in their organization during the parasite's life cycle.

Autor: Fernando de M Dossin, Alexandre Dufour, Elodie Dusch, Jair L Siqueira-Neto, Carolina B Moraes, Gyong Seon Yang, Maria Isabel Cano, Auguste Genovesio, Lucio H Freitas-Junior

Publikováno v: PLoS ONE, Vol 3, Iss 6, p e2313 (2008)

Parasite virulence genes are usually associated with telomeres. The clustering of the telomeres, together with their particular spatial distribution in the nucleus of human parasites such as Plasmodium falciparum and Trypanosoma brucei, has been sugg

Externí odkaz: https://doaj.org/article/f1c4d858746544188271ca2723d0bf27

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Akademický článek

Micro-Addition of Silver to Copper: One Small Step in Composition, a Change for a Giant Leap in Biocidal Activity

Autor: Vitor G. Vital, Márcio R. Silva, Vinicius T. Santos, Flávia G. Lobo, Patrícia Xander, Rogéria C. Zauli, Carolina B. Moraes, Lucio H. Freitas-Junior, Cecíla G. Barbosa, Diogo S. Pellosi, Ricardo A. G. Silva, André Paganotti, Suzan P. Vasconcellos

Publikováno v: Materials, Vol 17, Iss 4, p 917 (2024)

The use of copper as an antimicrobial agent has a long history and has gained renewed interest in the context of the COVID-19 pandemic. In this study, the authors investigated the antimicrobial properties of an alloy composed of copper with a small p

Externí odkaz: https://doaj.org/article/a69aaa9e557242d587d6d9490536692a

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Akademický článek

Antiviral Action against SARS-CoV-2 of a Synthetic Peptide Based on a Novel Defensin Present in the Transcriptome of the Fire Salamander (Salamandra salamandra)

Publikováno v: Pharmaceutics, Vol 16, Iss 2, p 190 (2024)

The potential emergence of zoonotic diseases has raised significant concerns, particularly in light of the recent pandemic, emphasizing the urgent need for scientific preparedness. The bioprospection and characterization of new molecules are strategi

Externí odkaz: https://doaj.org/article/88bb49986b8a49bbb99eea8a6216e672

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Akademický článek

Non-Toxic Dimeric Peptides Derived from the Bothropstoxin-I Are Potent SARS-CoV-2 and Papain-like Protease Inhibitors

Publikováno v: Molecules, Vol 26, Iss 16, p 4896 (2021)

The COVID-19 outbreak has rapidly spread on a global scale, affecting the economy and public health systems throughout the world. In recent years, peptide-based therapeutics have been widely studied and developed to treat infectious diseases, includi

Externí odkaz: https://doaj.org/article/9de96259efb449498e199a11622b3e44

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Akademický článek

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery

Publikováno v: ACS Omega, Vol 2, Iss 9, Pp 5666-5683 (2017)

Externí odkaz: https://doaj.org/article/5c64fcc1dcb6440098320d12bd53e394

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Ecofriendly aminochalcogenation of alkenes: a green alternative to obtain compounds with potential anti-SARS-CoV-2 activity

Autor: Luana S. Gomes, José S. S. Neto, Iris di Leo, Cecília G. Barbosa, Carolina B. Moraes, Lucio H. Freitas-Junior, Bruno Rizzuti, Claudio Santi, Vanessa Nascimento

We report a solvent- and metal-free methodology for the aminochalcogenation of alkenes, using I2/DMSO as catalytic system, under microwave irradiation. Some of the obtained compounds showed potent antiviral activity against the coronavirus SARS-CoV-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8058fe4f123edce7de49000f53279d
https://hdl.handle.net/11391/1553960

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Akademický článek

A Multi-Species Phenotypic Screening Assay for Leishmaniasis Drug Discovery Shows That Active Compounds Display a High Degree of Species-Specificity

Autor: Laura M. Alcântara, Thalita C. S. Ferreira, Vanessa Fontana, Eric Chatelain, Carolina B. Moraes, Lucio H. Freitas-Junior

Publikováno v: Molecules, Vol 25, Iss 11, p 2551 (2020)

High genetic and phenotypic variability between Leishmania species and strains within species make the development of broad-spectrum antileishmanial drugs challenging. Thus, screening panels consisting of several diverse Leishmania species can be use

Externí odkaz: https://doaj.org/article/ae414627f8eb4f7cb62110520c16a223

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