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pro vyhledávání: '"Carole Sackur"'
Autor:
Valerie Brault, Sonia Bernetiere, José Camara, Pascale Plas, Pierre Roubert, Lydie Poitout, Carole Sackur
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4464-4470
A novel series of benzimidazoles was identified and optimized, leading to the discovery of potent and selective antagonists of the human melanocortin-4 receptor. In addition, compound 5i was shown to cross the blood-brain barrier after intravenous do