NSMCE2, a novel super-enhancer-regulated gene, is linked to poor prognosis and therapy resistance in breast cancer

Autor: Carolina Di Benedetto, Justin Oh, Zainab Choudhery, Weiquan Shi, Gilmer Valdes, Paola Betancur

Publikováno v: BMC Cancer, Vol 22, Iss 1, Pp 1-16 (2022)

Abstract Background Despite today’s advances in the treatment of cancer, breast cancer-related mortality remains high, in part due to the lack of effective targeted therapies against breast tumor types that do not respond to standard treatments. Th

Externí odkaz: https://doaj.org/article/243665a7d5784c99a0993ab14f3c8f71

Dynamic regulation of Pin1 expression and function during zebrafish development.

Autor: Maria Solange Ibarra, Carla Borini Etichetti, Carolina Di Benedetto, Germán L Rosano, Ezequiel Margarit, Giannino Del Sal, Marina Mione, Javier Girardini

Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0175939 (2017)

The prolyl isomerase Pin1 plays a key role in the modulation of proline-directed phosphorylation signaling by inducing local conformational changes in phosphorylated protein substrates. Extensive studies showed different roles for Pin1 in physiologic

Externí odkaz: https://doaj.org/article/5f6106546d0f46369ca0b530ccc3e8f7

Enhancer Clusters Drive Type I Interferon-Induced TRAIL Overexpression in Cancer, and Its Intracellular Protein Accumulation Fails to Induce Apoptosis

Autor: Carolina Di Benedetto, Taimoor Khan, Santiago Serrano-Saenz, Anthony Rodriguez-Lemus, Chananat Klomsiri, Tim-Mathis Beutel, Alysia Thach, Henning Walczak, Paola Betancur

Publikováno v: Cancers
Volume 15
Issue 3
Pages: 967

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine produced and secreted by immune cells in response to an infection, often in response to interferon (IFN) stimulation. In cancer, it has also been shown that IFN stimulates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6316a937b3ee8e8b64a0aa33e4aa5a8
https://doi.org/10.3390/cancers15030967

Isoprenylcysteine carboxy methyltransferase (ICMT) is associated with tumor aggressiveness and its expression is controlled by the p53 tumor suppressor

Autor: Silvio Bicciato, Mauricio Menacho-Márquez, Carla Borini Etichetti, Javier E. Girardini, Carolina Rossi, Carolina Di Benedetto, Giannino Del Sal, María Virginia Baglioni

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Isoprenyl cysteine carboxyl methyltransferase (ICMT) plays a key role in post-translational regulation of prenylated proteins. On the basis of previous results, we hypothesized that the p53 pathway and ICMT expression may be linked in cancer cells. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02af7a4d2ced8ae6eebf94af278c40d3
https://hdl.handle.net/11380/1173964

Dynamic regulation of Pin1 expression and function during zebrafish development

Autor: Carolina Di Benedetto, Marina Mione, Javier E. Girardini, Ezequiel Margarit, Carla M. Borini Etichetti, Giannino Del Sal, Maria Solange Ibarra, Germán L. Rosano

Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0175939 (2017)
PLoS ONE
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

The prolyl isomerase Pin1 plays a key role in the modulation of proline-directed phosphorylation signaling by inducing local conformational changes in phosphorylated protein substrates. Extensive studies showed different roles for Pin1 in physiologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d1b54a8541a60c9cde962b4c4f78e2
https://doi.org/10.1371/journal.pone.0175939