Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Carolien Wansleeben"'
Autor:
Lorena Giuranno, Eloy M. Roig, Carolien Wansleeben, Annette van denBerg, Arjan J. Groot, Ludwig Dubois, Marc Vooijs
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 7, Pp 799-812 (2020)
Abstract Hyperactivity of the NOTCH pathway is associated with tumor growth and radiotherapy resistance in lung cancer, and NOTCH/γ‐secretase inhibitors (GSIs) are a potential therapeutic target. The therapeutic outcome, however, is often restrict
Externí odkaz:
https://doaj.org/article/5940253b822140699faa623d3186f1dc
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e93496 (2014)
We report here senescent changes in the structure and organization of the mucociliary pseudostratified epithelium of the mouse trachea and main stem bronchi. We confirm previous reports of the gradual appearance of age-related, gland-like structures
Externí odkaz:
https://doaj.org/article/32046a7bda5a411b9158b9d63cf3a69c
Autor:
Carolien Wansleeben, Léon van Gurp, Harma Feitsma, Carla Kroon, Ester Rieter, Marlies Verberne, Victor Guryev, Edwin Cuppen, Frits Meijlink
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19357 (2011)
BACKGROUND: Mutagenesis screens in the mouse have been proven useful for the identification of novel gene functions and generation of interesting mutant alleles. Here we describe a phenotype-based screen for recessive mutations affecting embryonic de
Externí odkaz:
https://doaj.org/article/5139dec19ac9416e8d5e82a3792a9c57
Autor:
Ludwig Dubois, Marc Vooijs, Arjan J. Groot, Eloy Moreno Roig, Annette van den Berg, Carolien Wansleeben, Lorena Giuranno
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 7, Pp 799-812 (2020)
Stem Cells Translational Medicine
Stem Cells Translational Medicine, 9(7), 799-812. AlphaMed Press
Stem Cells Translational Medicine
Stem Cells Translational Medicine, 9(7), 799-812. AlphaMed Press
Hyperactivity of the NOTCH pathway is associated with tumor growth and radiotherapy resistance in lung cancer, and NOTCH/γ-secretase inhibitors (GSIs) are a potential therapeutic target. The therapeutic outcome, however, is often restricted by the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e955a3bc700239b827295c3098a23d
https://cris.maastrichtuniversity.nl/en/publications/01922180-0c31-49c0-8551-28b5ef6bbe99
https://cris.maastrichtuniversity.nl/en/publications/01922180-0c31-49c0-8551-28b5ef6bbe99
Autor:
Marc Vooijs, Judith Hounjet, Raffaella Iannone, Arjan J. Groot, Louise Arathoon, Lorena Giuranno, Carolien Wansleeben
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology, 317(3), L414-L423. American Physiological Society
Radiation-induced lung injury to normal airway epithelium is a frequent side-effect and dose-limiting factor in radiotherapy of tumors in the thoracic cavity. NOTCH signaling plays key roles in self-renewal and differentiation of upper airway basal l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60cc94d896e4c635d9e0bd183aaa5e90
https://doi.org/10.1152/ajplung.00197.2019
https://doi.org/10.1152/ajplung.00197.2019
Publikováno v:
Radiotherapy and Oncology. 127:S306-S307
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc636f309f4d2677e92f79bcb3f54c73
https://doi.org/10.1016/s0167-8140(18)30896-x
https://doi.org/10.1016/s0167-8140(18)30896-x
Publikováno v:
Wiley Interdisciplinary Reviews: Developmental Biology. 2:131-148
The lung has vital functions in gas exchange and immune defense. To fulfill these functions the cellular composition and complex three-dimensional organization of the organ must be maintained for a lifetime. Cell turnover in the adult lung is normall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a77c3707a9b46eed5b90a46da99d9f1a
https://doi.org/10.1002/wdev.58
https://doi.org/10.1002/wdev.58
Autor:
Mireille Montcouquiol, Frits Meijlink, Edwin Cuppen, Carla Kroon, Harma Feitsma, Carolien Wansleeben
Publikováno v:
Development, 137(7), 1067-1073. Company of Biologists Ltd
Among the cellular properties that are essential for the organization of tissues during animal development, the importance of cell polarity in the plane of epithelial sheets has become increasingly clear in the past decades. Planar cell polarity (PCP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead677a54a20175de6f8b102fc7419f8
https://hdl.handle.net/20.500.11755/b44c5799-3550-46ec-ac13-c6e9563dbb4f
https://hdl.handle.net/20.500.11755/b44c5799-3550-46ec-ac13-c6e9563dbb4f
Publikováno v:
EMBO reports. 15(8)
Small ubiquitin-like modifier (SUMO1-3) conjugation plays a critical role in embryogenesis. Embryos deficient in the SUMO-conjugating enzyme Ubc9 die at the early postimplantation stage. Sumo1(-/-) mice are viable, as SUMO2/3 can compensate for most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f8e847c19ac00c9841c036ed92066c7
https://pubmed.ncbi.nlm.nih.gov/24891386
https://pubmed.ncbi.nlm.nih.gov/24891386
Publikováno v:
WIREs Developmental Biology. 4:311-312
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86bf6f9abcbd5deb5d644005a59edb16
https://doi.org/10.1002/wdev.184
https://doi.org/10.1002/wdev.184