Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Carolin Tauber"'
Autor:
Daniel Becker, Zuzanna Kaczmarska, Christoph Arkona, Robert Schulz, Carolin Tauber, Gerhard Wolber, Rolf Hilgenfeld, Miquel Coll, Jörg Rademann
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Molecular fragments are useful tools in drug-discovery but they might be hard to identify due to their weak affinity to the targets. Here, the authors use a protein-templated assembly to design high affinity inhibitors of Coxsackie virus 3C protease,
Externí odkaz:
https://doaj.org/article/a53d99ca5b15420c94025185b9b89835
Autor:
Gerhard Wolber, Robert Schulz, Christoph Arkona, Umer Bin Abdul Aziz, Carolin Tauber, Szymon Pach, Jörg Rademann, Dirk Jochmans, Johan Neyts, Marisa Tügend, Rebekka Wamser
Publikováno v:
Angewandte Chemie. 133:13405-13413
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fc88ec4220c973f78e72fc5fd970e33
https://doi.org/10.1002/ange.202102074
https://doi.org/10.1002/ange.202102074
Autor:
Gerhard Wolber, Szymon Pach, Jörg Rademann, Carolin Tauber, Johan Neyts, Dirk Jochmans, Marisa Tügend, Robert Schulz, Christoph Arkona, Umer Bin Abdul Aziz, Rebekka Wamser
Publikováno v:
Angewandte Chemie (International Ed. in English)
The generation of bioactive molecules from inactive precursors is a crucial step in the chemical evolution of life, however, mechanistic insights into this aspect of abiogenesis are scarce. Here, we investigate the protein‐catalyzed formation of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3efdcbabbb8a8dfdfc7b8dfd2ad33a44
https://lirias.kuleuven.be/handle/123456789/676358
https://lirias.kuleuven.be/handle/123456789/676358
Autor:
Hassan H. Farag, Daniel Becker, Carolin Tauber, Franziska Gottschalk, Robert Schulz, Gerhard Wolber, Stefan Wagner, Amira Atef, Atef A. Abdel-Hafez, Christoph Arkona, Jörg Rademann
Publikováno v:
Journal of Medicinal Chemistry. 61:1218-1230
Lead structure discovery mainly focuses on the identification of noncovalently binding ligands. Covalent linkage, however, is an essential binding mechanism for a multitude of successfully marketed drugs, although discovered by serendipity in most ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4f0d224f78df1d0e5a6c7854b232ee
https://doi.org/10.1021/acs.jmedchem.7b01440
https://doi.org/10.1021/acs.jmedchem.7b01440
Publikováno v:
Angewandte Chemie (Weinheim an Der Bergstrasse, Germany)
Proteintemplat‐gesteuerte Fragmentligationen sind ein neuartiges Konzept zur Unterstützung der Wirkstofffindung und können dazu beitragen, die Wirksamkeit von Proteinliganden zu verbessern. Es handelt sich dabei um chemische Reaktionen zwischen n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2498ff7aeb1ff6a5aa94c0bff0170a86
https://doi.org/10.1002/ange.201610372
https://doi.org/10.1002/ange.201610372
Publikováno v:
Angewandte Chemie (International Ed. in English)
Protein‐templated fragment ligation is a novel concept to support drug discovery and can help to improve the efficacy of protein ligands. Protein‐templated fragment ligations are chemical reactions between small molecules (“fragments”) utiliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dae202d3124d5ded212cf64d52d4d0c6
http://europepmc.org/articles/PMC7159684
http://europepmc.org/articles/PMC7159684