Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Carolin Schaab"'
Autor:
Harald Hübner, Tamara Schellhorn, Marie Gienger, Carolin Schaab, Jonas Kaindl, Laurin Leeb, Timothy Clark, Dorothee Möller, Peter Gmeiner
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
G protein-coupled receptors (GPCRs) are involved in key signalling pathways and represent important targets for the treatment of neurological and psychiatric disorders. Here, the authors describe powerful bivalent ligands that efficiently bind to the
Externí odkaz:
https://doaj.org/article/0157f3da6f7d40b3b16bfeb4284db320
Autor:
Laurin Leeb, Harald Hübner, Timothy Clark, Dorothee Möller, Marie Gienger, Tamara Schellhorn, Peter Gmeiner, Jonas Kaindl, Carolin Schaab
Publikováno v:
Hübner, H, Schellhorn, T, Gienger, M, Schaab, C, Kaindl, J, Leeb, L, Clark, T, Möller, D & Gmeiner, P 2016, ' Structure-guided development of heterodimer-selective GPCR ligands ', Nature Communications, vol. 7, 12298 . https://doi.org/10.1038/ncomms12298
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Nature Communications
Crystal structures of G protein-coupled receptor (GPCR) ligand complexes allow a rational design of novel molecular probes and drugs. Here we report the structure-guided design, chemical synthesis and biological investigations of bivalent ligands for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885e9600a0732f29147d6f7ddbd70b1e
https://researchportal.port.ac.uk/portal/en/publications/structureguided-development-of-heterodimerselective-gpcr-ligands(96948b26-114b-4727-a1bf-11d48bcca215).html
https://researchportal.port.ac.uk/portal/en/publications/structureguided-development-of-heterodimerselective-gpcr-ligands(96948b26-114b-4727-a1bf-11d48bcca215).html
Autor:
Harald Hübner, Peter Gmeiner, Carolin Schaab, Dieter Seebach, Jürgen Einsiedel, Timothy Clark, Ralf C. Kling
Publikováno v:
ChemistryOpen
ChemistryOpen, 3 (5)
ChemistryOpen, 3 (5)
Subtype‐selective agonists of the neurotensin receptor NTS2 represent a promising option for the treatment of neuropathic pain, as NTS2 is involved in the mediation of μ‐opioid‐independent anti‐nociceptive effects. Based on the crystal struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71417e00b586fa9714049c3dbffc6468