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The effect of long‐term left ventricular assist device support on myocardial sympathetic activity in patients with non‐ischaemic dilated cardiomyopathy

Autor: Robert S. George, Carole Webb, A. Cheetham, Asghar Khaghani, R. T. Smolenski, Emma J. Birks, Magdi H. Yacoub, A. Kelion

Publikováno v: European Journal of Heart Failure. 15:1035-1043

Aims Dilated cardiomyopathy (DCM) patients have abundant levels of norepinephrine secondary to failure of the norepinephrine transporter uptake mechanism. Little is known about the effects of an LV assist device (LVAD) on cardiac sympathetic innervat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05fb1cdaa3cd325e4e130de96b0a1025
https://doi.org/10.1093/eurjhf/hft059

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Metabolic analysis of the response of Pseudomonas putida DOT-T1E strains to toluene using Fourier transform infrared spectroscopy and gas chromatography mass spectrometry

Autor: Drupad K. Trivedi, Yun Xu, Howbeer Muhamadali, Nicholas J. W. Rattray, Carole Webb, David I. Ellis, Najla AlMasoud, Royston Goodacre, Ali Sayqal

Publikováno v: Sayqal, A, Xu, Y, Trivedi, D, Almasoud, N, Ellis, D, Muhamadali, H, Rattray, N, Webb, C & Goodacre, R 2016, ' Metabolic analysis of the response of Pseudomonas putida DOT-T1E strains to toluene using Fourier transform infrared spectroscopy and gas chromatography mass spectrometry ', Metabolomics, vol. 12, no. 112, 14 . https://doi.org/10.1007/s11306-016-1054-1
Metabolomics

Introduction An exceptionally interesting stress response of Pseudomonas putida strains to toxic substances is the induction of efflux pumps that remove toxic chemical substances from the bacterial cell out to the external environment. To exploit the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c4bed6cba933af64ec50cf659bd2e8
https://doi.org/10.1007/s11306-016-1054-1

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Reversal of Severe Heart Failure With a Continuous-Flow Left Ventricular Assist Device and Pharmacological Therapy

Autor: Gilles D. Dreyfus, Toufan Bahrami, Christopher T. Bowles, M. H. Yacoub, Penny Wilton, Carole Webb, Emma J. Birks, Mike Hedger, Robert S. George, Asghar Khaghani, R Bougard, Mohammed Amrani

Publikováno v: Circulation. 123:381-390

Background— We have previously shown that a specific combination of drug therapy and left ventricular assist device unloading results in significant myocardial recovery, sufficient to allow pump removal, in two thirds of patients with dilated cardi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff0fba91814300c60fd0cdd9c4f0d3e
https://doi.org/10.1161/circulationaha.109.933960

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Hemodynamic and Echocardiographic Responses to Acute Interruption of Left Ventricular Assist Device Support: Relevance to Assessment of Myocardial Recovery

Autor: Patrick Tansley, Emma J. Birks, Gilles D. Dreyfus, Robert S. George, J Hardy, Magdi H. Yacoub, Carole Webb, Giordano Tasca, Christopher T. Bowles, Asghar Khaghani

Publikováno v: The Journal of Heart and Lung Transplantation. 26:967-973

Assessment of myocardial recovery during left ventricular assist device (LVAD) support is difficult to perform both safely and effectively. We developed a test involving short-term interruption of LVAD support with measurements of several hemodynamic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fba92951f572eeef846cb08b3664705
https://doi.org/10.1016/j.healun.2007.07.021

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The PULSE Initiative

Autor: Robert Wise, Karl Kern, James Carrico, Herbert Wiedemann, Myron L. Weisfeldt, Thomas Budinger, Lance B. Becker, Graham Nichol, Carole Webb, Richard J. Traystman, Ishaiahu Shechter, George Sopko, Max H. Weil

Publikováno v: Circulation. 105:2562-2570

The Post-resuscitative and initial Utility in Life Saving Efforts (PULSE) Conference represented an initiative by leaders of the international scientific community who sought opportunities for major improvements in clinical outcomes after cardiopulmo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90f44ee2cb5e7e560ecd8dc799a3a74b
https://doi.org/10.1161/01.cir.0000017142.39991.c3

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Echocardiographic assessment of flow across continuous-flow ventricular assist devices at low speeds

Autor: Nikant K. Sabharwal, Michael Hedger, Asghar Khaghani, Christopher Bowles, Emma J. Birks, Robert S. George, Carole Webb, Magdi H. Yacoub

Publikováno v: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 29(11)

Testing of native myocardial function in patients with continuous-flow pumps is challenging as reduction/cessation of the pump could result in regurgitation, although the amount and significance of this regurgitation remains unknown. The aim of this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e29d20d4c5a0ee81cb9cfa7e91ef607
https://pubmed.ncbi.nlm.nih.gov/20688540

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Abstract 5854: Serial Assessment of Pulsatile and Non-Pulsatile Left Ventricular Assist Devices on Left Ventricular Unloading

Autor: Robert S George, Magdi H Yacoub, Carole Webb, Christopher Bowles, Robert Dean, Mike Hedger, Giles Dreyfus, Asghar Khaghani, Emma J Birks

Publikováno v: Circulation. 118

Pulsatile and continuous flow left ventricular assist device (LVAD)s combined with pharmacological agents have been used to bridge patients with end-stage dilated cardiomyopathy (DCM) to recovery. The aim of this study was to compare the effects of p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0300455d6bdbf4811c1def56b95df5d0
https://doi.org/10.1161/circ.118.suppl_18.s_1016-a

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