Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Carole Sourbier"'
Autor:
Martin Lang, Laura S. Schmidt, Kelli M. Wilson, Christopher J. Ricketts, Carole Sourbier, Cathy D. Vocke, Darmood Wei, Daniel R. Crooks, Youfeng Yang, Benjamin K. Gibbs, Xiaohu Zhang, Carleen Klumpp-Thomas, Lu Chen, Rajarshi Guha, Marc Ferrer, Crystal McKnight, Zina Itkin, Darawalee Wangsa, Danny Wangsa, Amy James, Simone Difilippantonio, Baktir Karim, Francisco Morís, Thomas Ried, Maria J. Merino, Ramaprasad Srinivasan, Craig J. Thomas, W. Marston Linehan
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-14 (2023)
Abstract Background MiT-Renal Cell Carcinoma (RCC) is characterized by genomic translocations involving microphthalmia-associated transcription factor (MiT) family members TFE3, TFEB, or MITF. MiT-RCC represents a specific subtype of sporadic RCC tha
Externí odkaz:
https://doaj.org/article/6b0458681f774fc788c19d8f3ed9c6d2
Autor:
Guangyuan Li, Susmita Ghosh, JuMe Park, Hyunsu Shin, Mamatha Garige, Gregory Reaman, Carole Sourbier
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Immune checkpoint inhibitors (ICIs) have changed the therapeutic landscape for cancer patients, but diabetes, a rare, severe immune-related endocrinopathy, is linked to ICI therapy. It is unclear whether glycosylation of ICIs may play a role in the d
Externí odkaz:
https://doaj.org/article/20ca78b0cd0d44e6945432b85dabbcf8
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Externí odkaz:
https://doaj.org/article/dd63d429121944db8cf6900eb7d20452
Autor:
Mamatha Garige, Sarah Poncet, Alexis Norris, Chao-Kai Chou, Wells W. Wu, Rong-Fong Shen, Jacob W. Greenberg, Louis Spencer Krane, Carole Sourbier
Publikováno v:
Life, Vol 13, Iss 5, p 1196 (2023)
Opioids are commonly prescribed for extended periods of time to patients with advanced clear cell renal cell carcinoma to assist with pain management. Because extended opioid exposure has been shown to affect the vasculature and to be immunosuppressi
Externí odkaz:
https://doaj.org/article/f08346a3867445ad98755d9aec163075
Publikováno v:
Methods and Protocols, Vol 6, Iss 2, p 33 (2023)
Insulin is a hormone produced by β-cells of the pancreas and controls the amount of sugar in the blood. Since its discovery over 100 years ago, insulin has been used as a life-saving treatment for people with diabetes. Historically, the biological a
Externí odkaz:
https://doaj.org/article/3f7e9197a03149009a37e674ba41913c
Autor:
Mamatha Garige, Susmita Ghosh, Alexis Norris, Guangyuan Li, Sarah Poncet, Chao-Kai Chou, Wells W. Wu, Rong-Fong Shen, Carole Sourbier
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The immune checkpoint programmed death-ligand 1 (PD-L1) is expressed on the cell surface of tumor cells and is key for maintaining an immunosuppressive microenvironment through its interaction with the programmed death 1 (PD-1). Clear cell renal cell
Externí odkaz:
https://doaj.org/article/f478bab173b34a1bb08f1f2d8c0707c4
Autor:
Ha-Na Lee, Mohanraj Manangeeswaran, Aaron P. Lewkowicz, Kaliroi Engel, Monica Chowdhury, Mamatha Garige, Michael A. Eckhaus, Carole Sourbier, Derek D.C. Ireland, Daniela Verthelyi
Publikováno v:
JCI Insight, Vol 7, Iss 3 (2022)
Immune cells express an array of inhibitory checkpoint receptors that are upregulated upon activation and limit tissue damage associated with excessive response to pathogens or allergens. Mouse leukocyte immunoglobulin like receptor B4 (LILRB4), also
Externí odkaz:
https://doaj.org/article/ed586e07f74c46d2b1ffedf5bb2ac318
Autor:
Eric C. Kauffman, Martin Lang, Soroush Rais-Bahrami, Gopal N. Gupta, Darmood Wei, Youfeng Yang, Carole Sourbier, Ramaprasad Srinivasan
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-12 (2019)
Abstract Background Renal cell carcinomas (RCC) harboring a TFE3 gene fusion (TfRCC) represent an aggressive subset of kidney tumors. Key signaling pathways of TfRCC are unknown and preclinical in vivo data are lacking. We investigated Akt/mTOR pathw
Externí odkaz:
https://doaj.org/article/696cb64c4fe04f6c9333b63f75d6702e
Autor:
Carole Sourbier
Publikováno v:
EBioMedicine, Vol 25, Iss C, Pp 7-8 (2017)
Externí odkaz:
https://doaj.org/article/e60cee39d1964874b40446cac6dc97a0
Autor:
Alessio Giubellino, Carole Sourbier, Min-Jung Lee, Brad Scroggins, Petra Bullova, Michael Landau, Weiwen Ying, Len Neckers, Jane B Trepel, Karel Pacak
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56083 (2013)
Metastatic pheochromocytoma represents one of the major clinical challenges in the field of neuroendocrine oncology. Recent molecular characterization of pheochromocytoma suggests new treatment options with targeted therapies. In this study we invest
Externí odkaz:
https://doaj.org/article/c48752536b4543e1a016f846ad0fb09b