Food Supplements: Definition and Classification

Autor: Carolin Bendadani, Birgit Liebscher, Evelyn Breitweg-Lehmann

Publikováno v: Drug Discovery and Evaluation: Methods in Clinical Pharmacology ISBN: 9783319566375
Drug Discovery and Evaluation: Methods in Clinical Pharmacology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3ff078baadf851f771a1ab9f71aa63
https://doi.org/10.1007/978-3-319-68864-0_67

Metabolism and excretion of 1-hydroxymethylpyrene, the proximate metabolite of the carcinogen 1-methylpyrene, in rats

Autor: Carolin Bendadani, Lisa Steinhauser, Bernhard H. Monien, Klaus Albert, Hansruedi Glatt

Publikováno v: Toxicology.

1-Methylpyrene, an alkylated polycyclic aromatic hydrocarbon and environmental carcinogen, is activated by side-chain hydroxylation to 1-hydroxymethylpyrene (1-HMP) and subsequent sulfo conjugation to the DNA-reactive 1-sulfooxymethylpyrene. In addit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0329de4b99ea4907c8cdeaa1bad2306f
https://pubmed.ncbi.nlm.nih.gov/27501763

The carcinogen 1-methylpyrene forms benzylic DNA adducts in mouse and rat tissues in vivo via a reactive sulphuric acid ester

Autor: Bernhard H. Monien, Carolin Bendadani, Walter Meinl, Gisela Dobbernack, Hansruedi Glatt

Publikováno v: Archives of toxicology. 88(3)

The common polycyclic aromatic hydrocarbon 1-methylpyrene is hepatocarcinogenic in the newborn mouse assay. In vitro studies showed that it is metabolically activated via benzylic hydroxylation and sulphation to a reactive ester, which forms benzylic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8386669ca69ab52846fe73de5975b1b8
https://pubmed.ncbi.nlm.nih.gov/24337722