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Autor:
Matthew Betzenhauser, Paula S. Hochman, Miller Stephan S, Mohammad Zafari, Laura Runkel, Celine Muldowney, Michael Karpusas, Adrian Whitty, Christopher D. Benjamin, Carole deDios
Publikováno v:
Biochemistry. 39(10)
A systematic mutational analysis of human interferon-beta-1a (IFN-beta) was performed to identify regions on the surface of the molecule that are important for receptor binding and for functional activity. The crystal structure of IFN-beta-1a was use