Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Carolin Purmann"'
Autor:
Xianglong Zhang, Ying Zhang, Xiaowei Zhu, Carolin Purmann, Michael S. Haney, Thomas Ward, Arineh Khechaduri, Jie Yao, Sherman M. Weissman, Alexander E. Urban
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Copy number variants in the human genome (CNVs) are associated with neurodevelopmental and psychiatric disorders such as schizophrenia and autism. Here the authors investigate how the large deletion CNV on chromosome 22q11.2 alters chromatin organiza
Externí odkaz:
https://doaj.org/article/e9aab59abbe142e29443cfd1acc2965a
Autor:
Xianglong Zhang, Alexander E. Urban, Wing Hung Wong, Shining Ma, Reenal Pattni, Carolin Purmann, Kasey N. Davis, Joachim Hallmayer, Anima Shrestha, Marcus Ho, Yiling Huang, Jonathan A. Bernstein, Siming Zhang
Publikováno v:
Biol Psychiatry
Background The 15q13.3 microdeletion is associated with several neuropsychiatric disorders, including autism and schizophrenia. Previous association and functional studies have investigated the potential role of several genes within the deletion in n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af5550cd59299f953c2434e1bbe995f2
https://doi.org/10.1016/j.biopsych.2020.06.021
https://doi.org/10.1016/j.biopsych.2020.06.021
Autor:
Shi-Bin Li, Valentina Martinez Damonte, Chong Chen, Gordon X. Wang, Justus M. Kebschull, Hiroshi Yamaguchi, Wen-Jie Bian, Carolin Purmann, Reenal Pattni, Alexander Eckehart Urban, Philippe Mourrain, Julie A. Kauer, Grégory Scherrer, Luis de Lecea
Publikováno v:
Science
INTRODUCTION: Sleep destabilization is strongly associated with aging and cognitive function decline. Despite sleep fragmentation being central to the most prevalent complaints of sleep problems in elderly populations, the mechanistic underpinnings o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c117e92fda14fd45b62d9ff2986465
https://doi.org/10.1126/science.abh3021
https://doi.org/10.1126/science.abh3021
Autor:
Alexis Mitelpunkt, Koji Tanabe, Anshul Kundaje, Wing Hung Wong, Cheen Euong Ang, Jonathan A. Bernstein, Tamas Danko, Soumya Kundu, Bruce J. Aronow, Joachim Hallmayer, Carolin Purmann, Alexander E. Urban, Shining Ma, Thomas C. Südhof, Yue Zhang, Marius Wernig
Standard methods for the creation of neuronal cells via direct induction from primary tissue use perinatal fibroblasts, which hinders the important study of patient specific genetic lesions such as those underlying neuropsychiatric disorders. To addr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ac794fc56f488fdc1f69e3270cabe91
https://doi.org/10.1101/2021.10.14.464344
https://doi.org/10.1101/2021.10.14.464344
Autor:
Philip Dexheimer, Jeffrey L. Dage, Xianglong Zhang, Thomas J. Ward, Yu-Wen Alvin Huang, Yingfei Liu, Marius Wernig, Zhiping P. Pang, Tamas Danko, ChangHui Pak, Jinzhao Wang, Vincent R. Mirabella, Kang Jin, Michael McLachlan, Madhuri Vangipuram, Carolin Purmann, Jennifer C. Moore, Junyi Ma, Bradley J. Swanson, Sarah Grieder, Eric E. Bardes, Douglas F. Levinson, Alexis Mitelpunkt, Bruce J. Aronow, Alexander E. Urban, Thomas C. Südhof, Pingping Qu
Publikováno v:
Proc Natl Acad Sci U S A
Heterozygous NRXN1 deletions constitute the most prevalent currently known single-gene mutation predisposing to schizophrenia. Previous studies showed that engineered heterozygous NRXN1 deletions impaired neurotransmitter release in human neurons, su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4862173dfbc4ea72fe8169d61db3d2ea
https://doi.org/10.1073/pnas.2025598118
https://doi.org/10.1073/pnas.2025598118
Autor:
Joachim Hallmayer, Wendy M Froehlich-Santino, Sean Berquist, Jonathan A. Bernstein, Gillian Reierson, Josh Jordan, Carolin Purmann, Alexander E. Urban, Ruth O'Hara
Publikováno v:
Journal of Psychiatric Research. 91:139-144
Purpose To describe the frequency and characteristics of developmental regression in a sample of 50 patients with Phelan McDermid Syndrome (PMS) and investigate the possibility of association between regression, epilepsy, and electroencephalogram (EE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::241aec07363784eb30fa88dc68eb54d9
https://doi.org/10.1016/j.jpsychires.2017.03.010
https://doi.org/10.1016/j.jpsychires.2017.03.010
Autor:
Kasey N. Davis, Jonathan A. Bernstein, Wing Hung Wong, Carolin Purmann, Alexander E. Urban, Shining Ma, Siming Zhang, Joachim Hallmayer, Xianglong Zhang
Heterozygous deletions in the 15q13.3 region are associated with several neuropsychiatric disorders including autism, schizophrenia, and attention deficit hyperactivity disorder. Several genes within the 15q13.3 deletion region may play a role in neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e6c785f83f2cafe4405f9faf2b5f61
https://doi.org/10.1101/772541
https://doi.org/10.1101/772541
Autor:
Sarah Grieder, Reenal Pattni, Yiling Huang, Bruce J. Aronow, Alexander E. Urban, Tom Sudhof, Carolin Purmann, Douglas F. Levinson, Marius Wernig, Xianglong Zhang, ChangHui Pak
Publikováno v:
European Neuropsychopharmacology. 29:S172-S173
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e8ca3f60abd6eda94b80084e3714c99
https://doi.org/10.1016/j.euroneuro.2019.08.112
https://doi.org/10.1016/j.euroneuro.2019.08.112
Autor:
Xiaowei Zhu, Sherman M. Weissman, Carolin Purmann, Michael S. Haney, Thomas J. Ward, Ying Zhang, Jie Yao, Alexander E. Urban, Xianglong Zhang
Publikováno v:
European Neuropsychopharmacology. 29:S854-S855
Background Large Copy Number Variants (CNVs) in the human genome are strongly associated with common neurodevelopmental, neuropsychiatric disorders such as schizophrenia and autism. However, given that these large CNVs each affect many genes directly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8edc9bb9ec383dfe9fae0d7de15e394c
https://doi.org/10.1016/j.euroneuro.2017.08.131
https://doi.org/10.1016/j.euroneuro.2017.08.131
Autor:
Wing Hung Wong, Jonathan A. Bernstein, Alexander E. Urban, Xianglong Zhang, Shining Ma, Carolin Purmann, Kasey N. Davis, Joachim Hallmayer, Siming Zhang
Publikováno v:
European Neuropsychopharmacology. 29:S105
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77d25cf592ce11b14b4c79fd9c1e566b
https://doi.org/10.1016/j.euroneuro.2019.07.222
https://doi.org/10.1016/j.euroneuro.2019.07.222