Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Carolina Alquezar"'
Autor:
Celeste M. Karch, Aimee W. Kao, Anna Karydas, Khadijah Onanuga, Rita Martinez, Andrea Argouarch, Chao Wang, Cindy Huang, Peter Dongmin Sohn, Kathryn R. Bowles, Salvatore Spina, M. Catarina Silva, Jacob A. Marsh, Simon Hsu, Derian A. Pugh, Nupur Ghoshal, Joanne Norton, Yadong Huang, Suzee E. Lee, William W. Seeley, Panagiotis Theofilas, Lea T. Grinberg, Fermin Moreno, Kathryn McIlroy, Bradley F. Boeve, Nigel J. Cairns, John F. Crary, Stephen J. Haggarty, Justin K. Ichida, Kenneth S. Kosik, Bruce L. Miller, Li Gan, Alison M. Goate, Sally Temple, Carolina Alquezar, Kathryn Bowles, David Butler, Israel Hernandez, Valerie Hennes, Martin Kampmann
Publikováno v:
Stem Cell Reports, Vol 13, Iss 5, Pp 939-955 (2019)
Summary: Primary tauopathies are characterized neuropathologically by inclusions containing abnormal forms of the microtubule-associated protein tau (MAPT) and clinically by diverse neuropsychiatric, cognitive, and motor impairments. Autosomal domina
Externí odkaz:
https://doaj.org/article/598d132842794126ace928eb080d817b
Publikováno v:
Antioxidants, Vol 11, Iss 8, p 1421 (2022)
Oxidative stress (OS) is the result of an imbalance between the production of reactive oxygen species (ROS) and the antioxidant capacity of cells. Due to its high oxygen demand, the human brain is highly susceptible to OS and, thus, it is not a surpr
Externí odkaz:
https://doaj.org/article/cc9aa9bf331c42f1b0065cc4414e2c5f
Publikováno v:
Frontiers in Neurology, Vol 11 (2021)
Post-translational modifications (PTMs) on tau have long been recognized as affecting protein function and contributing to neurodegeneration. The explosion of information on potential and observed PTMs on tau provides an opportunity to better underst
Externí odkaz:
https://doaj.org/article/6dd3d1dd45cb4609b7755ad5686e6998
Autor:
Ji-Hye L. Hwang, Olga S. Perloff, Stephanie E. Gaus, Camila Benitez, Carolina Alquezar, Celica Q. Cosme, Alissa L. Nana, Sarat C. Vatsavayai, Eliana M. Ramos, Daniel H. Geschwind, Bruce L. Miller, Aimee W. Kao, William W. Seeley
Publikováno v:
Acta Neuropathol
Acta neuropathologica, vol 145, iss 1
Acta neuropathologica, vol 145, iss 1
Tuberous sclerosis complex (TSC) is a neurogenetic disorder leading to epilepsy, developmental delay, and neurobehavioral dysfunction. The syndrome is caused by pathogenic variants in TSC1 (coding for hamartin) or TSC2 (coding for tuberin). Recently,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2ccbd5a1be1a194149fd8dcce8994c
https://europepmc.org/articles/PMC10244026/
https://europepmc.org/articles/PMC10244026/
Publikováno v:
Antioxidants (Basel, Switzerland). 11(8)
Oxidative stress (OS) is the result of an imbalance between the production of reactive oxygen species (ROS) and the antioxidant capacity of cells. Due to its high oxygen demand, the human brain is highly susceptible to OS and, thus, it is not a surpr
Autor:
Aimee W. Kao, Austin L Wang, Anand Patwardhan, Michael Grabe, Phi T. Nguyen, Kean-Hooi Ang, Anna V. Molofsky, Carolina Alquezar, Michelle R. Arkin, Marcus Y. Chin, Mackenzie Welch
Publikováno v:
ACS Sensors
ACS sensors, vol 6, iss 6
ACS sensors, vol 6, iss 6
Lysosomes are important sites for macromolecular degradation, defined by an acidic lumenal pH of ∼4.5. To better understand lysosomal pH, we designed a novel, genetically encoded, fluorescent protein (FP)-based pH biosensor called Fluorescence Indi
Autor:
Marcus Y. Chin, Kean-Hooi Ang, Julia Davies, Carolina Alquezar, Virginia G. Garda, Brendan Rooney, Kun Leng, Martin Kampmann, Michelle R. Arkin, Aimee W. Kao
Publikováno v:
ACS chemical neuroscience, vol 13, iss 10
Lysosomes are intracellular organelles responsible for the degradation of diverse macromolecules in a cell. A highly acidic pH is required for the optimal functioning of lysosomal enzymes. Loss of lysosomal intralumenal acidity can disrupt cellular p
Autor:
Concepción Pérez, María L. de Ceballos, Pedro González-Naranjo, Fernando Bartolomé, Nuria E. Campillo, Emilio Nuñez-Borque, Alejandro Reinares-Sebastián, Juan A. Páez, Carolina Alquezar, Ángeles Martín-Requero
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
43 p.-8 fig.-2 tab.
Alzheimer's disease (AD), the leading cause of dementia in the elderly, is a neurodegenerative disorder marked by progressive impairment of cognitive ability. Patients with AD display neuropathological lesions including senil
Alzheimer's disease (AD), the leading cause of dementia in the elderly, is a neurodegenerative disorder marked by progressive impairment of cognitive ability. Patients with AD display neuropathological lesions including senil
Autor:
Dennis W. Dickson, Jennifer S. Yokoyama, Alma L. Burlingame, Eliana Marisa Ramos, Carolina Alquezar, Gerard D. Schellenberg, Beth A. Dombroski, Ana Maria Cuervo, Kathleen M. Schoch, Aimee W. Kao, Aurora Scrivo, Elisabeth E. Mlynarski, Ethan G. Geier, Michael DeTure, Bruce L. Miller, Andrea R. Argouarch, Kathy H. Li, Timothy M. Miller
Publikováno v:
Science Advances
Description
TSC1/hamartin haploinsufficiency increases risk for tauopathy by promoting tau acetylation and accumulation.
Age-associated neurodegenerative disorders demonstrating tau-laden intracellular inclusions are known as tauopathies. W
TSC1/hamartin haploinsufficiency increases risk for tauopathy by promoting tau acetylation and accumulation.
Age-associated neurodegenerative disorders demonstrating tau-laden intracellular inclusions are known as tauopathies. W
Autor:
Jennifer S. Yokoyama, Ka Wan Li, Elisabeth E. Mlynarski, Aurora Scrivo, Ethan G. Geier, Aimee W. Kao, Alma L. Burlingame, Bruce L. Miller, Ana Maria Cuervo, Carolina Alquezar, Schellenberg Gd, Kathleen M. Schoch, Eliana Marisa Ramos, Timothy M. Miller, Beth A. Dombroski, Andrea R. Argouarch
Age-associated neurodegenerative disorders demonstrating tau-laden intracellular inclusions, including Alzheimer’s disease (AD), frontotemporal lobar degeneration (FTLD) and progressive supranuclear palsy (PSP), are collectively known as tauopathie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bed079a2f721490d28d13ea0024b8de0
https://doi.org/10.1101/2020.11.08.371922
https://doi.org/10.1101/2020.11.08.371922