Výsledky vyhledávání - "Carolin, Kleider"

Influence of breast cancer risk factors and intramammary biotransformation on estrogen homeostasis in the human breast

Autor: Carolin Kleider, Daniela Pemp, Claudia Wigmann, Katja Schmalbach, Leane Lehmann, Leo N. Geppert, Katja Ickstadt, René Hauptstein, Harald L. Esch

Publikováno v: Archives of Toxicology

Understanding intramammary estrogen homeostasis constitutes the basis of understanding the role of lifestyle factors in breast cancer etiology. Thus, the aim of the present study was to identify variables influencing levels of the estrogens present i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a202199371d147097c755fb5954c307d
http://europepmc.org/articles/PMC7415756

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Validation of a GC- and LC-MS/MS based method for the quantification of 22 estrogens and its application to human plasma

Autor: Carolin, Kleider, Jeniffer, Calderón Giraldo, Daniela, Pemp, Harald L, Esch, Leane, Lehmann

Publikováno v: Steroids. 186:109077

In epidemiological studies, blood levels of 17β-estradiol (E2) are associated with hormone-dependent diseases. The lack of specific methods impedes studies on the role of E2 metabolites and their conjugates in the etiology of hormone-dependent disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a432ea52f09a87eb67f8aa0c3958a125
https://doi.org/10.1016/j.steroids.2022.109077

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Qualitative and quantitative differences in estrogen biotransformation in human breast glandular and adipose tissues: implications for studies using mammary biospecimens

Autor: Peter Eckert, Katja Schmalbach, Daniela Pemp, Harald L. Esch, Iva Neshkova, Rafael G. Jakubietz, Leo N. Geppert, René Hauptstein, Katja Ickstadt, Leane Lehmann, Carolin Kleider, Claudia Köllmann

Publikováno v: Archives of Toxicology. 93:2823-2833

Because of its assumed role in breast cancer etiology, estrogen biotransformation (and interaction of compounds therewith) has been investigated in human biospecimens for decades. However, little attention has been paid to the well-known fact that la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0337ffc3fdcc31701a54476fdac5969d
https://doi.org/10.1007/s00204-019-02564-w

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(R)‐ Tonkafuranone and related compounds: Improved synthesis, stereochemical purity in nature, and bioactivities of the pure enantiomers

Autor: Bruno Rothmund, Gerhard Bringmann, Sandra Gunesch, Michael Decker, Matthias Hoffmann, Carolin Kleider, Jean‐Pierre Mufusama Koy Sita, Leane Lehmann

Publikováno v: Flavour and Fragrance Journal. 34:329-338

Dehydromenthofurolactone (tonkafuranone) and other bicyclic lactones are common flavour compounds and can be found in a variety of plants. Herein, we present an improved synthesis of the natural product and a series of close analogues, in combination

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f471c63c762b7f54f5ff1c618dc2188c
https://doi.org/10.1002/ffj.3513

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Novel insight in estrogen homeostasis and bioactivity in the ACI rat model of estrogen-induced mammary gland carcinogenesis

Autor: Daniela Pemp, Günter Vollmer, Katharina Schlereth, Leane Lehmann, Maarten C. Bosland, Harald L. Esch, Carolin Kleider, Leo N. Geppert, René Hauptstein, Frank Möller, Oliver Zierau

Publikováno v: Archives of toxicology. 93(7)

Despite being widely used to investigate 17β-estradiol (E2)-induced mammary gland (MG) carcinogenesis and prevention thereof, estrogen homeostasis and its significance in the female August Copenhagen Irish (ACI) rat model is unknown. Thus, levels of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::689ccc6bc9e8e4dd98e05f48867a0e5d
https://pubmed.ncbi.nlm.nih.gov/31119341

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Isoflavones

Autor: Anne Scheffler, Leane Lehmann, Harald L. Esch, Carolin Kleider

In Eastern Asia, coronary heart disease as well as breast and prostate cancer are less frequent than in Western countries, which is considered to be due to the Asian diet. Because Asians consume much more soy-based food products, putative beneficial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d09c9cdf2ac74750f8eda695934553f6
https://doi.org/10.1016/b978-0-12-802147-7.00034-6

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