Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Carolien A M Koeleman"'
Autor:
Alessia Visconti, Niccolò Rossi, Albert Bondt, Agnes Hipgrave Ederveen, Gaurav Thareja, Carolien A. M. Koeleman, Nisha Stephan, Anna Halama, Hannah J. Lomax-Browne, Matthew C. Pickering, Xu-jie Zhou, Manfred Wuhrer, Karsten Suhre, Mario Falchi
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-15 (2024)
Abstract Background Immunoglobulin (Ig) glycosylation modulates the immune response and plays a critical role in ageing and diseases. Studies have mainly focused on IgG glycosylation, and little is known about the genetics and epidemiology of IgA gly
Externí odkaz:
https://doaj.org/article/ecaa1900ce4c4ce1bc7ee82e4afe3d17
Autor:
L Renee Ruhaak, Carolien A M Koeleman, Hae-Won Uh, Jord C Stam, Diana van Heemst, Andrea B Maier, Jeanine J Houwing-Duistermaat, Paul J Hensbergen, P Eline Slagboom, André M Deelder, Manfred Wuhrer
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73082 (2013)
Protein N-glycosylation patterns are known to show vast genetic as well as physiological and pathological variation and represent a large pool of potential biomarkers. Large-scale studies are needed for the identification and validation of biomarkers
Externí odkaz:
https://doaj.org/article/8b0bcfa75e27459b97fd9da91588f83d
Autor:
Kursat O. Yaykasli, Karin A. van Schie, René E. M. Toes, Manfred Wuhrer, Carolien A. M. Koeleman, Galyna Bila, Nazar Negrych, Georg Schett, Jasmin Knopf, Martin Herrmann, Rostyslav Bilyy
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6478 (2024)
Sepsis is a life-threatening condition with a rising disease burden worldwide. It is a multifactorial disease and is defined as a dysregulated host response to infection. Neutrophils have been shown to be involved in the pathogenesis of sepsis by exa
Externí odkaz:
https://doaj.org/article/bbb7bb49faa3474493199f1af55fb5a6
Autor:
L Renee Ruhaak, Hae-Won Uh, Marian Beekman, Carolien A M Koeleman, Cornelis H Hokke, Rudi G J Westendorp, Manfred Wuhrer, Jeanine J Houwing-Duistermaat, P Eline Slagboom, André M Deelder
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12566 (2010)
BackgroundMarkers for longevity that reflect the health condition and predict healthy aging are extremely scarce. Such markers are, however, valuable in aging research. It has been shown previously that the N-glycosylation pattern of human immunoglob
Externí odkaz:
https://doaj.org/article/254679fc5da44461af61d94e662aee7f
Autor:
Thijs L. J. van Osch, Juulke Steuten, Jan Nouta, Carolien A. M. Koeleman, Arthur E. H. Bentlage, Sebastiaan Heidt, Arend Mulder, Jan Voorberg, S. Marieke van Ham, Manfred Wuhrer, Anja ten Brinke, Gestur Vidarsson
Publikováno v:
Platelets, Vol 34, Iss 1 (2023)
Immune-mediated platelet refractoriness (PR) remains a significant problem in the setting of platelet transfusion and is predominantly caused by the presence of alloantibodies directed against class I human leukocyte antigens (HLA). Opsonization of d
Externí odkaz:
https://doaj.org/article/754df94de50f494c88b096ba4996ae54
Autor:
David Falck, Martin Lechmann, Ana Momčilović, Marco Thomann, Carolien A. M. Koeleman, Cordula Jany, Sebastian Malik, Manfred Wuhrer, Dietmar Reusch
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
A relatively low clearance is one of the prominent favorable features of immunoglobulin G1-based therapeutic monoclonal antibodies (mAbs). Various studies have observed differential clearance of mAb glycoforms, including oligomannose glycoforms, whic
Externí odkaz:
https://doaj.org/article/968dcd0ed8d74a8d99c692168604e66f
Autor:
Thijs L.J. van Osch, Janita J. Oosterhoff, Arthur E. H. Bentlage, Jan Nouta, Carolien A. M. Koeleman, Dionne M. Geerdes, Juk Yee Mok, Sebastiaan Heidt, Arend Mulder, Wim J. E. van Esch, Rick Kapur, Leendert Porcelijn, C. Ellen van der Schoot, Masja de Haas, Manfred Wuhrer, Jan Voorberg, Gestur Vidarsson
Publikováno v:
Haematologica, Vol 107, Iss 10 (2022)
Approximately 20% of patients receiving multiple platelet transfusions develop platelet alloantibodies, which can be directed against human leukocyte antigens (HLA) and, to a lesser extent, against human platelet antigens (HPA). These antibodies can
Externí odkaz:
https://doaj.org/article/2ab7eb4a05cb4649a5b5c522cd346344
Autor:
David Falck, Marco Thomann, Martin Lechmann, Carolien A. M. Koeleman, Sebastian Malik, Cordula Jany, Manfred Wuhrer, Dietmar Reusch
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Good pharmacokinetic (PK) behavior is a key prerequisite for sufficient efficacy of therapeutic monoclonal antibodies (mAbs). Fc glycosylation is a critical quality attribute (CQA) of mAbs, due to its impact on stability and effector functions. Howev
Externí odkaz:
https://doaj.org/article/f5a656560dec4220be81529f17f91f15
Autor:
Myrthe E. Sonneveld, Carolien A. M. Koeleman, H. Rosina Plomp, Manfred Wuhrer, C. Ellen van der Schoot, Gestur Vidarsson
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
After albumin, immunoglobulin G (IgG) are the most abundant proteins in human serum, with IgG1 and IgG3 being the most abundant subclasses directed against protein antigens. The quality of the IgG-Fc-glycosylation has important functional consequence
Externí odkaz:
https://doaj.org/article/09b34da814c8445c8aa088a10b8e3e26
Autor:
Gillian Dekkers, Louise Treffers, Rosina Plomp, Arthur E. H. Bentlage, Marcella de Boer, Carolien A. M. Koeleman, Suzanne N. Lissenberg-Thunnissen, Remco Visser, Mieke Brouwer, Juk Yee Mok, Hanke Matlung, Timo K. van den Berg, Wim J. E. van Esch, Taco W. Kuijpers, Diana Wouters, Theo Rispens, Manfred Wuhrer, Gestur Vidarsson
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Glycosylation of the immunoglobulin G (IgG)-Fc tail is required for binding to Fc-gamma receptors (FcγRs) and complement-component C1q. A variety of IgG1-glycoforms is detected in human sera. Several groups have found global or antigen-specific skew
Externí odkaz:
https://doaj.org/article/87f60415914a4cbe869393823da2506a