Associations between sex, body mass index and the individual microglial response in Alzheimer’s disease

Autor: Gloria Biechele, Boris-Stephan Rauchmann, Daniel Janowitz, Katharina Buerger, Nicolai Franzmeier, Endy Weidinger, Selim Guersel, Sebastian Schuster, Anika Finze, Stefanie Harris, Simon Lindner, Nathalie L. Albert, Christian Wetzel, Rainer Rupprecht, Axel Rominger, Carla Palleis, Sabrina Katzdobler, Lena Burow, Carolin Kurz, Mirlind Zaganjori, Lena-Katharina Trappmann, Oliver Goldhardt, Timo Grimmer, Jan Haeckert, Daniel Keeser, Sophia Stoecklein, Estrella Morenas-Rodriguez, Peter Bartenstein, Johannes Levin, Günter U. Höglinger, Mikael Simons, Robert Perneczky, Matthias Brendel

Publikováno v: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-15 (2024)

Abstract Background and objectives 18-kDa translocator protein position-emission-tomography (TSPO-PET) imaging emerged for in vivo assessment of neuroinflammation in Alzheimer’s disease (AD) research. Sex and obesity effects on TSPO-PET binding hav

Externí odkaz: https://doaj.org/article/1204a7a1ca6b4f63bf9f3e18c9bf5978

Tau deposition patterns are associated with functional connectivity in primary tauopathies

Autor: Nicolai Franzmeier, Matthias Brendel, Leonie Beyer, Luna Slemann, Gabor G. Kovacs, Thomas Arzberger, Carolin Kurz, Gesine Respondek, Milica J. Lukic, Davina Biel, Anna Rubinski, Lukas Frontzkowski, Selina Hummel, Andre Müller, Anika Finze, Carla Palleis, Emanuel Joseph, Endy Weidinger, Sabrina Katzdobler, Mengmeng Song, Gloria Biechele, Maike Kern, Maximilian Scheifele, Boris-Stephan Rauchmann, Robert Perneczky, Michael Rullman, Marianne Patt, Andreas Schildan, Henryk Barthel, Osama Sabri, Jost J. Rumpf, Matthias L. Schroeter, Joseph Classen, Victor Villemagne, John Seibyl, Andrew W. Stephens, Edward B. Lee, David G. Coughlin, Armin Giese, Murray Grossman, Corey T. McMillan, Ellen Gelpi, Laura Molina-Porcel, Yaroslau Compta, John C. van Swieten, Laura Donker Laat, Claire Troakes, Safa Al-Sarraj, John L. Robinson, Sharon X. Xie, David J. Irwin, Sigrun Roeber, Jochen Herms, Mikael Simons, Peter Bartenstein, Virginia M. Lee, John Q. Trojanowski, Johannes Levin, Günter Höglinger, Michael Ewers

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

Tau pathology drives neuronal dysfunction in 4- repeat tauopathies. Here, the authors combine tau-PET, resting-state fMRI and histopathology data, to show that brain connectivity is associated with tau deposition patterns in 4-repeat tauopathies.

Externí odkaz: https://doaj.org/article/bd1a4c237aa0450eb6ad79b56669c4c6

A 6-items Questionnaire (6-QMD) captures a Mediterranean like dietary pattern and is associated with memory performance and hippocampal volume in elderly and persons at risk for Alzheimer’s disease

Autor: Boris-Stephan Rauchmann, Patrizia Gross, Ersin Ersoezlue, Michael Wagner, Ballarini Tommaso, Carolin Kurz, Maia Tatò, Julia Utecht, Boris Papazov, Selim Guersel, Marie Totzke, Lena Trappmann, Lena Burow, Gabriele Koller, Sophia Stöcklein, Daniel Keeser, Slawek Altenstein, Claudia Bartels, Katharina Buerger, Peter Dechent, Laura Dobisch, Michael Ewers, Klaus Fliessbach, Silka Dawn Freiesleben, Wenzel Glanz, Doreen Goeerss, Daria Gref, John Dylan Haynes, Daniel Janowitz, Ingo Kilimann, Okka Kimmich, Luca Kleineidam, Christoph Laske, Andrea Lohse, Franziska Maier, Coraline D. Metzger, Matthias H. Munk, Oliver Peters, Lukas Preis, Josef Priller, Sandra Roeske, Nina Roy, Carolin Sanzenbacher, Klaus Scheffler, Anja Schneider, Björn Hendrik Schott, Annika Spottke, Eike Jakob Spruth, Stefan Teipel, Debora Melo van Lent, Jens Wiltfang, Steffen Wolfsgruber, Renat Yakupov, Emrah Düzel, Frank Jessen, Robert Perneczky

Publikováno v: Nutrition and Healthy Aging. :1-14

BACKGROUND: There is evidence that adherence to Mediterranean-like diet reduces cognitive decline and brain atrophy in Alzheimer's disease (AD). However, lengthy dietary assessments, such as food frequency questionnaires (FFQs), discourage more frequ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8f354680492e29893945c8fb4a14119
https://doi.org/10.3233/nha-220190

Subcortical tau‐accumulation predicts neuronal dysfunction in the cortex based on functional connectivity in 4R‐tauopathies

Autor: Sebastian Niclas Roemer, Nicolai Franzmeier, Sabrina Katzdobler, Alexander Nitschmann, Henryk Barthel, Gerard N Bischof, Leonie Beyer, Ken Marek, Mengmeng Song, Olivia Wagemann, Carla Palleis, Anne Nack, Urban Fietzek, Carolin Kurz, Jan Haeckert, Theresa Stapf, Chrsitian Ferschmann, Maximilian Scheifele, Florian Eckenweber, Gloria Biechele, Davina Biel, Anna Dewenter, Anna Steward, Sonja Schoenecker, Dorothee Saur, Matthias L. Schroeter, Jost‐Julian Rumpf, Michael Rullmann, Andreas Schildan, Marianne Patt, Andrew W Stephens, Thilo van Eimeren, Alexander Drzezga, Adrian Danek, Joseph Classen, Katharina Bürger, Daniel Janowitz, Boris‐Stephan Rauchmann, Sophia Stöcklein, Robert Perneczky, Florian Schoeberl, Andreas Zwergal, Peter Bartenstein, Bernd Neumaier, Victor L Villemagne, John Seibyl, Osama Sabri, Michael Ewers, Johannes Levin, Matthias Brendel, Günter Höglinger

Publikováno v: Alzheimer's & Dementia. 18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c788ff5a4a0016f4fcb0c1b1f1f1a2b
https://doi.org/10.1002/alz.067233

Distribution patterns of tau pathology in progressive supranuclear palsy

Autor: Gabor G. Kovacs, Edward B. Lee, Ellen Gelpi, Corey T. McMillan, Claire Troakes, David G. Coughlin, Sharon X. Xie, John Q. Trojanowski, Carolin Kurz, Günter U. Höglinger, Gesine Respondek, Armin Giese, Murray Grossman, David J. Irwin, Yaroslau Compta, Thomas Arzberger, Laura Donker Laat, Virginia M.-Y. Lee, John L. Robinson, Safa Al-Sarraj, Milica Ječmenica Lukić, John C. van Swieten, Sigrun Roeber

Publikováno v: Acta neuropathologica, vol 140, iss 2
Acta Neuropathologica
Acta neuropathologica 140(2), 99-119 (2020). doi:10.1007/s00401-020-02158-2
Kovacs, G G, Lukic, M J, Irwin, D J, Arzberger, T, Respondek, G, Lee, E B, Coughlin, D, Giese, A, Grossman, M, Kurz, C, McMillan, C T, Gelpi, E, Compta, Y, van Swieten, J C, Laat, L D, Troakes, C, Al-Sarraj, S, Robinson, J L, Roeber, S, Xie, S X, Lee, V M Y, Trojanowski, J Q & Höglinger, G U 2020, ' Distribution patterns of tau pathology in progressive supranuclear palsy ', Acta Neuropathologica, vol. 140, no. 2, pp. 99-119 . https://doi.org/10.1007/s00401-020-02158-2
Acta Neuropathologica, 140(2), 99-119. Springer-Verlag

Progressive supranuclear palsy (PSP) is a 4R-tauopathy predominated by subcortical pathology in neurons, astrocytes, and oligodendroglia associated with various clinical phenotypes. In the present international study, we addressed the question of whe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc72025191a7cb50eb9478ae655f1bb
https://doi.org/10.1007/s00401-020-02158-2