Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Carolin Herrmann"'
Autor:
Stephen Schüürhuis, Gernot Wassmer, Meinhard Kieser, Friedrich Pahlke, Cornelia Ursula Kunz, Carolin Herrmann
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background In group-sequential designs, it is typically assumed that there is no time gap between patient enrollment and outcome measurement in clinical trials. However, in practice, there is usually a lag between the two time points. This c
Externí odkaz:
https://doaj.org/article/6aef60e81a4b49ffa7cb6ae06dab44fa
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background In clinical trials, the determination of an adequate sample size is a challenging task, mainly due to the uncertainty about the value of the effect size and nuisance parameters. One method to deal with this uncertainty is a sample
Externí odkaz:
https://doaj.org/article/665fb45aa28a4e7f8cf22244c7b7e038
Publikováno v:
Sports Medicine - Open, Vol 10, Iss 1, Pp 1-16 (2024)
Abstract Background Physical inactivity is a growing risk factor worldwide, therefore getting people into sports is necessary. When prescribing physical activity, it is essential to recommend the correct training intensities. Cardiopulmonary exercise
Externí odkaz:
https://doaj.org/article/d0726dabb10346c29ea78ca843c84c50
Autor:
Helena F. Pernice, Adrian L. Knorz, Paul J. Wetzel, Carolin Herrmann, Harisa Muratovic, Finn Rieber, Eleonora Asaad, Gunnar Fiß, Gina Barzen, Elisabeth Blüthner, Fabian Knebel, Sebastian Spethmann, Daniel Messroghli, Bettina Heidecker, Anna Brand, Christoph Wetz, Carsten Tschöpe, Katrin Hahn
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract In contrast to inherited transthyretin amyloidosis (A-ATTRv), neuropathy is not a classic leading symptom of wild type transthyretin amyloidosis (A-ATTRwt). However, neurological symptoms are increasingly relevant in A-ATTRwt as well. To bet
Externí odkaz:
https://doaj.org/article/7b15ceb0ae92486791a996e76dd4bad1
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Background Sample size calculation is a central aspect in planning of clinical trials. The sample size is calculated based on parameter assumptions, like the treatment effect and the endpoint’s variance. A fundamental problem of this appro
Externí odkaz:
https://doaj.org/article/5403381499e9458fa834e01a2148061f
Publikováno v:
BMC Medical Research Methodology, Vol 21, Iss 1, Pp 1-12 (2021)
Abstract Background Statistical model building requires selection of variables for a model depending on the model’s aim. In descriptive and explanatory models, a common recommendation often met in the literature is to include all variables in the m
Externí odkaz:
https://doaj.org/article/8dc6965badb840b79bc26953bc38167d
Publikováno v:
BMC Medical Research Methodology, Vol 20, Iss 1, Pp 1-8 (2020)
Abstract Background In clinical trials with fixed study designs, statistical inference is only made when the trial is completed. In contrast, group sequential designs allow an early stopping of the trial at interim, either for efficacy when the treat
Externí odkaz:
https://doaj.org/article/46b8b46ed1ef4bacb00865c54f32cc79
Publikováno v:
Journal of Statistical Software, Vol 98, Iss 1 (2021)
Even though adaptive two-stage designs with unblinded interim analyses are becoming increasingly popular in clinical trial designs, there is a lack of statistical software to make their application more straightforward. The package adoptr fills this
Externí odkaz:
https://doaj.org/article/dc1e2a152ad144f18206ffbe4fefb41f
Autor:
Tazio Maleitzke, Matthias Pumberger, Undine A Gerlach, Carolin Herrmann, Anna Slagman, Louise S Henriksen, Frederic von Mauchenheim, Nils Hüttermann, Anabel N Santos, Florian N Fleckenstein, Geraldine Rauch, Sven Märdian, Carsten Perka, Ulrich Stöckle, Martin Möckel, Tobias Lindner, Tobias Winkler
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0246956 (2021)
BackgroundThe COVID-19 pandemic led to the implementation of drastic shutdown measures worldwide. While quarantine, self-isolation and shutdown laws helped to effectively contain and control the spread of SARS-CoV-2, the impact of COVID-19 shutdowns
Externí odkaz:
https://doaj.org/article/315d1bf60df14287a0ae3415e635ca65
Publikováno v:
Pharmaceutical Statistics. 21:1121-1137
Adaptive planning of clinical trials allows modifying the entire trial design at any time point mid-course. In this paper, we consider the case when a trial-external update of the planning assumptions during the ongoing trial makes an unforeseen desi