Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Carolin Sailer"'
Autor:
Carolin Sailer, Jasmin Jansen, Kamil Sekulski, Victor E. Cruz, Jan P. Erzberger, Florian Stengel
Publikováno v:
Cell Reports, Vol 38, Iss 6, Pp 110353- (2022)
Summary: Eukaryotic ribosome biogenesis is facilitated and regulated by numerous ribosome biogenesis factors (RBFs). High-resolution cryoelectron microscopy (cryo-EM) maps have defined the molecular interactions of RBFs during maturation, but many tr
Externí odkaz:
https://doaj.org/article/26f8ca74ad9340298955aadc5d369c4e
Autor:
Annette Aichem, Carolin Sailer, Stella Ryu, Nicola Catone, Nicolas Stankovic-Valentin, Gunter Schmidtke, Frauke Melchior, Florian Stengel, Marcus Groettrup
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
FAT10 is an ubiquitin-like modifier that targets proteins to proteasomal degradation. Here, the authors show that FAT10 also regulates SUMO activation in vitro and in cells, providing evidence for functional crosstalk between two ubiquitin-like modif
Externí odkaz:
https://doaj.org/article/c189585808444a29aa898a977aa4e6e8
Autor:
Carolin Sailer, Fabian Offensperger, Alexandra Julier, Kai-Michael Kammer, Ryan Walker-Gray, Matthew G. Gold, Martin Scheffner, Florian Stengel
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Oncoprotein E6 facilitates the E6AP-catalyzed ubiquitination of p53. Here, the authors study the structural basis of this process by qualitative and quantitative cross-linking mass spectrometry, providing insights into E6AP-E6-p53 complex assembly an
Externí odkaz:
https://doaj.org/article/665259f0303c4a7a8d8b890e1f4e21c3
Autor:
Vasileios Kargas, Pablo Castro-Hartmann, Norberto Escudero-Urquijo, Kyle Dent, Christine Hilcenko, Carolin Sailer, Gertrude Zisser, Maria J Marques-Carvalho, Simone Pellegrino, Leszek Wawiórka, Stefan MV Freund, Jane L Wagstaff, Antonina Andreeva, Alexandre Faille, Edwin Chen, Florian Stengel, Helmut Bergler, Alan John Warren
Publikováno v:
eLife, Vol 8 (2019)
During their final maturation in the cytoplasm, pre-60S ribosomal particles are converted to translation-competent large ribosomal subunits. Here, we present the mechanism of peptidyltransferase centre (PTC) completion that explains how integration o
Externí odkaz:
https://doaj.org/article/68e853793d0c4ab19d7cce1b81cf73da
Autor:
Xingyu Chen, Carolin Sailer, Kai Michael Kammer, Julius Fürsch, Markus R. Eisele, Eri Sakata, Riccardo Pellarin, Florian Stengel
Cross-linking mass spectrometry (XL-MS) has become an indispensable tool for the emerging field of systems structural biology over the recent years. However, the confidence in individual protein–protein interactions (PPIs) depends on the correct as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf3aced744b2b86d4af59b28266e69d
Autor:
Michael Prattes, Irina Grishkovskaya, Victor-Valentin Hodirnau, Christina Hetzmannseder, Gertrude Zisser, Carolin Sailer, Vasileios Kargas, Mathias Loibl, Magdalena Gerhalter, Lisa Kofler, Alan J. Warren, Florian Stengel, David Haselbach, Helmut Bergler
The AAA-ATPase Drg1 is a key factor in eukaryotic ribosome biogenesis that initiates cytoplasmic maturation of the large ribosomal subunit. Drg1 releases the shuttling maturation factor Rlp24 from pre-60S particles shortly after nuclear export, a str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd07e03705a95145eca7d2002ac8dbb5
https://www.repository.cam.ac.uk/handle/1810/341317
https://www.repository.cam.ac.uk/handle/1810/341317
Autor:
Victor Emmanuel Cruz, Kamil Sekulski, Nagesh Peddada, Carolin Sailer, Sahana Balasubramanian, Christine S. Weirich, Florian Stengel, Jan P. Erzberger
DEAD-box ATPases are ubiquitous enzymes essential in all aspects of RNA biology. However, the limited in vitro catalytic activities described for these enzymes is at odds with their complex cellular roles, most notably in driving large-scale RNA remo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c16224832bb435f0c2ca92b43c2393e9
https://doi.org/10.1101/2022.02.24.481786
https://doi.org/10.1101/2022.02.24.481786
Autor:
Xingyu Chen, Carolin Sailer, Kai Michael Kammer, Julius Fürsch, Markus R. Eisele, Eri Sakata, Florian Stengel
Cross-Linking Mass Spectrometry (XL-MS) has become an indispensable tool for the emerging field of systems structural biology over the recent years. However, the confidence in individual protein-protein interactions (PPIs) depends on the correct asse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7f8a1a7b9a99396771a052d65bb564c
https://doi.org/10.1101/2022.02.03.478943
https://doi.org/10.1101/2022.02.03.478943
SummaryEukaryotic ribosome biogenesis is facilitated and regulated by numerous ribosome biogenesis factors (RBFs). High-resolution cryo-EM maps have defined the molecular interactions of RBFs during maturation, but many transient and dynamic interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d815d95799f852c73d855c1f35f701f3
https://doi.org/10.1101/2021.05.11.443624
https://doi.org/10.1101/2021.05.11.443624
Autor:
Nicola Catone, Frauke Melchior, Florian Stengel, Marcus Groettrup, Annette Aichem, Gunter Schmidtke, Nicolas Stankovic-Valentin, Stella Ryu, Carolin Sailer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications
The covalent attachment of the cytokine-inducible ubiquitin-like modifier HLA-F adjacent transcript 10 (FAT10) to hundreds of substrate proteins leads to their rapid degradation by the 26 S proteasome independently of ubiquitylation. Here, we identif