Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Carole S. Frye"'
Autor:
Yoshihiro Higuichi, Carole S. Frye, Arthur M. Feldman, Charles F. McTiernan, Toru Kubota, Toshiaki Kadokami
Publikováno v:
Journal of Interferon & Cytokine Research. 25:254-260
A transgenic mouse model of congestive heart failure (CHF) consequent to cardiac-specific overexpression of tumor necrosis factor-alpha (TNF-alpha) (TNF1.6) displays marked sex-related phenotypic differences. To clarify the potential contributions of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763a911bac6e8c0c186e0d4e98e57a25
https://doi.org/10.1089/jir.2005.25.254
https://doi.org/10.1089/jir.2005.25.254
Autor:
Carole S. Frye, Charles F. McTiernan, Steven S. Brooks, Bonnie Lemster, Alain Combes, Arthur M. Feldman, Simon C. Watkins
Publikováno v:
Pfl�gers Archiv European Journal of Physiology. 445:246-256
While proinflammatory cytokines can depress cardiac contractility, the mechanism by which this occurs remains unclear. To clarify the cellular effects of interleukin (IL)-1beta, we assessed contractility, calcium homeostasis, and gene expression in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ceca2a7bf5408ab74aa8fce3edb9830
https://doi.org/10.1007/s00424-002-0921-y
https://doi.org/10.1007/s00424-002-0921-y
Autor:
George S. Bounoutas, Toru Kubota, Charles F. McTiernan, Masayuki Miyagishima, Arthur M. Feldman, Sean Alber, Toshiaki Kadokami, Simon C. Watkins, Carole S. Frye
Publikováno v:
Journal of Molecular and Cellular Cardiology. 33:1331-1344
We have previously reported that mice with cardiac-specific overexpression of tumor necrosis factor (TNF)- alpha develop myocardial inflammation, cardiac hypertrophy, and dilated cardiomyopathy. TNF- alpha is reported to induce apoptosis in cultured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd16d7bf5e171a727691f3d48419e91
https://doi.org/10.1006/jmcc.2001.1393
https://doi.org/10.1006/jmcc.2001.1393
Publikováno v:
Journal of Biological Chemistry. 276:20679-20687
A complex family of 4.1R isoforms has been identified in non-erythroid tissues. In this study we characterized the exonic composition of brain 4.1R-10-kDa or spectrin/actin binding (SAB) domain and identified the minimal sequences required to stimula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f524c7ab4dfdc0ceefdb927d258214d1
https://doi.org/10.1074/jbc.m010581200
https://doi.org/10.1074/jbc.m010581200
Publikováno v:
Journal of Clinical Investigation. 106:589-597
Epidemiological evidence suggests that the prognosis of heart failure in women is better than in men. In our murine model of dilated cardiomyopathy arising from cardiac-specific overexpression of TNF-alpha, the 6-month survival rate was significantly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd314a02328885e9cd0d0092672c348
https://doi.org/10.1172/jci9307
https://doi.org/10.1172/jci9307
Publikováno v:
Journal of Cardiac Failure. 3:117-124
Background: Tumor necrosis factor (TNF)-alpha, a proinflammatory cytokine with negative inotropic effects, can be detected in myocardium with end-stage heart failure, after endotoxin administration, and during transplant rejection. Various studies su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45f535b212d4b13a27fc5efd5e0aeda
https://doi.org/10.1016/s1071-9164(97)90045-2
https://doi.org/10.1016/s1071-9164(97)90045-2
Publikováno v:
Journal of cardiac failure. 8(5)
Background: Cytochrome P450 (CYP) enzymes are important mediators of drug metabolism, and activity of these enzymes is a major determinant of the duration and intensity of drug effect. Circulating plasma concentrations of pro-inflammatory cytokines (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546e3a6b2676a28ed9c21a5dfa7e6b57
https://pubmed.ncbi.nlm.nih.gov/12411982
https://pubmed.ncbi.nlm.nih.gov/12411982
Autor:
Toshiaki Kadokami, Carole S. Frye, Charles F. McTiernan, Arthur M. Feldman, Carrie Wagner, Bonnie Lemster
Publikováno v:
Circulation. 104(10)
Background — Tumor necrosis factor (TNF)-α has been implicated in the pathophysiology of congestive heart failure. A strain of transgenic mice (TNF1.6) with cardiac-specific overexpression of TNF-α develop congestive heart failure. Methods and Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50772d4ebf907e84d6faf00383fbead0
https://pubmed.ncbi.nlm.nih.gov/11535561
https://pubmed.ncbi.nlm.nih.gov/11535561
Autor:
Arthur M. Feldman, Paul D. Robbins, Carole S. Frye, Simon C. Watkins, Toshiaki Kadokami, Charles F. McTiernan, Toru Kubota, George S. Bounoutas
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 280(5)
Tumor necrosis factor (TNF)-α plays a key role in the pathogenesis of septic shock syndrome, and myocardial TNF-α expression may contribute to this pathophysiology. We examined the myocardial expression of TNF-α-related cytokines and chemokines in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::077b68b51d398dc1b0510a692e248972
https://pubmed.ncbi.nlm.nih.gov/11299232
https://pubmed.ncbi.nlm.nih.gov/11299232
Publikováno v:
Journal of molecular and cellular cardiology. 31(12)
Phospholamban is a major regulator of cardiac diastole, with alterations in expression associated with modified cardiac relaxation. To study transcriptional regulation of phospholamban expression, we made reporter constructs that expressed luciferase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d303f85a32447e5f669e86003d6a3e7b
https://pubmed.ncbi.nlm.nih.gov/10640442
https://pubmed.ncbi.nlm.nih.gov/10640442